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Synthesis and antitumor activity of novel 10-substituted camptothecin analogues.
Bioorg Med Chem. 2006 Nov 01; 14(21):7175-82.BM

Abstract

In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell lines and antitumor activity in vivo, and inhibitory properties of topoisomerase I of these derivatives were evaluated. Most of these derivatives possessed lower cytotoxicities than CPT, and the compounds 13, 21, 22, 23, and 24 showed similar topoisomerase I inhibitory activity to CPT. Analogues 13 exhibited the best antitumor activity in vivo among all derivatives we prepared.

Authors+Show Affiliations

Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16870453

Citation

Li, Qingyong, et al. "Synthesis and Antitumor Activity of Novel 10-substituted Camptothecin Analogues." Bioorganic & Medicinal Chemistry, vol. 14, no. 21, 2006, pp. 7175-82.
Li Q, Zu Y, Shi R, et al. Synthesis and antitumor activity of novel 10-substituted camptothecin analogues. Bioorg Med Chem. 2006;14(21):7175-82.
Li, Q., Zu, Y., Shi, R., Yao, L., Fu, Y., Yang, Z., & Li, L. (2006). Synthesis and antitumor activity of novel 10-substituted camptothecin analogues. Bioorganic & Medicinal Chemistry, 14(21), 7175-82.
Li Q, et al. Synthesis and Antitumor Activity of Novel 10-substituted Camptothecin Analogues. Bioorg Med Chem. 2006 Nov 1;14(21):7175-82. PubMed PMID: 16870453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and antitumor activity of novel 10-substituted camptothecin analogues. AU - Li,Qingyong, AU - Zu,Yuangang, AU - Shi,Rongzhen, AU - Yao,Liping, AU - Fu,Yujie, AU - Yang,Zhiwei, AU - Li,Lei, Y1 - 2006/07/25/ PY - 2006/02/19/received PY - 2006/06/23/revised PY - 2006/06/24/accepted PY - 2006/7/28/pubmed PY - 2006/12/27/medline PY - 2006/7/28/entrez SP - 7175 EP - 82 JF - Bioorganic & medicinal chemistry JO - Bioorg. Med. Chem. VL - 14 IS - 21 N2 - In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell lines and antitumor activity in vivo, and inhibitory properties of topoisomerase I of these derivatives were evaluated. Most of these derivatives possessed lower cytotoxicities than CPT, and the compounds 13, 21, 22, 23, and 24 showed similar topoisomerase I inhibitory activity to CPT. Analogues 13 exhibited the best antitumor activity in vivo among all derivatives we prepared. SN - 0968-0896 UR - https://www.unboundmedicine.com/medline/citation/16870453/Synthesis_and_antitumor_activity_of_novel_10_substituted_camptothecin_analogues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(06)00535-9 DB - PRIME DP - Unbound Medicine ER -