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Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats.

Abstract

INTRODUCTION

The aim of the study is to analyse the antioxidant effect of oral administration of aqueous extract of Annona squamosa (A. squamosa) leaf on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, antioxidant enzymes and lipid peroxidation in liver and kidney to streptozotocin (STZ)-induced diabetic rats.

METHODS

Aqueous extract of A. squamosa on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, serum lipid and the levels of lipid peroxides and antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione, were examined in the liver and kidney tissues of control and experimental groups.

RESULTS

Oral administration of A. squamosa aqueous extract to diabetic rats for 30 days significantly reduced the levels of blood glucose, lipids and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes, like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase.

CONCLUSION

The A. squamosa aqueous extract supplementation is useful in controlling the blood glucose level, improves the plasma insulin, lipid metabolism and is beneficial in preventing diabetic complications from lipid peroxidation and antioxidant systems in experimental diabetic rats; therefore, it could be useful for prevention or early treatment of diabetes mellitus.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India. kaleem_biochem@yahoo.com

    , ,

    Source

    Singapore medical journal 47:8 2006 Aug pg 670-5

    MeSH

    Animals
    Annona
    Antioxidants
    Blood Glucose
    Cholesterol
    Diabetes Mellitus, Experimental
    Glycated Hemoglobin A
    Hypoglycemic Agents
    Insulin
    Male
    Oxidative Stress
    Phytotherapy
    Plant Extracts
    Rats
    Rats, Wistar
    Streptozocin

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16865205

    Citation

    Kaleem, M, et al. "Antidiabetic and Antioxidant Activity of Annona Squamosa Extract in Streptozotocin-induced Diabetic Rats." Singapore Medical Journal, vol. 47, no. 8, 2006, pp. 670-5.
    Kaleem M, Asif M, Ahmed QU, et al. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2006;47(8):670-5.
    Kaleem, M., Asif, M., Ahmed, Q. U., & Bano, B. (2006). Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Medical Journal, 47(8), pp. 670-5.
    Kaleem M, et al. Antidiabetic and Antioxidant Activity of Annona Squamosa Extract in Streptozotocin-induced Diabetic Rats. Singapore Med J. 2006;47(8):670-5. PubMed PMID: 16865205.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. AU - Kaleem,M, AU - Asif,M, AU - Ahmed,Q U, AU - Bano,B, PY - 2006/7/26/pubmed PY - 2006/10/13/medline PY - 2006/7/26/entrez SP - 670 EP - 5 JF - Singapore medical journal JO - Singapore Med J VL - 47 IS - 8 N2 - INTRODUCTION: The aim of the study is to analyse the antioxidant effect of oral administration of aqueous extract of Annona squamosa (A. squamosa) leaf on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, antioxidant enzymes and lipid peroxidation in liver and kidney to streptozotocin (STZ)-induced diabetic rats. METHODS: Aqueous extract of A. squamosa on blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, serum lipid and the levels of lipid peroxides and antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione, were examined in the liver and kidney tissues of control and experimental groups. RESULTS: Oral administration of A. squamosa aqueous extract to diabetic rats for 30 days significantly reduced the levels of blood glucose, lipids and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes, like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase. CONCLUSION: The A. squamosa aqueous extract supplementation is useful in controlling the blood glucose level, improves the plasma insulin, lipid metabolism and is beneficial in preventing diabetic complications from lipid peroxidation and antioxidant systems in experimental diabetic rats; therefore, it could be useful for prevention or early treatment of diabetes mellitus. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/16865205/Antidiabetic_and_antioxidant_activity_of_Annona_squamosa_extract_in_streptozotocin_induced_diabetic_rats_ L2 - http://www.sma.org.sg/smj/4708/4708a2.pdf DB - PRIME DP - Unbound Medicine ER -