Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.Org Lett. 2006 Aug 03; 8(16):3513-6.OL
Abstract
[reaction: see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Language
eng
PubMed ID
16869648
Citation
Elban, Mark A., et al. "Synthesis and Biological Evaluation of 10,11-methylenedioxy-14-azacamptothecin." Organic Letters, vol. 8, no. 16, 2006, pp. 3513-6.
Elban MA, Sun W, Eisenhauer BM, et al. Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org Lett. 2006;8(16):3513-6.
Elban, M. A., Sun, W., Eisenhauer, B. M., Gao, R., & Hecht, S. M. (2006). Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Organic Letters, 8(16), 3513-6.
Elban MA, et al. Synthesis and Biological Evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org Lett. 2006 Aug 3;8(16):3513-6. PubMed PMID: 16869648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
AU - Elban,Mark A,
AU - Sun,Wenyue,
AU - Eisenhauer,Brian M,
AU - Gao,Rong,
AU - Hecht,Sidney M,
PY - 2006/7/28/pubmed
PY - 2007/6/7/medline
PY - 2006/7/28/entrez
SP - 3513
EP - 6
JF - Organic letters
JO - Org Lett
VL - 8
IS - 16
N2 - [reaction: see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.
SN - 1523-7060
UR - https://www.unboundmedicine.com/medline/citation/16869648/Synthesis_and_biological_evaluation_of_1011_methylenedioxy_14_azacamptothecin_
L2 - https://doi.org/10.1021/ol0611604
DB - PRIME
DP - Unbound Medicine
ER -