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Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis.
Int J Dermatol. 2006 Jul; 45(7):819-21.IJ

Abstract

INTRODUCTION

Cutaneous leishmaniasis is a common parasitic disease in Iran, especially in Isfahan. First line treatment for this disease is antimonial compounds; however, owing to the intermittent failure of this treatment and its significant side-effects alternative therapeutic measures have been advocated.

OBJECTIVE

Evaluating the efficacy of pentoxifylline plus glucantime in the treatment of cutaneous leishmaniasis.

METHODS

This double-blind, randomized, controlled clinical trial with simple sampling was performed on 64 patients with cutaneous leishmaniasis referred to the Skin Diseases & Leishmaniasis Research Center from an endemic foci of L. major in Isfahan. The patients randomly were divided into two groups. One group was treated with systemic Glucantime (20 mg pentavalent antimony/kg/day) combined with pentoxifylline (400 mg three times daily) and the other group were treated with Glucantime (20 mg pentavalent antimony/kg/day) plus placebo (three tablets daily) for 20 days. Follow up lasted 3 months. Response to treatment was grouped as complete improvement (lesions had been flattened, no induration, and epidermal creases had appeared), partial improvement (reduction in lesion size, but without the appearance of epidermal creases) and poor response (no reduction in lesion size).

RESULTS

Of 64 participants, 32 patients in the trial group and 31 patients in the control group were followed for 3 months. One patient in group B discontinued withdrew. After this time, complete improvement, partial improvement and poor response to treatment were 81.3%, 12.5% and 6.2% in the trial group and 51.6%, 29% and 19.4% in the control group, respectively. We also observed no adverse effect resulting from pentoxifylline.

DISCUSSION

The result obtained by two therapeutic methods indicates that combined therapy with Glucantime and pentoxifylline is more effective than Glucantime alone (P < 0.05).

Authors+Show Affiliations

Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences and Health Services, and Dermatology Tehran University, Skin Disease and Leishmaniasis Research Center, Isfahan, Iran. Sadeghian@sdlrc.mui.ac.irNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16863518

Citation

Sadeghian, G, and M A. Nilforoushzadeh. "Effect of Combination Therapy With Systemic Glucantime and Pentoxifylline in the Treatment of Cutaneous Leishmaniasis." International Journal of Dermatology, vol. 45, no. 7, 2006, pp. 819-21.
Sadeghian G, Nilforoushzadeh MA. Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis. Int J Dermatol. 2006;45(7):819-21.
Sadeghian, G., & Nilforoushzadeh, M. A. (2006). Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis. International Journal of Dermatology, 45(7), 819-21.
Sadeghian G, Nilforoushzadeh MA. Effect of Combination Therapy With Systemic Glucantime and Pentoxifylline in the Treatment of Cutaneous Leishmaniasis. Int J Dermatol. 2006;45(7):819-21. PubMed PMID: 16863518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis. AU - Sadeghian,G, AU - Nilforoushzadeh,M A, PY - 2006/7/26/pubmed PY - 2006/11/11/medline PY - 2006/7/26/entrez SP - 819 EP - 21 JF - International journal of dermatology JO - Int J Dermatol VL - 45 IS - 7 N2 - INTRODUCTION: Cutaneous leishmaniasis is a common parasitic disease in Iran, especially in Isfahan. First line treatment for this disease is antimonial compounds; however, owing to the intermittent failure of this treatment and its significant side-effects alternative therapeutic measures have been advocated. OBJECTIVE: Evaluating the efficacy of pentoxifylline plus glucantime in the treatment of cutaneous leishmaniasis. METHODS: This double-blind, randomized, controlled clinical trial with simple sampling was performed on 64 patients with cutaneous leishmaniasis referred to the Skin Diseases & Leishmaniasis Research Center from an endemic foci of L. major in Isfahan. The patients randomly were divided into two groups. One group was treated with systemic Glucantime (20 mg pentavalent antimony/kg/day) combined with pentoxifylline (400 mg three times daily) and the other group were treated with Glucantime (20 mg pentavalent antimony/kg/day) plus placebo (three tablets daily) for 20 days. Follow up lasted 3 months. Response to treatment was grouped as complete improvement (lesions had been flattened, no induration, and epidermal creases had appeared), partial improvement (reduction in lesion size, but without the appearance of epidermal creases) and poor response (no reduction in lesion size). RESULTS: Of 64 participants, 32 patients in the trial group and 31 patients in the control group were followed for 3 months. One patient in group B discontinued withdrew. After this time, complete improvement, partial improvement and poor response to treatment were 81.3%, 12.5% and 6.2% in the trial group and 51.6%, 29% and 19.4% in the control group, respectively. We also observed no adverse effect resulting from pentoxifylline. DISCUSSION: The result obtained by two therapeutic methods indicates that combined therapy with Glucantime and pentoxifylline is more effective than Glucantime alone (P < 0.05). SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/16863518/Effect_of_combination_therapy_with_systemic_glucantime_and_pentoxifylline_in_the_treatment_of_cutaneous_leishmaniasis_ DB - PRIME DP - Unbound Medicine ER -