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Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease.
Neurology. 2006 Jul 25; 67(2):315-8.Neur

Abstract

BACKGROUND

Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson disease (PD), through neurotoxic effects. Higher dietary intakes of folate, vitamin B12, and vitamin B6 (cofactors in homocysteine metabolism) might decrease the risk of PD through decreasing plasma homocysteine. Moreover, vitamin B6 might influence the risk of PD through antioxidant effects unrelated to homocysteine metabolism and through its role in dopamine synthesis.

METHODS

In the Rotterdam Study, a prospective, population-based cohort study of people aged 55 years and older, the authors evaluated the association between dietary intake of folate, vitamin B12, and vitamin B6 and the risk of incident PD among 5,289 participants who were free of dementia and parkinsonism and underwent complete dietary assessment at baseline. PD was assessed through repeated in-person examination and continuous monitoring by computer linkage to medical records. Data were analyzed using Cox proportional hazards regression analysis.

RESULTS

After a mean follow-up of 9.7 years, the authors identified 72 participants with incident PD. Higher dietary intake of vitamin B6 was associated with a significantly decreased risk of PD (hazard ratio per SD, 0.69 [95% CI 0.50 to 0.96]; for highest vs lowest tertile, 0.46 [0.22 to 0.96]). Stratified analyses showed that this association was restricted to smokers. No association was observed for dietary folate and vitamin B(12).

CONCLUSIONS

Dietary vitamin B6 may decrease the risk of Parkinson disease, probably through mechanisms unrelated to homocysteine metabolism.

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Authors+Show Affiliations

de Lau LM
Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands. m.breteler@erasmusmc.nl
Koudstaal PJ
No affiliation info available
Witteman JC
No affiliation info available
Hofman A
No affiliation info available
Breteler MM
No affiliation info available

MeSH

Administration, OralCohort StudiesDiet TherapyDietary SupplementsFemaleFolic AcidHumansIncidenceMaleMiddle AgedNetherlandsParkinson DiseaseRisk AssessmentRisk FactorsTreatment OutcomeVitamin B 12Vitamin B 6

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16864826

Citation

de Lau, L M L., et al. "Dietary Folate, Vitamin B12, and Vitamin B6 and the Risk of Parkinson Disease." Neurology, vol. 67, no. 2, 2006, pp. 315-8.
de Lau LM, Koudstaal PJ, Witteman JC, et al. Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. Neurology. 2006;67(2):315-8.
de Lau, L. M., Koudstaal, P. J., Witteman, J. C., Hofman, A., & Breteler, M. M. (2006). Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. Neurology, 67(2), 315-8.
de Lau LM, et al. Dietary Folate, Vitamin B12, and Vitamin B6 and the Risk of Parkinson Disease. Neurology. 2006 Jul 25;67(2):315-8. PubMed PMID: 16864826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. AU - de Lau,L M L, AU - Koudstaal,P J, AU - Witteman,J C M, AU - Hofman,A, AU - Breteler,M M B, PY - 2006/7/26/pubmed PY - 2006/8/15/medline PY - 2006/7/26/entrez SP - 315 EP - 8 JF - Neurology JO - Neurology VL - 67 IS - 2 N2 - BACKGROUND: Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson disease (PD), through neurotoxic effects. Higher dietary intakes of folate, vitamin B12, and vitamin B6 (cofactors in homocysteine metabolism) might decrease the risk of PD through decreasing plasma homocysteine. Moreover, vitamin B6 might influence the risk of PD through antioxidant effects unrelated to homocysteine metabolism and through its role in dopamine synthesis. METHODS: In the Rotterdam Study, a prospective, population-based cohort study of people aged 55 years and older, the authors evaluated the association between dietary intake of folate, vitamin B12, and vitamin B6 and the risk of incident PD among 5,289 participants who were free of dementia and parkinsonism and underwent complete dietary assessment at baseline. PD was assessed through repeated in-person examination and continuous monitoring by computer linkage to medical records. Data were analyzed using Cox proportional hazards regression analysis. RESULTS: After a mean follow-up of 9.7 years, the authors identified 72 participants with incident PD. Higher dietary intake of vitamin B6 was associated with a significantly decreased risk of PD (hazard ratio per SD, 0.69 [95% CI 0.50 to 0.96]; for highest vs lowest tertile, 0.46 [0.22 to 0.96]). Stratified analyses showed that this association was restricted to smokers. No association was observed for dietary folate and vitamin B(12). CONCLUSIONS: Dietary vitamin B6 may decrease the risk of Parkinson disease, probably through mechanisms unrelated to homocysteine metabolism. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16864826/Dietary_folate_vitamin_B12_and_vitamin_B6_and_the_risk_of_Parkinson_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16864826 DB - PRIME DP - Unbound Medicine ER -