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Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Bone Marrow Transplant. 2006 Sep; 38(5):351-7.BM

Abstract

Chronic graft-versus-host disease (cGVHD) is the most common late complication of allogeneic hematopoietic cell transplantation (HCT) causing significant morbidity and mortality. The kidneys are not considered a target organ for cGVHD in humans, although animal models show renal damage. Renal involvement in patients with cGVHD, presenting as nephrotic syndrome (NS), has rarely been reported in patients who received allogeneic transplantation. Herein we describe, by far, the largest series of nine patients with NS associated with cGVHD, including two patients who received a reduced-intensity regimen. Pathological features of membranous nephropathy were the most common finding on renal biopsy. The clinical course of the NS was temporally associated with the classical features of cGVHD in all but one of the nine cases. The clinicopathologic features of NS in our series as well as reports in the literature demonstrate an immunopathologic process typical of antibody-mediated damage consistent with cGVHD. Treatment directed against antibody-mediated damage, such as anti-B-cell antibody may play an important role in ameliorating NS associated with cGVHD.

Authors+Show Affiliations

Blood and Marrow Transplantation Program, Division of Hematology-Oncology, Department of Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA. reddypr@umich.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16862167

Citation

Reddy, P, et al. "Nephrotic Syndrome Associated With Chronic Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation." Bone Marrow Transplantation, vol. 38, no. 5, 2006, pp. 351-7.
Reddy P, Johnson K, Uberti JP, et al. Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2006;38(5):351-7.
Reddy, P., Johnson, K., Uberti, J. P., Reynolds, C., Silver, S., Ayash, L., Braun, T. M., & Ratanatharathorn, V. (2006). Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation, 38(5), 351-7.
Reddy P, et al. Nephrotic Syndrome Associated With Chronic Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation. Bone Marrow Transplant. 2006;38(5):351-7. PubMed PMID: 16862167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. AU - Reddy,P, AU - Johnson,K, AU - Uberti,J P, AU - Reynolds,C, AU - Silver,S, AU - Ayash,L, AU - Braun,T M, AU - Ratanatharathorn,V, Y1 - 2006/07/24/ PY - 2006/7/25/pubmed PY - 2006/9/26/medline PY - 2006/7/25/entrez SP - 351 EP - 7 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 38 IS - 5 N2 - Chronic graft-versus-host disease (cGVHD) is the most common late complication of allogeneic hematopoietic cell transplantation (HCT) causing significant morbidity and mortality. The kidneys are not considered a target organ for cGVHD in humans, although animal models show renal damage. Renal involvement in patients with cGVHD, presenting as nephrotic syndrome (NS), has rarely been reported in patients who received allogeneic transplantation. Herein we describe, by far, the largest series of nine patients with NS associated with cGVHD, including two patients who received a reduced-intensity regimen. Pathological features of membranous nephropathy were the most common finding on renal biopsy. The clinical course of the NS was temporally associated with the classical features of cGVHD in all but one of the nine cases. The clinicopathologic features of NS in our series as well as reports in the literature demonstrate an immunopathologic process typical of antibody-mediated damage consistent with cGVHD. Treatment directed against antibody-mediated damage, such as anti-B-cell antibody may play an important role in ameliorating NS associated with cGVHD. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/16862167/Nephrotic_syndrome_associated_with_chronic_graft_versus_host_disease_after_allogeneic_hematopoietic_stem_cell_transplantation_ L2 - https://doi.org/10.1038/sj.bmt.1705446 DB - PRIME DP - Unbound Medicine ER -