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Current clinical applications of omega-6 and omega-3 fatty acids.
Nutr Clin Pract 2006; 21(4):323-41NC

Abstract

BACKGROUND

Recent years have brought a resurgence of research interest in fatty acids, with studied fields running the gamut of human disease. This movement has run in parallel with an increased interest in using nutrition modalities as therapeutic measures, as opposed to their conventional role as energy sources. The aim of this manuscript is to provide a basic review of current clinical applications of omega-6 and omega-3 fatty acids, with a particular focus on the latter.

METHODS

A selective review of the voluminous literature, including randomized controlled trials, meta-analyses, population studies, and case reports, was used to compile data and identify trends in pertinent clinical applications of fatty acid therapy.

CONCLUSIONS

There are a myriad of disorders and maladies that seem to benefit from fatty acid supplementation, specifically omega-3 fatty acids. It has clearly been shown that omega-3 fatty acid supplementation provides a protective benefit in heart disease, and in particular sudden cardiac death. Rheumatoid arthritis (RA) is another disease entity that has been proven to benefit from this nutrition intervention, with improvement in symptoms and diminished nonsteroidal antiinflammatory drug (NSAID) usage. In addition, many psychiatric disorders, particularly schizophrenia and major depressive disorder (MDD), have shown positive results when supplementation has been used as an adjunct to standard pharmacotherapy. The remainder of clinical applications for omega-3 fatty acids requires further investigation. Specifically, according to preliminary clinical evidence, parenteral administration of fatty acids warrants further study.

Authors+Show Affiliations

Children's Hospital Boston, 300 Longwood Ave., MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

16870801

Citation

Lee, Sang, et al. "Current Clinical Applications of Omega-6 and Omega-3 Fatty Acids." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 21, no. 4, 2006, pp. 323-41.
Lee S, Gura KM, Kim S, et al. Current clinical applications of omega-6 and omega-3 fatty acids. Nutr Clin Pract. 2006;21(4):323-41.
Lee, S., Gura, K. M., Kim, S., Arsenault, D. A., Bistrian, B. R., & Puder, M. (2006). Current clinical applications of omega-6 and omega-3 fatty acids. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 21(4), pp. 323-41.
Lee S, et al. Current Clinical Applications of Omega-6 and Omega-3 Fatty Acids. Nutr Clin Pract. 2006;21(4):323-41. PubMed PMID: 16870801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current clinical applications of omega-6 and omega-3 fatty acids. AU - Lee,Sang, AU - Gura,Kathleen M, AU - Kim,Sendia, AU - Arsenault,Danielle A, AU - Bistrian,Bruce R, AU - Puder,Mark, PY - 2006/7/28/pubmed PY - 2006/12/9/medline PY - 2006/7/28/entrez SP - 323 EP - 41 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 21 IS - 4 N2 - BACKGROUND: Recent years have brought a resurgence of research interest in fatty acids, with studied fields running the gamut of human disease. This movement has run in parallel with an increased interest in using nutrition modalities as therapeutic measures, as opposed to their conventional role as energy sources. The aim of this manuscript is to provide a basic review of current clinical applications of omega-6 and omega-3 fatty acids, with a particular focus on the latter. METHODS: A selective review of the voluminous literature, including randomized controlled trials, meta-analyses, population studies, and case reports, was used to compile data and identify trends in pertinent clinical applications of fatty acid therapy. CONCLUSIONS: There are a myriad of disorders and maladies that seem to benefit from fatty acid supplementation, specifically omega-3 fatty acids. It has clearly been shown that omega-3 fatty acid supplementation provides a protective benefit in heart disease, and in particular sudden cardiac death. Rheumatoid arthritis (RA) is another disease entity that has been proven to benefit from this nutrition intervention, with improvement in symptoms and diminished nonsteroidal antiinflammatory drug (NSAID) usage. In addition, many psychiatric disorders, particularly schizophrenia and major depressive disorder (MDD), have shown positive results when supplementation has been used as an adjunct to standard pharmacotherapy. The remainder of clinical applications for omega-3 fatty acids requires further investigation. Specifically, according to preliminary clinical evidence, parenteral administration of fatty acids warrants further study. SN - 0884-5336 UR - https://www.unboundmedicine.com/medline/citation/16870801/Current_clinical_applications_of_omega_6_and_omega_3_fatty_acids_ L2 - https://doi.org/10.1177/0115426506021004323 DB - PRIME DP - Unbound Medicine ER -