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Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
Org Lett. 2006 Aug 03; 8(16):3513-6.OL

Abstract

[reaction: see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.

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Authors+Show Affiliations

Elban MA
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
Sun W
No affiliation info available
Eisenhauer BM
No affiliation info available
Gao R
No affiliation info available
Hecht SM
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCamptothecinDNADNA Topoisomerases, Type IDrug Screening Assays, AntitumorMolecular StructureStructure-Activity RelationshipTopoisomerase I Inhibitors

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16869648

Citation

Elban, Mark A., et al. "Synthesis and Biological Evaluation of 10,11-methylenedioxy-14-azacamptothecin." Organic Letters, vol. 8, no. 16, 2006, pp. 3513-6.
Elban MA, Sun W, Eisenhauer BM, et al. Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org Lett. 2006;8(16):3513-6.
Elban, M. A., Sun, W., Eisenhauer, B. M., Gao, R., & Hecht, S. M. (2006). Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Organic Letters, 8(16), 3513-6.
Elban MA, et al. Synthesis and Biological Evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org Lett. 2006 Aug 3;8(16):3513-6. PubMed PMID: 16869648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. AU - Elban,Mark A, AU - Sun,Wenyue, AU - Eisenhauer,Brian M, AU - Gao,Rong, AU - Hecht,Sidney M, PY - 2006/7/28/pubmed PY - 2007/6/7/medline PY - 2006/7/28/entrez SP - 3513 EP - 6 JF - Organic letters JO - Org Lett VL - 8 IS - 16 N2 - [reaction: see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16869648/Synthesis_and_biological_evaluation_of_1011_methylenedioxy_14_azacamptothecin_ L2 - https://doi.org/10.1021/ol0611604 DB - PRIME DP - Unbound Medicine ER -