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The effects of hydroxyethyl starch solution in critically ill patients.
Minerva Anestesiol. 2006 Jul-Aug; 72(7-8):655-64.MA

Abstract

AIM

In the treatment of the critically ill patients an adequate fluid therapy appears to be essential to optimize hemodynamics and to get a suitable tissue perfusion. In this study we have evaluated the effects of volume replacement, carried out with 2 different solutions: hydroxyethyl starch 6% (HAES) and albumin 20% (HA).

METHODS

Twenty patients suffering from sepsis were recruited and randomized into 2 groups. The first group was treated with hydroxyethyl starch 6% (HAES treated group), and the second with albumin 20% (HA treated group). The volume of colloids was given to maintain pulmonary capillary wedge pressure (PCWP) between 15 and 18 mmHg. Daily, both hemodynamic parameters and blood gas analyses were monitored.

RESULTS

Groups were homogeneous for age, sex and pathology. During the treatment we observed that cardiac index (CI), right ventricular ejection fraction (RVEF), oxygen consumption index (VO(2)I), oxygen delivery index (DO(2)I), and rate between arterial oxygen pressure and fraction of inspired oxygen (PaO(2)/FiO(2)) were increased significantly only in HAES treated group (P<0.05). APACHE II score decreased significantly only in HAES treated group (P<0.05), contrarily to the HA treated group, in which we observed a non significant increase.

CONCLUSIONS

Since hydroxyethyl starch induced a hemodynamic and clinical improvement, these effects translated into an improvement of sensorium and a reduction of APACHE II score, without causing pulmonary edema, we can conclude that hydroxyethyl starch 6% ws 130,000 dalton ms 0.4 (Voluven) is an effective fluid for resuscitation of hypovolemic patients and represent an attractive alternative to albumin.

Authors+Show Affiliations

Department of Surgical, Anesthesiological Intensive Care and Emergency Sciences, Federico II University of Naples, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng ita

PubMed ID

16865084

Citation

Palumbo, D, et al. "The Effects of Hydroxyethyl Starch Solution in Critically Ill Patients." Minerva Anestesiologica, vol. 72, no. 7-8, 2006, pp. 655-64.
Palumbo D, Servillo G, D'Amato L, et al. The effects of hydroxyethyl starch solution in critically ill patients. Minerva Anestesiol. 2006;72(7-8):655-64.
Palumbo, D., Servillo, G., D'Amato, L., Volpe, M. L., Capogrosso, G., De Robertis, E., Piazza, O., & Tufano, R. (2006). The effects of hydroxyethyl starch solution in critically ill patients. Minerva Anestesiologica, 72(7-8), 655-64.
Palumbo D, et al. The Effects of Hydroxyethyl Starch Solution in Critically Ill Patients. Minerva Anestesiol. 2006 Jul-Aug;72(7-8):655-64. PubMed PMID: 16865084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of hydroxyethyl starch solution in critically ill patients. AU - Palumbo,D, AU - Servillo,G, AU - D'Amato,L, AU - Volpe,M L, AU - Capogrosso,G, AU - De Robertis,E, AU - Piazza,O, AU - Tufano,R, PY - 2006/7/26/pubmed PY - 2006/10/13/medline PY - 2006/7/26/entrez SP - 655 EP - 64 JF - Minerva anestesiologica JO - Minerva Anestesiol VL - 72 IS - 7-8 N2 - AIM: In the treatment of the critically ill patients an adequate fluid therapy appears to be essential to optimize hemodynamics and to get a suitable tissue perfusion. In this study we have evaluated the effects of volume replacement, carried out with 2 different solutions: hydroxyethyl starch 6% (HAES) and albumin 20% (HA). METHODS: Twenty patients suffering from sepsis were recruited and randomized into 2 groups. The first group was treated with hydroxyethyl starch 6% (HAES treated group), and the second with albumin 20% (HA treated group). The volume of colloids was given to maintain pulmonary capillary wedge pressure (PCWP) between 15 and 18 mmHg. Daily, both hemodynamic parameters and blood gas analyses were monitored. RESULTS: Groups were homogeneous for age, sex and pathology. During the treatment we observed that cardiac index (CI), right ventricular ejection fraction (RVEF), oxygen consumption index (VO(2)I), oxygen delivery index (DO(2)I), and rate between arterial oxygen pressure and fraction of inspired oxygen (PaO(2)/FiO(2)) were increased significantly only in HAES treated group (P<0.05). APACHE II score decreased significantly only in HAES treated group (P<0.05), contrarily to the HA treated group, in which we observed a non significant increase. CONCLUSIONS: Since hydroxyethyl starch induced a hemodynamic and clinical improvement, these effects translated into an improvement of sensorium and a reduction of APACHE II score, without causing pulmonary edema, we can conclude that hydroxyethyl starch 6% ws 130,000 dalton ms 0.4 (Voluven) is an effective fluid for resuscitation of hypovolemic patients and represent an attractive alternative to albumin. SN - 0375-9393 UR - https://www.unboundmedicine.com/medline/citation/16865084/The_effects_of_hydroxyethyl_starch_solution_in_critically_ill_patients_ L2 - http://www.minervamedica.it/index2.t?show=R02Y2006N07A0655 DB - PRIME DP - Unbound Medicine ER -