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Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China.
Tissue Antigens. 2006 Aug; 68(2):163-6.TA

Abstract

This study was to investigate the frequency of HLA-B27 and its subtypes in the Han population of Hunan province, southern China. One hundred and sixty-nine healthy unrelated donors were tested for HLA-B27 by polymerase chain reaction-sequence-specific primer (PCR-SSP). One hundred and twenty-eight B27-positive spondyloarthropathy patients and 18 B27-positive healthy controls were subtyped using the high-resolution PCR-SSP. The phenotype frequency of human leukocyte antigen (HLA)-B27 was found to be 2.36% in healthy population. Five B27 alleles were identified: B*2704, B*2705, B*2706, B*2707, and B*2724. No significant difference was found in the distribution of HLA-B27 subtypes between the patients and controls studied. Notably, B*2724 was observed in a juvenile patient with ankylosing spondylitis. This subtype has not been previously reported in Chinese ankylosing spondylitis (AS) patients and other ethnic groups.

Authors+Show Affiliations

Ma HJ
Department of Immunology, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, China.
Hu FP
No affiliation info available

MeSH

AsiansCase-Control StudiesChinaEthnicityGenetic Predisposition to DiseaseHLA-B27 AntigenHumansPolymerase Chain ReactionPolymorphism, GeneticSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16866886

Citation

Ma, H-J, and F-P Hu. "Diversity of Human Leukocyte antigen-B27 Alleles in Han Population of Hunan Province, Southern China." Tissue Antigens, vol. 68, no. 2, 2006, pp. 163-6.
Ma HJ, Hu FP. Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China. Tissue Antigens. 2006;68(2):163-6.
Ma, H. J., & Hu, F. P. (2006). Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China. Tissue Antigens, 68(2), 163-6.
Ma HJ, Hu FP. Diversity of Human Leukocyte antigen-B27 Alleles in Han Population of Hunan Province, Southern China. Tissue Antigens. 2006;68(2):163-6. PubMed PMID: 16866886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China. AU - Ma,H-J, AU - Hu,F-P, PY - 2006/7/27/pubmed PY - 2006/8/19/medline PY - 2006/7/27/entrez SP - 163 EP - 6 JF - Tissue antigens JO - Tissue Antigens VL - 68 IS - 2 N2 - This study was to investigate the frequency of HLA-B27 and its subtypes in the Han population of Hunan province, southern China. One hundred and sixty-nine healthy unrelated donors were tested for HLA-B27 by polymerase chain reaction-sequence-specific primer (PCR-SSP). One hundred and twenty-eight B27-positive spondyloarthropathy patients and 18 B27-positive healthy controls were subtyped using the high-resolution PCR-SSP. The phenotype frequency of human leukocyte antigen (HLA)-B27 was found to be 2.36% in healthy population. Five B27 alleles were identified: B*2704, B*2705, B*2706, B*2707, and B*2724. No significant difference was found in the distribution of HLA-B27 subtypes between the patients and controls studied. Notably, B*2724 was observed in a juvenile patient with ankylosing spondylitis. This subtype has not been previously reported in Chinese ankylosing spondylitis (AS) patients and other ethnic groups. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/16866886/Diversity_of_human_leukocyte_antigen_B27_alleles_in_Han_population_of_Hunan_province_southern_China_ DB - PRIME DP - Unbound Medicine ER -