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UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism.
Biochim Biophys Acta. 2006 Sep-Oct; 1757(9-10):1284-91.BB

Abstract

Uncoupling proteins (UCPs) are specialized members of the mitochondrial transporter family. They allow passive proton transport through the mitochondrial inner membrane. This activity leads to uncoupling of mitochondrial respiration and to energy waste, which is well documented with UCP1 in brown adipose tissue. The uncoupling activity of the new UCPs (discovered after 1997), such as UCP2 and UCP3 in mammals or avUCP in birds, is more difficult to characterize. However, extensive data support the idea that the new UCPs are involved in the control of reactive oxygen species (ROS) generation. This fits with the hypothesis that mild uncoupling caused by the UCPs prevents ROS production. Activators and inhibitors regulate the proton transport activity of the UCPs. In the absence of activators of proton transport, the UCP allows the permeation of other ions. We suggest that this activity has physiological significance and, for example, UCP3 expressed in glycolytic muscle fibres may be a passive pyruvate transporter ensuring equilibrium between glycolysis and oxidative phosphorylation. Induction of UCP2 expression by glutamine strengthens the proposal that new UCPs could act to determine the choice of mitochondrial substrate. This would obviously have an impact on mitochondrial bioenergetics and ROS production.

Authors+Show Affiliations

CNRS UPR-9078, Université René Descartes Site Necker, 156 rue de Vaugirard 75730 Paris Cedex 15, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16872578

Citation

Criscuolo, François, et al. "UCP2, UCP3, avUCP, what Do They Do when Proton Transport Is Not Stimulated? Possible Relevance to Pyruvate and Glutamine Metabolism." Biochimica Et Biophysica Acta, vol. 1757, no. 9-10, 2006, pp. 1284-91.
Criscuolo F, Mozo J, Hurtaud C, et al. UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism. Biochim Biophys Acta. 2006;1757(9-10):1284-91.
Criscuolo, F., Mozo, J., Hurtaud, C., Nübel, T., & Bouillaud, F. (2006). UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism. Biochimica Et Biophysica Acta, 1757(9-10), 1284-91.
Criscuolo F, et al. UCP2, UCP3, avUCP, what Do They Do when Proton Transport Is Not Stimulated? Possible Relevance to Pyruvate and Glutamine Metabolism. Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1284-91. PubMed PMID: 16872578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism. AU - Criscuolo,François, AU - Mozo,Julien, AU - Hurtaud,Corinne, AU - Nübel,Tobias, AU - Bouillaud,Frédéric, Y1 - 2006/06/17/ PY - 2006/01/30/received PY - 2006/05/30/revised PY - 2006/06/08/accepted PY - 2006/7/29/pubmed PY - 2006/12/9/medline PY - 2006/7/29/entrez SP - 1284 EP - 91 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1757 IS - 9-10 N2 - Uncoupling proteins (UCPs) are specialized members of the mitochondrial transporter family. They allow passive proton transport through the mitochondrial inner membrane. This activity leads to uncoupling of mitochondrial respiration and to energy waste, which is well documented with UCP1 in brown adipose tissue. The uncoupling activity of the new UCPs (discovered after 1997), such as UCP2 and UCP3 in mammals or avUCP in birds, is more difficult to characterize. However, extensive data support the idea that the new UCPs are involved in the control of reactive oxygen species (ROS) generation. This fits with the hypothesis that mild uncoupling caused by the UCPs prevents ROS production. Activators and inhibitors regulate the proton transport activity of the UCPs. In the absence of activators of proton transport, the UCP allows the permeation of other ions. We suggest that this activity has physiological significance and, for example, UCP3 expressed in glycolytic muscle fibres may be a passive pyruvate transporter ensuring equilibrium between glycolysis and oxidative phosphorylation. Induction of UCP2 expression by glutamine strengthens the proposal that new UCPs could act to determine the choice of mitochondrial substrate. This would obviously have an impact on mitochondrial bioenergetics and ROS production. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/16872578/UCP2_UCP3_avUCP_what_do_they_do_when_proton_transport_is_not_stimulated_Possible_relevance_to_pyruvate_and_glutamine_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0005-2728(06)00183-6 DB - PRIME DP - Unbound Medicine ER -