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Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood.
Biol Psychiatry. 2007 Feb 15; 61(4):554-63.BP

Abstract

BACKGROUND

Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing.

METHODS

We used an animal model to study the effects of prenatal exposure to Delta(9)-tetrahydrocannabinol (THC) on heroin self-administration behavior and opioid neural systems in adult males (postnatal day 62). Rats were exposed to THC (.15 mg/kg) or vehicle from gestational day 5 to postnatal day 2.

RESULTS

Both pretreatment groups showed similar heroin intake, but THC-exposed rats exhibited shorter latency to the first active lever press, responded more for low heroin doses, and had higher heroin-seeking during mild stress and drug extinction. THC exposure reduced preproenkephalin (PENK) mRNA expression in the nucleus accumbens during early development, but was elevated in adulthood; no adult striatal changes on preprodynorphin mRNA or PENK in caudate-putamen. PENK mRNA was also increased in the central and medial amygdala in adult THC-exposed animals. THC animals had reduced heroin-induced locomotor activity and nucleus accumbens mu opioid receptor coupling.

CONCLUSIONS

This study demonstrates enduring effects of prenatal THC exposure into adulthood that is evident on heroin-seeking behavior during extinction and allostatic changes in mesocorticolimbic PENK systems relevant to drug motivation/reward and stress response.

Authors+Show Affiliations

Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, S-17176 Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16876136

Citation

Spano, M Sabrina, et al. "Prenatal Cannabis Exposure Increases Heroin Seeking With Allostatic Changes in Limbic Enkephalin Systems in Adulthood." Biological Psychiatry, vol. 61, no. 4, 2007, pp. 554-63.
Spano MS, Ellgren M, Wang X, et al. Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood. Biol Psychiatry. 2007;61(4):554-63.
Spano, M. S., Ellgren, M., Wang, X., & Hurd, Y. L. (2007). Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood. Biological Psychiatry, 61(4), 554-63.
Spano MS, et al. Prenatal Cannabis Exposure Increases Heroin Seeking With Allostatic Changes in Limbic Enkephalin Systems in Adulthood. Biol Psychiatry. 2007 Feb 15;61(4):554-63. PubMed PMID: 16876136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood. AU - Spano,M Sabrina, AU - Ellgren,Maria, AU - Wang,X, AU - Hurd,Yasmin L, Y1 - 2006/07/28/ PY - 2005/09/09/received PY - 2006/01/19/revised PY - 2006/03/22/accepted PY - 2006/8/1/pubmed PY - 2007/3/28/medline PY - 2006/8/1/entrez SP - 554 EP - 63 JF - Biological psychiatry JO - Biol Psychiatry VL - 61 IS - 4 N2 - BACKGROUND: Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing. METHODS: We used an animal model to study the effects of prenatal exposure to Delta(9)-tetrahydrocannabinol (THC) on heroin self-administration behavior and opioid neural systems in adult males (postnatal day 62). Rats were exposed to THC (.15 mg/kg) or vehicle from gestational day 5 to postnatal day 2. RESULTS: Both pretreatment groups showed similar heroin intake, but THC-exposed rats exhibited shorter latency to the first active lever press, responded more for low heroin doses, and had higher heroin-seeking during mild stress and drug extinction. THC exposure reduced preproenkephalin (PENK) mRNA expression in the nucleus accumbens during early development, but was elevated in adulthood; no adult striatal changes on preprodynorphin mRNA or PENK in caudate-putamen. PENK mRNA was also increased in the central and medial amygdala in adult THC-exposed animals. THC animals had reduced heroin-induced locomotor activity and nucleus accumbens mu opioid receptor coupling. CONCLUSIONS: This study demonstrates enduring effects of prenatal THC exposure into adulthood that is evident on heroin-seeking behavior during extinction and allostatic changes in mesocorticolimbic PENK systems relevant to drug motivation/reward and stress response. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16876136/Prenatal_cannabis_exposure_increases_heroin_seeking_with_allostatic_changes_in_limbic_enkephalin_systems_in_adulthood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)00557-9 DB - PRIME DP - Unbound Medicine ER -