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Developments in the pharmacotherapeutic management of osteoporosis.
Expert Opin Pharmacother. 2006 Aug; 7(12):1603-15.EO

Abstract

During the last two decades, several medications have been granted a marketing authorisation for the management of osteoporosis. Bisphosphonates are the most widely prescribed drugs in this area, worldwide. Alendronate and risedronate are given daily or weekly and have demonstrated their ability to reduce fracture rates at the spine and hip. Ibandronate has demonstrated spine antifracture efficacy with intervals between dosings greater than weekly. New developments in this class include intravenous administration of ibandronate or zoledronate, once every three months or once yearly. Raloxifene, a selective estrogen-receptor modulator, reduces spine fractures and, in post-hoc analyses, non-spine fractures in high-risk subjects. New selective estrogen-receptor modulators, including lasofoxifene, bazedoxifene and arzoxifene, are expected to demonstrate antifracture efficacy at the hip level, whilst retaining the extra-skeletal benefits (such as in the breast) that are obtained with raloxifene. The peptides from the parathyroid hormone family are potent stimulators of bone formation. Teriparatide (1 - 34 amino acid fragment of the parathyroid hormone) reduces spine and non-spine fractures, an effect that is sustained for up to 30 months after the withdrawal of treatment. The intact hormone (1 - 84 amino acids) showed similar results on spine fractures, and more data are requested to evaluate its effect on non-spine or hip fractures. Strontium ranelate is suggested to be the first medication to uncouple bone formation from bone resorption. It has shown antifracture efficacy at all sites in a large number of postmenopausal women. New developments include: denosumab, an antibody against receptor activator of NF-kappaB ligand (RANKL); a cytokine that is responsible for osteoclastogenesis; and inhibitors of cathepsin K, a cysteine protease that is involved in the cleavage of collagen.

Authors+Show Affiliations

Department of Public Health, Epidemiology and Health Economics, CHU Sart Tilman, University of Liège, Liège--Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16872263

Citation

Close, Pierre, et al. "Developments in the Pharmacotherapeutic Management of Osteoporosis." Expert Opinion On Pharmacotherapy, vol. 7, no. 12, 2006, pp. 1603-15.
Close P, Neuprez A, Reginster JY. Developments in the pharmacotherapeutic management of osteoporosis. Expert Opin Pharmacother. 2006;7(12):1603-15.
Close, P., Neuprez, A., & Reginster, J. Y. (2006). Developments in the pharmacotherapeutic management of osteoporosis. Expert Opinion On Pharmacotherapy, 7(12), 1603-15.
Close P, Neuprez A, Reginster JY. Developments in the Pharmacotherapeutic Management of Osteoporosis. Expert Opin Pharmacother. 2006;7(12):1603-15. PubMed PMID: 16872263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developments in the pharmacotherapeutic management of osteoporosis. AU - Close,Pierre, AU - Neuprez,Audrey, AU - Reginster,Jean-Yves, PY - 2006/7/29/pubmed PY - 2006/8/19/medline PY - 2006/7/29/entrez SP - 1603 EP - 15 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 7 IS - 12 N2 - During the last two decades, several medications have been granted a marketing authorisation for the management of osteoporosis. Bisphosphonates are the most widely prescribed drugs in this area, worldwide. Alendronate and risedronate are given daily or weekly and have demonstrated their ability to reduce fracture rates at the spine and hip. Ibandronate has demonstrated spine antifracture efficacy with intervals between dosings greater than weekly. New developments in this class include intravenous administration of ibandronate or zoledronate, once every three months or once yearly. Raloxifene, a selective estrogen-receptor modulator, reduces spine fractures and, in post-hoc analyses, non-spine fractures in high-risk subjects. New selective estrogen-receptor modulators, including lasofoxifene, bazedoxifene and arzoxifene, are expected to demonstrate antifracture efficacy at the hip level, whilst retaining the extra-skeletal benefits (such as in the breast) that are obtained with raloxifene. The peptides from the parathyroid hormone family are potent stimulators of bone formation. Teriparatide (1 - 34 amino acid fragment of the parathyroid hormone) reduces spine and non-spine fractures, an effect that is sustained for up to 30 months after the withdrawal of treatment. The intact hormone (1 - 84 amino acids) showed similar results on spine fractures, and more data are requested to evaluate its effect on non-spine or hip fractures. Strontium ranelate is suggested to be the first medication to uncouple bone formation from bone resorption. It has shown antifracture efficacy at all sites in a large number of postmenopausal women. New developments include: denosumab, an antibody against receptor activator of NF-kappaB ligand (RANKL); a cytokine that is responsible for osteoclastogenesis; and inhibitors of cathepsin K, a cysteine protease that is involved in the cleavage of collagen. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/16872263/Developments_in_the_pharmacotherapeutic_management_of_osteoporosis_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656566.7.12.1603 DB - PRIME DP - Unbound Medicine ER -