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Comparison of drug eluting stents with bare metal stents in daily practice for bifurcation lesions in Chinese patients.
Chin Med J (Engl). 2006 Jul 20; 119(14):1157-64.CM

Abstract

BACKGROUND

Recently, numerous randomized and controlled trials have demonstrated great advantages of drug eluting stents (DES) with respect to significant reduction of restenosis and recurrence of symptoms and improvement of clinical outcomes after percutaneous coronary intervention (PCI). Little is known about the comparative effects between DES and bare metal stents (BMS) for bifurcation angioplasty in the Chinese population. We compared the inpatient and 7-month follow-up outcomes between DES and BMS for the treatment of bifurcation lesions.

METHODS

From April 2004 to October 2005, 291 Chinese patients [85.9% male, mean age (57.8 +/- 10.4) years] underwent DES (387 lesions) and/or BMS (297 lesions) implantation for bifurcation lesions. Clinical and angiographic follow-up was performed at 7 months.

RESULTS

Compared with BMS group, patients in DES group had significantly lower rates of restenosis at main branch (9.5% vs 28.7%, P < 0.001) or side branch (14.5% vs 37.0%, P < 0.001) and major adverse cardiac events (MACE) (14.0% vs 26.3%, P = 0.000). The occurrence rate of late in-stent thrombosis did not differ between the two groups in both main (0.8% vs 0, P = 0.224) and side branches (1.4% vs 0, P = 0.198). Target lesion revascularization (TLR) was less frequent in DES group for main branch (8.3% vs 21.3%, P < 0.001) and for side branch (7.6% vs 23.5%, P < 0.001). Multivariate regression analysis revealed that total stent length (OR = 1.029, P = 0.01), postprocedural in-stent minimum lumen diameter (OR = 0.476, P = 0.03) and stent type (OR = 3.988, P = 0.0001) were independent predictors of TLR for main branch. Prior history of coronary intervention (OR = 2.424, P = 0.041), angulated lesion (OR = 2.337, P = 0.033), postdilation (OR = 0.267, P = 0.035) and stent type (DES vs BMS, OR = 5.459, P = 0.000) were independent predictors of TLR for side branch.

CONCLUSION

The implantation of DES may be associated with greater reduction of restenosis and TLR than BMS in bifurcations angioplasty.

Authors+Show Affiliations

Department of Cardiology, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16863606

Citation

Kang, Sheng, et al. "Comparison of Drug Eluting Stents With Bare Metal Stents in Daily Practice for Bifurcation Lesions in Chinese Patients." Chinese Medical Journal, vol. 119, no. 14, 2006, pp. 1157-64.
Kang S, Yang YJ, Xu B, et al. Comparison of drug eluting stents with bare metal stents in daily practice for bifurcation lesions in Chinese patients. Chin Med J. 2006;119(14):1157-64.
Kang, S., Yang, Y. J., Xu, B., Chen, J. L., Qiao, S. B., Yao, M., Chen, J., Wu, Y. J., Liu, H. B., Dai, J., Yuan, J. Q., Li, J. J., & Gao, R. L. (2006). Comparison of drug eluting stents with bare metal stents in daily practice for bifurcation lesions in Chinese patients. Chinese Medical Journal, 119(14), 1157-64.
Kang S, et al. Comparison of Drug Eluting Stents With Bare Metal Stents in Daily Practice for Bifurcation Lesions in Chinese Patients. Chin Med J. 2006 Jul 20;119(14):1157-64. PubMed PMID: 16863606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of drug eluting stents with bare metal stents in daily practice for bifurcation lesions in Chinese patients. AU - Kang,Sheng, AU - Yang,Yue-jin, AU - Xu,Bo, AU - Chen,Ji-lin, AU - Qiao,Shu-bin, AU - Yao,Min, AU - Chen,Jue, AU - Wu,Yong-jian, AU - Liu,Hai-bo, AU - Dai,Jun, AU - Yuan,Jin-qing, AU - Li,Jian-jun, AU - Gao,Run-lin, PY - 2006/7/26/pubmed PY - 2006/8/24/medline PY - 2006/7/26/entrez SP - 1157 EP - 64 JF - Chinese medical journal JO - Chin. Med. J. VL - 119 IS - 14 N2 - BACKGROUND: Recently, numerous randomized and controlled trials have demonstrated great advantages of drug eluting stents (DES) with respect to significant reduction of restenosis and recurrence of symptoms and improvement of clinical outcomes after percutaneous coronary intervention (PCI). Little is known about the comparative effects between DES and bare metal stents (BMS) for bifurcation angioplasty in the Chinese population. We compared the inpatient and 7-month follow-up outcomes between DES and BMS for the treatment of bifurcation lesions. METHODS: From April 2004 to October 2005, 291 Chinese patients [85.9% male, mean age (57.8 +/- 10.4) years] underwent DES (387 lesions) and/or BMS (297 lesions) implantation for bifurcation lesions. Clinical and angiographic follow-up was performed at 7 months. RESULTS: Compared with BMS group, patients in DES group had significantly lower rates of restenosis at main branch (9.5% vs 28.7%, P < 0.001) or side branch (14.5% vs 37.0%, P < 0.001) and major adverse cardiac events (MACE) (14.0% vs 26.3%, P = 0.000). The occurrence rate of late in-stent thrombosis did not differ between the two groups in both main (0.8% vs 0, P = 0.224) and side branches (1.4% vs 0, P = 0.198). Target lesion revascularization (TLR) was less frequent in DES group for main branch (8.3% vs 21.3%, P < 0.001) and for side branch (7.6% vs 23.5%, P < 0.001). Multivariate regression analysis revealed that total stent length (OR = 1.029, P = 0.01), postprocedural in-stent minimum lumen diameter (OR = 0.476, P = 0.03) and stent type (OR = 3.988, P = 0.0001) were independent predictors of TLR for main branch. Prior history of coronary intervention (OR = 2.424, P = 0.041), angulated lesion (OR = 2.337, P = 0.033), postdilation (OR = 0.267, P = 0.035) and stent type (DES vs BMS, OR = 5.459, P = 0.000) were independent predictors of TLR for side branch. CONCLUSION: The implantation of DES may be associated with greater reduction of restenosis and TLR than BMS in bifurcations angioplasty. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/16863606/Comparison_of_drug_eluting_stents_with_bare_metal_stents_in_daily_practice_for_bifurcation_lesions_in_Chinese_patients_ L2 - http://Insights.ovid.com/pubmed?pmid=16863606 DB - PRIME DP - Unbound Medicine ER -