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Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans.
J Am Coll Cardiol 2006; 48(3):478-84JACC

Abstract

OBJECTIVES

We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk.

BACKGROUND

Fish consumption may reduce the incidence of sudden death and atrial fibrillation, possibly related to anti-arrhythmic effects.

METHODS

In a population-based study of 5,096 men and women, we evaluated cross-sectional associations between usual dietary fish intake and electrocardiographic measures of heart rate, atrioventricular conduction (PR interval), ventricular repolarization (QT interval), and ventricular conduction (QRS interval). Multivariate models were adjusted for age, gender, race, education, smoking, body mass index, diabetes, coronary heart disease, physical activity, and intakes of beef or pork, fried fish, fruits, vegetables, alcohol, and total calories.

RESULTS

Consumption of tuna or other broiled or baked fish (comparing the highest to the lowest category of intake) was associated with lower heart rate (-3.2 beats/min, 95% confidence interval [CI] = 1.3 to 5.1; p trend <0.001), slower atrioventricular conduction (PR interval +7.2 ms, 95% CI = 1.4 to 12.9; p trend = 0.03), and substantially lower likelihood of prolonged QT (relative risk = 0.50, 95% CI = 0.27 to 0.95; p trend = 0.03). Tuna/other fish intake was not associated with ventricular conduction (p = 0.60). Findings were similar for estimated intake of marine n-3 fatty acids: a 1 g/day higher intake was associated with 2.3 beats/min lower heart rate (95% CI = 0.9 to 3.7), 7.6 ms longer PR interval (95% CI = 3.3 to 11.9), and 46% lower likelihood of prolonged QT (relative risk = 0.54, 95% CI = 0.33 to 0.88).

CONCLUSIONS

These findings in this large, population-based study suggest that dietary fish intake is associated with cardiac electrophysiology in humans, including heart rate, atrioventricular conduction, and ventricular repolarization, with potential implications for arrhythmic risk.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. dmozaffa@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16875972

Citation

Mozaffarian, Dariush, et al. "Dietary Fish and N-3 Fatty Acid Intake and Cardiac Electrocardiographic Parameters in Humans." Journal of the American College of Cardiology, vol. 48, no. 3, 2006, pp. 478-84.
Mozaffarian D, Prineas RJ, Stein PK, et al. Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. J Am Coll Cardiol. 2006;48(3):478-84.
Mozaffarian, D., Prineas, R. J., Stein, P. K., & Siscovick, D. S. (2006). Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. Journal of the American College of Cardiology, 48(3), pp. 478-84.
Mozaffarian D, et al. Dietary Fish and N-3 Fatty Acid Intake and Cardiac Electrocardiographic Parameters in Humans. J Am Coll Cardiol. 2006 Aug 1;48(3):478-84. PubMed PMID: 16875972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. AU - Mozaffarian,Dariush, AU - Prineas,Ronald J, AU - Stein,Phyllis K, AU - Siscovick,David S, Y1 - 2006/07/12/ PY - 2006/01/12/received PY - 2006/03/17/revised PY - 2006/03/22/accepted PY - 2006/8/1/pubmed PY - 2006/8/17/medline PY - 2006/8/1/entrez SP - 478 EP - 84 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 48 IS - 3 N2 - OBJECTIVES: We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk. BACKGROUND: Fish consumption may reduce the incidence of sudden death and atrial fibrillation, possibly related to anti-arrhythmic effects. METHODS: In a population-based study of 5,096 men and women, we evaluated cross-sectional associations between usual dietary fish intake and electrocardiographic measures of heart rate, atrioventricular conduction (PR interval), ventricular repolarization (QT interval), and ventricular conduction (QRS interval). Multivariate models were adjusted for age, gender, race, education, smoking, body mass index, diabetes, coronary heart disease, physical activity, and intakes of beef or pork, fried fish, fruits, vegetables, alcohol, and total calories. RESULTS: Consumption of tuna or other broiled or baked fish (comparing the highest to the lowest category of intake) was associated with lower heart rate (-3.2 beats/min, 95% confidence interval [CI] = 1.3 to 5.1; p trend <0.001), slower atrioventricular conduction (PR interval +7.2 ms, 95% CI = 1.4 to 12.9; p trend = 0.03), and substantially lower likelihood of prolonged QT (relative risk = 0.50, 95% CI = 0.27 to 0.95; p trend = 0.03). Tuna/other fish intake was not associated with ventricular conduction (p = 0.60). Findings were similar for estimated intake of marine n-3 fatty acids: a 1 g/day higher intake was associated with 2.3 beats/min lower heart rate (95% CI = 0.9 to 3.7), 7.6 ms longer PR interval (95% CI = 3.3 to 11.9), and 46% lower likelihood of prolonged QT (relative risk = 0.54, 95% CI = 0.33 to 0.88). CONCLUSIONS: These findings in this large, population-based study suggest that dietary fish intake is associated with cardiac electrophysiology in humans, including heart rate, atrioventricular conduction, and ventricular repolarization, with potential implications for arrhythmic risk. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/16875972/Dietary_fish_and_n_3_fatty_acid_intake_and_cardiac_electrocardiographic_parameters_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(06)01254-X DB - PRIME DP - Unbound Medicine ER -