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Endogenous sex hormones, cognitive decline, and future dementia in old men.
Ann Neurol. 2006 Sep; 60(3):346-55.AN

Abstract

OBJECTIVE

To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men.

METHODS

Within the population-based, prospective Honolulu-Asia Aging Study, 2,974 men, aged 71 to 93 years, without dementia were reexamined 3 times over an average of 6 years for development of dementia and cognitive decline. Cognitive decline was measured with the Cognitive Abilities Screening Instrument. Incident dementia was diagnosed according to standard criteria. A total of 134 men experienced development of Alzheimer's disease (AD; including 40 cases with contributing cerebrovascular disease) and 44 experienced development of vascular dementia.

RESULTS

Adjusting for age and other covariates, testosterone was not associated with risk for dementia (using Cox regression analyses) or cognitive decline (using random coefficient analyses). However, higher levels of estradiol were associated with risk for AD (hazard ratio per standard deviation increase, 1.25; 95% confidence interval, 1.05-1.47) and AD with cerebrovascular disease (hazard ratio, 1.19; 95% confidence interval, 1.02-1.38). Also, compared with the lowest tertile of estradiol, men in the middle and highest tertile of estradiol had 0.24 and 0.28 points lower Cognitive Abilities Screening Instrument scores, respectively, for each year increase in age.

INTERPRETATION

In old men, endogenous testosterone levels are not associated with risk for cognitive decline and AD, whereas higher estrogen levels increase risk for cognitive decline and AD.

Authors+Show Affiliations

University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands. m.geerlings@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16865684

Citation

Geerlings, Mirjam I., et al. "Endogenous Sex Hormones, Cognitive Decline, and Future Dementia in Old Men." Annals of Neurology, vol. 60, no. 3, 2006, pp. 346-55.
Geerlings MI, Strozyk D, Masaki K, et al. Endogenous sex hormones, cognitive decline, and future dementia in old men. Ann Neurol. 2006;60(3):346-55.
Geerlings, M. I., Strozyk, D., Masaki, K., Remaley, A. T., Petrovitch, H., Ross, G. W., White, L. R., & Launer, L. J. (2006). Endogenous sex hormones, cognitive decline, and future dementia in old men. Annals of Neurology, 60(3), 346-55.
Geerlings MI, et al. Endogenous Sex Hormones, Cognitive Decline, and Future Dementia in Old Men. Ann Neurol. 2006;60(3):346-55. PubMed PMID: 16865684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous sex hormones, cognitive decline, and future dementia in old men. AU - Geerlings,Mirjam I, AU - Strozyk,Dorothea, AU - Masaki,Kamal, AU - Remaley,Alan T, AU - Petrovitch,Helen, AU - Ross,G Webster, AU - White,Lon R, AU - Launer,Lenore J, PY - 2006/7/26/pubmed PY - 2006/11/15/medline PY - 2006/7/26/entrez SP - 346 EP - 55 JF - Annals of neurology JO - Ann. Neurol. VL - 60 IS - 3 N2 - OBJECTIVE: To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men. METHODS: Within the population-based, prospective Honolulu-Asia Aging Study, 2,974 men, aged 71 to 93 years, without dementia were reexamined 3 times over an average of 6 years for development of dementia and cognitive decline. Cognitive decline was measured with the Cognitive Abilities Screening Instrument. Incident dementia was diagnosed according to standard criteria. A total of 134 men experienced development of Alzheimer's disease (AD; including 40 cases with contributing cerebrovascular disease) and 44 experienced development of vascular dementia. RESULTS: Adjusting for age and other covariates, testosterone was not associated with risk for dementia (using Cox regression analyses) or cognitive decline (using random coefficient analyses). However, higher levels of estradiol were associated with risk for AD (hazard ratio per standard deviation increase, 1.25; 95% confidence interval, 1.05-1.47) and AD with cerebrovascular disease (hazard ratio, 1.19; 95% confidence interval, 1.02-1.38). Also, compared with the lowest tertile of estradiol, men in the middle and highest tertile of estradiol had 0.24 and 0.28 points lower Cognitive Abilities Screening Instrument scores, respectively, for each year increase in age. INTERPRETATION: In old men, endogenous testosterone levels are not associated with risk for cognitive decline and AD, whereas higher estrogen levels increase risk for cognitive decline and AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16865684/Endogenous_sex_hormones_cognitive_decline_and_future_dementia_in_old_men_ L2 - https://doi.org/10.1002/ana.20918 DB - PRIME DP - Unbound Medicine ER -