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Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
Org Lett. 2006 Aug 03; 8(16):3513-6.OL

Abstract

[reaction: see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.

Authors+Show Affiliations

Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16869648

Citation

Elban, Mark A., et al. "Synthesis and Biological Evaluation of 10,11-methylenedioxy-14-azacamptothecin." Organic Letters, vol. 8, no. 16, 2006, pp. 3513-6.
Elban MA, Sun W, Eisenhauer BM, et al. Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org Lett. 2006;8(16):3513-6.
Elban, M. A., Sun, W., Eisenhauer, B. M., Gao, R., & Hecht, S. M. (2006). Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. Organic Letters, 8(16), 3513-6.
Elban MA, et al. Synthesis and Biological Evaluation of 10,11-methylenedioxy-14-azacamptothecin. Org Lett. 2006 Aug 3;8(16):3513-6. PubMed PMID: 16869648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin. AU - Elban,Mark A, AU - Sun,Wenyue, AU - Eisenhauer,Brian M, AU - Gao,Rong, AU - Hecht,Sidney M, PY - 2006/7/28/pubmed PY - 2007/6/7/medline PY - 2006/7/28/entrez SP - 3513 EP - 6 JF - Organic letters JO - Org. Lett. VL - 8 IS - 16 N2 - [reaction: see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16869648/Synthesis_and_biological_evaluation_of_1011_methylenedioxy_14_azacamptothecin_ L2 - https://dx.doi.org/10.1021/ol0611604 DB - PRIME DP - Unbound Medicine ER -