Tags

Type your tag names separated by a space and hit enter

Increasing deaths from opioid analgesics in the United States.
Pharmacoepidemiol Drug Saf. 2006 Sep; 15(9):618-27.PD

Abstract

PURPOSE

Since 1990, numerous jurisdictions in the United States (US) have reported increases in drug poisoning mortality. During the same time period, the use of opioid analgesics has increased markedly as part of more aggressive pain management. This study documented a dramatic increase in poisoning mortality rates and compared it to sales of opioid analgesics nationwide.

METHODS

Trend analysis of drug poisoning deaths using underlying cause of death and multiple cause of death mortality data from the Centers for Disease Control and Prevention and opioid analgesic sales data from the US Drug Enforcement Administration.

RESULTS

Unintentional drug poisoning mortality rates increased on average 5.3% per year from 1979 to 1990 and 18.1% per year from 1990 to 2002. The rapid increase during the 1990s reflects the rising number of deaths attributed to narcotics and unspecified drugs. Between 1999 and 2002, the number of opioid analgesic poisonings on death certificates increased 91.2%, while heroin and cocaine poisonings increased 12.4% and 22.8%, respectively. By 2002, opioid analgesic poisoning was listed in 5528 deaths-more than either heroin or cocaine. The increase in deaths generally matched the increase in sales for each type of opioid. The increase in deaths involving methadone tracked the increase in methadone used as an analgesic rather than methadone used in narcotics treatment programs.

CONCLUSIONS

A national epidemic of drug poisoning deaths began in the 1990s. Prescriptions for opioid analgesics also increased in this time frame and may have inadvertently contributed to the increases in drug poisoning deaths.

Authors+Show Affiliations

Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. lbp4@cdc.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16862602

Citation

Paulozzi, Leonard J., et al. "Increasing Deaths From Opioid Analgesics in the United States." Pharmacoepidemiology and Drug Safety, vol. 15, no. 9, 2006, pp. 618-27.
Paulozzi LJ, Budnitz DS, Xi Y. Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006;15(9):618-27.
Paulozzi, L. J., Budnitz, D. S., & Xi, Y. (2006). Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiology and Drug Safety, 15(9), 618-27.
Paulozzi LJ, Budnitz DS, Xi Y. Increasing Deaths From Opioid Analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006;15(9):618-27. PubMed PMID: 16862602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing deaths from opioid analgesics in the United States. AU - Paulozzi,Leonard J, AU - Budnitz,Daniel S, AU - Xi,Yongli, PY - 2006/7/25/pubmed PY - 2006/12/19/medline PY - 2006/7/25/entrez SP - 618 EP - 27 JF - Pharmacoepidemiology and drug safety JO - Pharmacoepidemiol Drug Saf VL - 15 IS - 9 N2 - PURPOSE: Since 1990, numerous jurisdictions in the United States (US) have reported increases in drug poisoning mortality. During the same time period, the use of opioid analgesics has increased markedly as part of more aggressive pain management. This study documented a dramatic increase in poisoning mortality rates and compared it to sales of opioid analgesics nationwide. METHODS: Trend analysis of drug poisoning deaths using underlying cause of death and multiple cause of death mortality data from the Centers for Disease Control and Prevention and opioid analgesic sales data from the US Drug Enforcement Administration. RESULTS: Unintentional drug poisoning mortality rates increased on average 5.3% per year from 1979 to 1990 and 18.1% per year from 1990 to 2002. The rapid increase during the 1990s reflects the rising number of deaths attributed to narcotics and unspecified drugs. Between 1999 and 2002, the number of opioid analgesic poisonings on death certificates increased 91.2%, while heroin and cocaine poisonings increased 12.4% and 22.8%, respectively. By 2002, opioid analgesic poisoning was listed in 5528 deaths-more than either heroin or cocaine. The increase in deaths generally matched the increase in sales for each type of opioid. The increase in deaths involving methadone tracked the increase in methadone used as an analgesic rather than methadone used in narcotics treatment programs. CONCLUSIONS: A national epidemic of drug poisoning deaths began in the 1990s. Prescriptions for opioid analgesics also increased in this time frame and may have inadvertently contributed to the increases in drug poisoning deaths. SN - 1053-8569 UR - https://www.unboundmedicine.com/medline/citation/16862602/Increasing_deaths_from_opioid_analgesics_in_the_United_States_ L2 - https://doi.org/10.1002/pds.1276 DB - PRIME DP - Unbound Medicine ER -