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Detection of mutagens in water-distribution systems after disinfection.
Mutat Res. 2006 Sep 19; 608(1):72-81.MR

Abstract

This research examined the quality of water-before and after distribution-of four drinking-water production plants located in Northern Italy, two of which collected water from local aquifers and two from the River Po. A battery of genotoxicity assays for monitoring drinking-water was performed to assess the quality of the water produced by the treatment plants under study. Three different sampling stations were selected at each plant, one right at the outlet of the treatment plant and two along with the distribution pipelines. Raw river water was also sampled and analysed as a control. The water samples (500 l) were concentrated on silica C18 cartridges and the extracts were tested in in vitro mutagenicity assays (Salmonella/microsome assay with strains TA 98 and TA 100; SOS Chromotest with Escherichia coli strain PQ37); gene conversion, point mutation and mitochondrial DNA mutability assays with the diploid Saccharomyces cerevisiae strain D7 and a toxicity test using the bioluminescent bacterium Vibrio fischeri (Microtox). The Microtox test and the mitochondrial DNA mutability assay showed the greatest sensitivity towards toxic or mutagenic substances in the water extracts considered. The results show that this battery of short-term tests is applicable in the routine monitoring of drinking-water quality before and after distribution.

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Authors+Show Affiliations

Guzzella L
Water Research Institute-National Research Council (IRSA-CNR), via della Mornera 25, 20047 Brugherio, Milan, Italy. guzzella@irsa.cnr.it
Di Caterino F
No affiliation info available
Monarca S
No affiliation info available
Zani C
No affiliation info available
Feretti D
No affiliation info available
Zerbini I
No affiliation info available
Nardi G
No affiliation info available
Buschini A
No affiliation info available
Poli P
No affiliation info available
Rossi C
No affiliation info available

MeSH

AnimalsDNA, MitochondrialItalyMicrosomes, LiverMutagenicity TestsMutagensRatsSaccharomyces cerevisiaeSalmonella typhimuriumSensitivity and SpecificityWaterWater Purification

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16863700

Citation

Guzzella, Licia, et al. "Detection of Mutagens in Water-distribution Systems After Disinfection." Mutation Research, vol. 608, no. 1, 2006, pp. 72-81.
Guzzella L, Di Caterino F, Monarca S, et al. Detection of mutagens in water-distribution systems after disinfection. Mutat Res. 2006;608(1):72-81.
Guzzella, L., Di Caterino, F., Monarca, S., Zani, C., Feretti, D., Zerbini, I., Nardi, G., Buschini, A., Poli, P., & Rossi, C. (2006). Detection of mutagens in water-distribution systems after disinfection. Mutation Research, 608(1), 72-81.
Guzzella L, et al. Detection of Mutagens in Water-distribution Systems After Disinfection. Mutat Res. 2006 Sep 19;608(1):72-81. PubMed PMID: 16863700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of mutagens in water-distribution systems after disinfection. AU - Guzzella,Licia, AU - Di Caterino,Filomena, AU - Monarca,Silvano, AU - Zani,Claudia, AU - Feretti,Donatella, AU - Zerbini,Ilaria, AU - Nardi,Giuseppe, AU - Buschini,Annamaria, AU - Poli,Paola, AU - Rossi,Carlo, Y1 - 2006/07/25/ PY - 2006/01/18/received PY - 2006/03/28/revised PY - 2006/05/05/accepted PY - 2006/7/26/pubmed PY - 2006/10/13/medline PY - 2006/7/26/entrez SP - 72 EP - 81 JF - Mutation research JO - Mutat Res VL - 608 IS - 1 N2 - This research examined the quality of water-before and after distribution-of four drinking-water production plants located in Northern Italy, two of which collected water from local aquifers and two from the River Po. A battery of genotoxicity assays for monitoring drinking-water was performed to assess the quality of the water produced by the treatment plants under study. Three different sampling stations were selected at each plant, one right at the outlet of the treatment plant and two along with the distribution pipelines. Raw river water was also sampled and analysed as a control. The water samples (500 l) were concentrated on silica C18 cartridges and the extracts were tested in in vitro mutagenicity assays (Salmonella/microsome assay with strains TA 98 and TA 100; SOS Chromotest with Escherichia coli strain PQ37); gene conversion, point mutation and mitochondrial DNA mutability assays with the diploid Saccharomyces cerevisiae strain D7 and a toxicity test using the bioluminescent bacterium Vibrio fischeri (Microtox). The Microtox test and the mitochondrial DNA mutability assay showed the greatest sensitivity towards toxic or mutagenic substances in the water extracts considered. The results show that this battery of short-term tests is applicable in the routine monitoring of drinking-water quality before and after distribution. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/16863700/Detection_of_mutagens_in_water_distribution_systems_after_disinfection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1383-5718(06)00157-4 DB - PRIME DP - Unbound Medicine ER -