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[Uncertain effects of folic acid on disorders other than neural-tube defects].
Ned Tijdschr Geneeskd. 2006 Jul 01; 150(26):1439-42.NT

Abstract

Periconceptional supplemention with folic acid prevents neural-tube defects in infants. However, contrary to expectations, clinical trials found no beneficial effect of folic acid on the recurrence of cardiovascular disease. Trial evidence on folic acid and cognitive decline or dementia is scarce, though observational studies suggest that high folate intake may prevent these disorders. In contrast, animal studies suggest that high doses of folic acid enhance the growth of existing tumours. However, recent clinical trials failed to show significant effects of folic acid on cancer incidence and mortality. There are also speculations that folic-acid fortification may increase the number of newborns with the thermolabile variant of methylene tetrahydrofolate reductase. There appears to be little evidence that folic-acid supplementation may mask vitamin-B12 deficiency. In view of these controversies, it is unlikely that The Netherlands will mandate folic-acid fortification of staple foods in the near future. Therefore, women who are planning a pregnancy should be urged to take folic-acid supplements.

Authors+Show Affiliations

Wageningen Centre for Food Sciences en Wageningen Universiteit, afd. Humane Voeding, Bomenweg 2, 6703 HD Wageningen. petra.verhoef@wur.nlNo affiliation info available

Pub Type(s)

Comment
English Abstract
Journal Article

Language

dut

PubMed ID

16875263

Citation

Verhoef, P, and M B. Katan. "[Uncertain Effects of Folic Acid On Disorders Other Than Neural-tube Defects]." Nederlands Tijdschrift Voor Geneeskunde, vol. 150, no. 26, 2006, pp. 1439-42.
Verhoef P, Katan MB. [Uncertain effects of folic acid on disorders other than neural-tube defects]. Ned Tijdschr Geneeskd. 2006;150(26):1439-42.
Verhoef, P., & Katan, M. B. (2006). [Uncertain effects of folic acid on disorders other than neural-tube defects]. Nederlands Tijdschrift Voor Geneeskunde, 150(26), 1439-42.
Verhoef P, Katan MB. [Uncertain Effects of Folic Acid On Disorders Other Than Neural-tube Defects]. Ned Tijdschr Geneeskd. 2006 Jul 1;150(26):1439-42. PubMed PMID: 16875263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Uncertain effects of folic acid on disorders other than neural-tube defects]. AU - Verhoef,P, AU - Katan,M B, PY - 2006/8/1/pubmed PY - 2006/8/30/medline PY - 2006/8/1/entrez SP - 1439 EP - 42 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 150 IS - 26 N2 - Periconceptional supplemention with folic acid prevents neural-tube defects in infants. However, contrary to expectations, clinical trials found no beneficial effect of folic acid on the recurrence of cardiovascular disease. Trial evidence on folic acid and cognitive decline or dementia is scarce, though observational studies suggest that high folate intake may prevent these disorders. In contrast, animal studies suggest that high doses of folic acid enhance the growth of existing tumours. However, recent clinical trials failed to show significant effects of folic acid on cancer incidence and mortality. There are also speculations that folic-acid fortification may increase the number of newborns with the thermolabile variant of methylene tetrahydrofolate reductase. There appears to be little evidence that folic-acid supplementation may mask vitamin-B12 deficiency. In view of these controversies, it is unlikely that The Netherlands will mandate folic-acid fortification of staple foods in the near future. Therefore, women who are planning a pregnancy should be urged to take folic-acid supplements. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/16875263/[Uncertain_effects_of_folic_acid_on_disorders_other_than_neural_tube_defects]_ L2 - http://www.diseaseinfosearch.org/result/8992 DB - PRIME DP - Unbound Medicine ER -