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The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor.
Bone 2006; 39(6):1343-51BONE

Abstract

INTRODUCTION

Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD.

METHODS

We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined.

RESULTS

Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p < 0.004). There was furthermore a trend, in the lumbar spine, of less reduction in BMD with increasing vitamin D intake (p = 0.07) but not at the other sites. Calcium intake conferred no association with BMD.

CONCLUSIONS

Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction.

Authors+Show Affiliations

Department of Surgical Sciences, Section of Orthopaedics, University Hospital, S-751 85 Uppsala, Sweden. Karl.Michaelsson@surgsci.uu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16860619

Citation

Michaëlsson, Karl, et al. "The Positive Effect of Dietary Vitamin D Intake On Bone Mineral Density in Men Is Modulated By the Polyadenosine Repeat Polymorphism of the Vitamin D Receptor." Bone, vol. 39, no. 6, 2006, pp. 1343-51.
Michaëlsson K, Wolk A, Jacobsson A, et al. The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor. Bone. 2006;39(6):1343-51.
Michaëlsson, K., Wolk, A., Jacobsson, A., Kindmark, A., Grundberg, E., Stiger, F., ... Melhus, H. (2006). The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor. Bone, 39(6), pp. 1343-51.
Michaëlsson K, et al. The Positive Effect of Dietary Vitamin D Intake On Bone Mineral Density in Men Is Modulated By the Polyadenosine Repeat Polymorphism of the Vitamin D Receptor. Bone. 2006;39(6):1343-51. PubMed PMID: 16860619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor. AU - Michaëlsson,Karl, AU - Wolk,Alicja, AU - Jacobsson,Annica, AU - Kindmark,Andreas, AU - Grundberg,Elin, AU - Stiger,Fredrik, AU - Mallmin,Hans, AU - Ljunghall,Sverker, AU - Melhus,Håkan, Y1 - 2006/07/24/ PY - 2006/01/20/received PY - 2006/04/10/revised PY - 2006/06/08/accepted PY - 2006/7/25/pubmed PY - 2007/2/21/medline PY - 2006/7/25/entrez SP - 1343 EP - 51 JF - Bone JO - Bone VL - 39 IS - 6 N2 - INTRODUCTION: Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. METHODS: We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined. RESULTS: Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p < 0.004). There was furthermore a trend, in the lumbar spine, of less reduction in BMD with increasing vitamin D intake (p = 0.07) but not at the other sites. Calcium intake conferred no association with BMD. CONCLUSIONS: Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/16860619/The_positive_effect_of_dietary_vitamin_D_intake_on_bone_mineral_density_in_men_is_modulated_by_the_polyadenosine_repeat_polymorphism_of_the_vitamin_D_receptor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(06)00558-8 DB - PRIME DP - Unbound Medicine ER -