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[Folic acid fortification: prevention as well as promotion of cancer].
Ned Tijdschr Geneeskd. 2006 Jul 01; 150(26):1443-8.NT

Abstract

In many countries foods are fortified with folic acid to prevent neural-tube defects. Beneficial effects on cancer, cardiovascular diseases and dementia are also assumed. Fortification with folic acid is not allowed in The Netherlands, although exemption can be granted. As well as beneficial effects, harmful effects may also occur. In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans. In addition, it has been hypothesized that fortification with folic acid may have further negative effects on cancer through genetic selection. Given the high prevalence of cancer, these potentially harmful effects should also be taken into account in the Dutch debate on the advantages and disadvantages of folic acid fortification.

Authors+Show Affiliations

Rijksinstituut voor Volksgezondheid en Milieu, Postbus 1, 3720 BA Bilthoven. janneke.kloosterman@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

16875264

Citation

Kloosterman, J, et al. "[Folic Acid Fortification: Prevention as Well as Promotion of Cancer]." Nederlands Tijdschrift Voor Geneeskunde, vol. 150, no. 26, 2006, pp. 1443-8.
Kloosterman J, de Jong N, Rompelberg CJ, et al. [Folic acid fortification: prevention as well as promotion of cancer]. Ned Tijdschr Geneeskd. 2006;150(26):1443-8.
Kloosterman, J., de Jong, N., Rompelberg, C. J., van Kranen, H. J., Kampman, E., & Ocké, M. C. (2006). [Folic acid fortification: prevention as well as promotion of cancer]. Nederlands Tijdschrift Voor Geneeskunde, 150(26), 1443-8.
Kloosterman J, et al. [Folic Acid Fortification: Prevention as Well as Promotion of Cancer]. Ned Tijdschr Geneeskd. 2006 Jul 1;150(26):1443-8. PubMed PMID: 16875264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Folic acid fortification: prevention as well as promotion of cancer]. AU - Kloosterman,J, AU - de Jong,N, AU - Rompelberg,C J M, AU - van Kranen,H J, AU - Kampman,E, AU - Ocké,M C, PY - 2006/8/1/pubmed PY - 2006/8/30/medline PY - 2006/8/1/entrez SP - 1443 EP - 8 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 150 IS - 26 N2 - In many countries foods are fortified with folic acid to prevent neural-tube defects. Beneficial effects on cancer, cardiovascular diseases and dementia are also assumed. Fortification with folic acid is not allowed in The Netherlands, although exemption can be granted. As well as beneficial effects, harmful effects may also occur. In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans. In addition, it has been hypothesized that fortification with folic acid may have further negative effects on cancer through genetic selection. Given the high prevalence of cancer, these potentially harmful effects should also be taken into account in the Dutch debate on the advantages and disadvantages of folic acid fortification. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/16875264/[Folic_acid_fortification:_prevention_as_well_as_promotion_of_cancer]_ L2 - https://medlineplus.gov/folicacid.html DB - PRIME DP - Unbound Medicine ER -