Tags

Type your tag names separated by a space and hit enter

Effect of prenatal and postnatal cocaine exposure on somatostatin content and binding in frontoparietal cortex and hippocampus of developing rat pups.
Peptides. 1991 Sep-Oct; 12(5):951-6.P

Abstract

The effects of cocaine administration to pregnant and/or nursing rats on somatostatin (SS) concentration and receptors in offspring brains at birth and 15 days of age were studied. SS was measured by radioimmunoassay and SS receptors by radio receptor assay in frontoparietal cortex and hippocampus. In newborn and 15-day-old animals the exposure to cocaine produced an increase in SS concentration in the frontoparietal cortex and a decrease of this parameter in the hippocampus. Administration of cocaine only during lactation did not induce such changes. Exposure during pregnancy or nursing induced in 0- or 15-day-old offspring an increase in the total number of SS receptors and a decrease in the affinity constant only in the cortex.

Authors+Show Affiliations

Rodríguez-Sánchez MN
Department of Biochemistry and Molecular Biology, Medical School, University of Alcalá, Madrid, Spain.
Alvaro I
No affiliation info available
Arilla E
No affiliation info available

MeSH

AgingAnimalsAnimals, NewbornBinding, CompetitiveCocaineFemaleHippocampusKineticsMaternal-Fetal ExchangeParietal LobePregnancyRadioimmunoassayRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1686936

Citation

Rodríguez-Sánchez, M N., et al. "Effect of Prenatal and Postnatal Cocaine Exposure On Somatostatin Content and Binding in Frontoparietal Cortex and Hippocampus of Developing Rat Pups." Peptides, vol. 12, no. 5, 1991, pp. 951-6.
Rodríguez-Sánchez MN, Alvaro I, Arilla E. Effect of prenatal and postnatal cocaine exposure on somatostatin content and binding in frontoparietal cortex and hippocampus of developing rat pups. Peptides. 1991;12(5):951-6.
Rodríguez-Sánchez, M. N., Alvaro, I., & Arilla, E. (1991). Effect of prenatal and postnatal cocaine exposure on somatostatin content and binding in frontoparietal cortex and hippocampus of developing rat pups. Peptides, 12(5), 951-6.
Rodríguez-Sánchez MN, Alvaro I, Arilla E. Effect of Prenatal and Postnatal Cocaine Exposure On Somatostatin Content and Binding in Frontoparietal Cortex and Hippocampus of Developing Rat Pups. Peptides. 1991 Sep-Oct;12(5):951-6. PubMed PMID: 1686936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of prenatal and postnatal cocaine exposure on somatostatin content and binding in frontoparietal cortex and hippocampus of developing rat pups. AU - Rodríguez-Sánchez,M N, AU - Alvaro,I, AU - Arilla,E, PY - 1991/9/1/pubmed PY - 1991/9/1/medline PY - 1991/9/1/entrez SP - 951 EP - 6 JF - Peptides JO - Peptides VL - 12 IS - 5 N2 - The effects of cocaine administration to pregnant and/or nursing rats on somatostatin (SS) concentration and receptors in offspring brains at birth and 15 days of age were studied. SS was measured by radioimmunoassay and SS receptors by radio receptor assay in frontoparietal cortex and hippocampus. In newborn and 15-day-old animals the exposure to cocaine produced an increase in SS concentration in the frontoparietal cortex and a decrease of this parameter in the hippocampus. Administration of cocaine only during lactation did not induce such changes. Exposure during pregnancy or nursing induced in 0- or 15-day-old offspring an increase in the total number of SS receptors and a decrease in the affinity constant only in the cortex. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/1686936/Effect_of_prenatal_and_postnatal_cocaine_exposure_on_somatostatin_content_and_binding_in_frontoparietal_cortex_and_hippocampus_of_developing_rat_pups_ DB - PRIME DP - Unbound Medicine ER -