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Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation?
J Assist Reprod Genet. 2006 Jun; 23(6):289-92.JA

Abstract

PURPOSE

This study was performed to evaluate whether a lower dose (0.2 mg) of cetrorelix would prevent premature LH surge in patients undergoing controlled ovarian hyperstimulation.

METHODS

Controlled ovarian hyperstimulation was carried out in 45 patients, starting on menstrual cycle day 3 with recombinant FSH (r-FSH), and a cetrorelix of 0.2 mg was administered from day 5 evening of ovarian stimulation until the day before hCG injection.

RESULTS

There was a statistically significant decrease in serum LH level one day after the first cetrorelix injection and on the day of hCG administration. Serum LH concentrations were maintained constantly low during the follicular phase with no premature LH surge occurring in any of the patients. Clinical pregnancy was achieved for 18 women (40%), with one of these experiencing intrauterine fetal death before 12 week' gestation.

CONCLUSION

This study demonstrates that a daily dose of cetrorelix 0.2 mg is able to prevent premature LH surge.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Shih Lin District, Taipei, 111, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16865530

Citation

Chen, Heng-Ju, et al. "Is a Lower Dose of Cetrorelix Acetate Effective for Prevention of LH Surge During Controlled Ovarian Hyperstimulation?" Journal of Assisted Reproduction and Genetics, vol. 23, no. 6, 2006, pp. 289-92.
Chen HJ, Lin YH, Hsieh BC, et al. Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation? J Assist Reprod Genet. 2006;23(6):289-92.
Chen, H. J., Lin, Y. H., Hsieh, B. C., Seow, K. M., Hwang, J. L., & Tzeng, C. R. (2006). Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation? Journal of Assisted Reproduction and Genetics, 23(6), 289-92.
Chen HJ, et al. Is a Lower Dose of Cetrorelix Acetate Effective for Prevention of LH Surge During Controlled Ovarian Hyperstimulation. J Assist Reprod Genet. 2006;23(6):289-92. PubMed PMID: 16865530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation? AU - Chen,Heng-Ju, AU - Lin,Yu-Hung, AU - Hsieh,Bih-Chwen, AU - Seow,Kok-Min, AU - Hwang,Jiann-Loung, AU - Tzeng,Chii-Ruey, Y1 - 2006/07/22/ PY - 2006/03/04/received PY - 2006/05/23/accepted PY - 2006/7/26/pubmed PY - 2006/11/15/medline PY - 2006/7/26/entrez SP - 289 EP - 92 JF - Journal of assisted reproduction and genetics JO - J. Assist. Reprod. Genet. VL - 23 IS - 6 N2 - PURPOSE: This study was performed to evaluate whether a lower dose (0.2 mg) of cetrorelix would prevent premature LH surge in patients undergoing controlled ovarian hyperstimulation. METHODS: Controlled ovarian hyperstimulation was carried out in 45 patients, starting on menstrual cycle day 3 with recombinant FSH (r-FSH), and a cetrorelix of 0.2 mg was administered from day 5 evening of ovarian stimulation until the day before hCG injection. RESULTS: There was a statistically significant decrease in serum LH level one day after the first cetrorelix injection and on the day of hCG administration. Serum LH concentrations were maintained constantly low during the follicular phase with no premature LH surge occurring in any of the patients. Clinical pregnancy was achieved for 18 women (40%), with one of these experiencing intrauterine fetal death before 12 week' gestation. CONCLUSION: This study demonstrates that a daily dose of cetrorelix 0.2 mg is able to prevent premature LH surge. SN - 1058-0468 UR - https://www.unboundmedicine.com/medline/citation/16865530/Is_a_lower_dose_of_cetrorelix_acetate_effective_for_prevention_of_LH_surge_during_controlled_ovarian_hyperstimulation L2 - https://doi.org/10.1007/s10815-006-9054-0 DB - PRIME DP - Unbound Medicine ER -