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The man behind the eponym dermatology in historical perspective: Albert Sézary and the Sézary syndrome.
Am J Dermatopathol. 2006 Aug; 28(4):357-67.AJ

Abstract

In a series of papers from 1938 to 1949, Albert Sézary, a French dermatologist and syphilologist, described erythroderma with cellules monstrueuses (monster cells) in the skin and blood, which is now known as Sézary syndrome or Sézary disease. This historical note reprises the life and work of Sézary. It outlines his original reports and his thoughts about the pathogenesis of the disease as a reticulosis, and lists a composite classification of the reticuloses, which includes that of Sézary. We touch briefly on the articles that first used the terms Sézary reticulosis and Sézary syndrome and the changing concepts of the reticuloses and the reticuloendothelial system. We conclude that Sézary syndrome (Sézary disease, Sézary reticulosis) cannot be separated from mycosis fungoides clinically, histopathologically, hematologically, or viscerally and, therefore, is not a disease sui generis. Despite our conclusions, present day consensus defines Sézary disease clinically as a generalized pruritic erythroderma: histopathologically with an epidermal and dermal infiltrate, lymphadenopathy and visceral involvement all containing monster cells (Lutzner/Sézary cells) in the skin, peripheral blood, lymph nodes, and viscera, a disease different and separate from mycosis fungoides.

Authors

No affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article
Portrait

Language

eng

PubMed ID

16871044

Citation

Steffen, Charles. "The Man Behind the Eponym Dermatology in Historical Perspective: Albert Sézary and the Sézary Syndrome." The American Journal of Dermatopathology, vol. 28, no. 4, 2006, pp. 357-67.
Steffen C. The man behind the eponym dermatology in historical perspective: Albert Sézary and the Sézary syndrome. Am J Dermatopathol. 2006;28(4):357-67.
Steffen, C. (2006). The man behind the eponym dermatology in historical perspective: Albert Sézary and the Sézary syndrome. The American Journal of Dermatopathology, 28(4), 357-67.
Steffen C. The Man Behind the Eponym Dermatology in Historical Perspective: Albert Sézary and the Sézary Syndrome. Am J Dermatopathol. 2006;28(4):357-67. PubMed PMID: 16871044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The man behind the eponym dermatology in historical perspective: Albert Sézary and the Sézary syndrome. A1 - Steffen,Charles, PY - 2006/7/28/pubmed PY - 2007/1/31/medline PY - 2006/7/28/entrez SP - 357 EP - 67 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 28 IS - 4 N2 - In a series of papers from 1938 to 1949, Albert Sézary, a French dermatologist and syphilologist, described erythroderma with cellules monstrueuses (monster cells) in the skin and blood, which is now known as Sézary syndrome or Sézary disease. This historical note reprises the life and work of Sézary. It outlines his original reports and his thoughts about the pathogenesis of the disease as a reticulosis, and lists a composite classification of the reticuloses, which includes that of Sézary. We touch briefly on the articles that first used the terms Sézary reticulosis and Sézary syndrome and the changing concepts of the reticuloses and the reticuloendothelial system. We conclude that Sézary syndrome (Sézary disease, Sézary reticulosis) cannot be separated from mycosis fungoides clinically, histopathologically, hematologically, or viscerally and, therefore, is not a disease sui generis. Despite our conclusions, present day consensus defines Sézary disease clinically as a generalized pruritic erythroderma: histopathologically with an epidermal and dermal infiltrate, lymphadenopathy and visceral involvement all containing monster cells (Lutzner/Sézary cells) in the skin, peripheral blood, lymph nodes, and viscera, a disease different and separate from mycosis fungoides. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/16871044/The_man_behind_the_eponym_dermatology_in_historical_perspective:_Albert_Sézary_and_the_Sézary_syndrome_ L2 - http://dx.doi.org/10.1097/00000372-200608000-00014 DB - PRIME DP - Unbound Medicine ER -