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Frequency of optic disk hemorrhages in adult chinese in rural and urban china: the Beijing eye study.
Am J Ophthalmol 2006; 142(2):241-6AJ

Abstract

PURPOSE

To determine the frequency of optic disk hemorrhages in the adult Chinese population.

DESIGN

Population-based prevalence survey.

METHODS

The study included 4439 subjects out of 5324 subjects invited to participate (response rate 83.4%) with an age of 40+ years. Mean age was 56.2 +/- 10.6 years. Color optic disk photographs (45 degrees) were morphometrically examined.

RESULTS

Optic disk photographs were available for 8655 eyes of 4378/4439 (98.6%) subjects. Prevalence of disk hemorrhages was 107/8655 (1.24%; 95% confidence interval (CI): 1.00%, 1.47%) eyes. Occurrence of disk hemorrhages was significantly associated with glaucomatous optic nerve damage (P < .001; OR: 9.3; 95% CI: 5.6, 15.4) and age (P = .008; 95% CI: 1.01, 1.05). The occurrence of disk hemorrhages was not significantly associated with intraocular pressure (IOP) (P = .63; 95% CI: 0.97, 1.06), refractive error (P = .06; 5% CI: 0.87, 2.18), and visual field score (P = .81; 95% CI: 0.96, 1.03). Defining glaucoma as glaucomatous optic disk appearance, 20/107 (18.7%; 95% CI: 11.2%, 26.2%) disk hemorrhages were found in glaucomatous eyes. Out of 226 glaucomatous eyes, 20/226 (8.8%; 95%CI: 5.12%, 12.58%) eyes showed a disk hemorrhage. Hypertensive glaucoma eyes and normotensive glaucoma eyes did not vary considerably in frequency of disk hemorrhages (P = .44; OR: 1.82; 95% CI: 0.59, 5.68).

CONCLUSIONS

Disk hemorrhages occur in a frequency of approximately 1.2% in adult Chinese. Major associated factors are glaucomatous optic neuropathy and age. Presence of a disk hemorrhage suggested glaucomatous optic nerve damage with a positive predictive value of approximately 20%. About 9% of glaucomatous eyes showed a disk hemorrhage at the time of examination.

Authors+Show Affiliations

Beijing Institute of Ophthalmology, Beijing Tongren Hospital and Capital University of Medical Science, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16876503

Citation

Wang, Yun, et al. "Frequency of Optic Disk Hemorrhages in Adult Chinese in Rural and Urban China: the Beijing Eye Study." American Journal of Ophthalmology, vol. 142, no. 2, 2006, pp. 241-6.
Wang Y, Xu L, Hu L, et al. Frequency of optic disk hemorrhages in adult chinese in rural and urban china: the Beijing eye study. Am J Ophthalmol. 2006;142(2):241-6.
Wang, Y., Xu, L., Hu, L., Wang, Y., Yang, H., & Jonas, J. B. (2006). Frequency of optic disk hemorrhages in adult chinese in rural and urban china: the Beijing eye study. American Journal of Ophthalmology, 142(2), pp. 241-6.
Wang Y, et al. Frequency of Optic Disk Hemorrhages in Adult Chinese in Rural and Urban China: the Beijing Eye Study. Am J Ophthalmol. 2006;142(2):241-6. PubMed PMID: 16876503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of optic disk hemorrhages in adult chinese in rural and urban china: the Beijing eye study. AU - Wang,Yun, AU - Xu,Liang, AU - Hu,Lianna, AU - Wang,Yaxing, AU - Yang,Hua, AU - Jonas,Jost B, PY - 2006/01/19/received PY - 2006/02/27/revised PY - 2006/02/27/accepted PY - 2006/8/1/pubmed PY - 2006/8/30/medline PY - 2006/8/1/entrez SP - 241 EP - 6 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 142 IS - 2 N2 - PURPOSE: To determine the frequency of optic disk hemorrhages in the adult Chinese population. DESIGN: Population-based prevalence survey. METHODS: The study included 4439 subjects out of 5324 subjects invited to participate (response rate 83.4%) with an age of 40+ years. Mean age was 56.2 +/- 10.6 years. Color optic disk photographs (45 degrees) were morphometrically examined. RESULTS: Optic disk photographs were available for 8655 eyes of 4378/4439 (98.6%) subjects. Prevalence of disk hemorrhages was 107/8655 (1.24%; 95% confidence interval (CI): 1.00%, 1.47%) eyes. Occurrence of disk hemorrhages was significantly associated with glaucomatous optic nerve damage (P < .001; OR: 9.3; 95% CI: 5.6, 15.4) and age (P = .008; 95% CI: 1.01, 1.05). The occurrence of disk hemorrhages was not significantly associated with intraocular pressure (IOP) (P = .63; 95% CI: 0.97, 1.06), refractive error (P = .06; 5% CI: 0.87, 2.18), and visual field score (P = .81; 95% CI: 0.96, 1.03). Defining glaucoma as glaucomatous optic disk appearance, 20/107 (18.7%; 95% CI: 11.2%, 26.2%) disk hemorrhages were found in glaucomatous eyes. Out of 226 glaucomatous eyes, 20/226 (8.8%; 95%CI: 5.12%, 12.58%) eyes showed a disk hemorrhage. Hypertensive glaucoma eyes and normotensive glaucoma eyes did not vary considerably in frequency of disk hemorrhages (P = .44; OR: 1.82; 95% CI: 0.59, 5.68). CONCLUSIONS: Disk hemorrhages occur in a frequency of approximately 1.2% in adult Chinese. Major associated factors are glaucomatous optic neuropathy and age. Presence of a disk hemorrhage suggested glaucomatous optic nerve damage with a positive predictive value of approximately 20%. About 9% of glaucomatous eyes showed a disk hemorrhage at the time of examination. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/16876503/Frequency_of_optic_disk_hemorrhages_in_adult_chinese_in_rural_and_urban_china:_the_Beijing_eye_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(06)00327-8 DB - PRIME DP - Unbound Medicine ER -