Tags

Type your tag names separated by a space and hit enter

Retinal vascular abnormalities in adult Chinese in rural and urban Beijing: the Beijing Eye Study.
Ophthalmology 2006; 113(10):1752-7O

Abstract

OBJECTIVE

To assess retinal vascular abnormalities, including focal and generalized arteriolar narrowing, arteriovenous nicking, and arteriolar sheathing, in adult Chinese in rural and urban Beijing, and their associations with self-reported diagnosis of cardiovascular and cerebrovascular diseases.

DESIGN

Population-based cross-sectional cohort study.

PARTICIPANTS

The study included 4439 subjects out of 5324 subjects invited to participate (response rate, 83.4%) with an age of > or =40 years. It was divided into a rural part (n = 1973 [44.4%]) and an urban part (n = 2466 [55.6%]). Mean age was 56.2+/-10.6 years (range, 40-101 years).

METHODS

Color optic disc photographs were morphometrically examined. One eye of each participant was randomly selected. Generalized and focal arteriolar narrowing, arteriovenous nicking (arteriovenous crossing abnormalities), and arteriolar sheathing were assessed. Self-reported histories of cardiovascular and cerebrovascular diseases and habits of smoking and alcohol drinking were obtained from questionnaires.

MAIN OUTCOME MEASURES

Frequency of generalized and focal arteriolar narrowing, arteriovenous nicking, and arteriolar sheathing.

RESULTS

Optic disc photographs were available for 4228 (95.2%) subjects. Focal arteriolar narrowing was found in 6.3%, arteriovenous nicking in 6.6%, arteriolar sheathing in 4.8%, and generalized narrowing in 4.3% of the subjects. Abnormalities were more common in the temporal quadrant; they were rare in the inferior nasal quadrant. Frequencies and severities of all retinal microvascular abnormalities examined increased with age (P<0.05). The microvascular abnormalities were detected more frequently in the rural population than in the urban population (P<0.05). After controlling for age, gender, area, and habit of drinking alcohol, generalized arteriolar narrowing (odds ratio [OR], 2.63; 95% confidence interval [CI], 1.64, 4.22), focal arteriolar narrowing (OR, 1.51; 95% CI, 1.00, 2.29), and arteriolar sheathing (OR, 1.71; 95% CI, 1.08, 2.71) were significantly associated with the self-reported diagnosis of arterial hypertension. The microvascular abnormalities were not significantly associated with the self-reported diagnosis of coronary heart disease or stroke.

CONCLUSIONS

Retinal vascular abnormalities in adult Chinese increase with age and are more commonly found in people living in rural areas. Retinal vascular abnormalities are associated with the self-reported diagnosis of arterial hypertension, and are not related to self-reported diagnosis of coronary heart disease or previous cerebrovascular events such as stroke.

Authors+Show Affiliations

Beijing Institute of Ophthalmology, Beijing Tongren Hospital and Capital University of Medical Science, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16876866

Citation

Wang, Shuang, et al. "Retinal Vascular Abnormalities in Adult Chinese in Rural and Urban Beijing: the Beijing Eye Study." Ophthalmology, vol. 113, no. 10, 2006, pp. 1752-7.
Wang S, Xu L, Jonas JB, et al. Retinal vascular abnormalities in adult Chinese in rural and urban Beijing: the Beijing Eye Study. Ophthalmology. 2006;113(10):1752-7.
Wang, S., Xu, L., Jonas, J. B., Wang, Y. S., Wang, Y., Yang, H., & Li, J. (2006). Retinal vascular abnormalities in adult Chinese in rural and urban Beijing: the Beijing Eye Study. Ophthalmology, 113(10), pp. 1752-7.
Wang S, et al. Retinal Vascular Abnormalities in Adult Chinese in Rural and Urban Beijing: the Beijing Eye Study. Ophthalmology. 2006;113(10):1752-7. PubMed PMID: 16876866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vascular abnormalities in adult Chinese in rural and urban Beijing: the Beijing Eye Study. AU - Wang,Shuang, AU - Xu,Liang, AU - Jonas,Jost B, AU - Wang,Yun Song, AU - Wang,Yaxing, AU - Yang,Hua, AU - Li,Jing, Y1 - 2006/07/31/ PY - 2005/11/15/received PY - 2006/05/15/revised PY - 2006/05/16/accepted PY - 2006/8/1/pubmed PY - 2006/10/14/medline PY - 2006/8/1/entrez SP - 1752 EP - 7 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 10 N2 - OBJECTIVE: To assess retinal vascular abnormalities, including focal and generalized arteriolar narrowing, arteriovenous nicking, and arteriolar sheathing, in adult Chinese in rural and urban Beijing, and their associations with self-reported diagnosis of cardiovascular and cerebrovascular diseases. DESIGN: Population-based cross-sectional cohort study. PARTICIPANTS: The study included 4439 subjects out of 5324 subjects invited to participate (response rate, 83.4%) with an age of > or =40 years. It was divided into a rural part (n = 1973 [44.4%]) and an urban part (n = 2466 [55.6%]). Mean age was 56.2+/-10.6 years (range, 40-101 years). METHODS: Color optic disc photographs were morphometrically examined. One eye of each participant was randomly selected. Generalized and focal arteriolar narrowing, arteriovenous nicking (arteriovenous crossing abnormalities), and arteriolar sheathing were assessed. Self-reported histories of cardiovascular and cerebrovascular diseases and habits of smoking and alcohol drinking were obtained from questionnaires. MAIN OUTCOME MEASURES: Frequency of generalized and focal arteriolar narrowing, arteriovenous nicking, and arteriolar sheathing. RESULTS: Optic disc photographs were available for 4228 (95.2%) subjects. Focal arteriolar narrowing was found in 6.3%, arteriovenous nicking in 6.6%, arteriolar sheathing in 4.8%, and generalized narrowing in 4.3% of the subjects. Abnormalities were more common in the temporal quadrant; they were rare in the inferior nasal quadrant. Frequencies and severities of all retinal microvascular abnormalities examined increased with age (P<0.05). The microvascular abnormalities were detected more frequently in the rural population than in the urban population (P<0.05). After controlling for age, gender, area, and habit of drinking alcohol, generalized arteriolar narrowing (odds ratio [OR], 2.63; 95% confidence interval [CI], 1.64, 4.22), focal arteriolar narrowing (OR, 1.51; 95% CI, 1.00, 2.29), and arteriolar sheathing (OR, 1.71; 95% CI, 1.08, 2.71) were significantly associated with the self-reported diagnosis of arterial hypertension. The microvascular abnormalities were not significantly associated with the self-reported diagnosis of coronary heart disease or stroke. CONCLUSIONS: Retinal vascular abnormalities in adult Chinese increase with age and are more commonly found in people living in rural areas. Retinal vascular abnormalities are associated with the self-reported diagnosis of arterial hypertension, and are not related to self-reported diagnosis of coronary heart disease or previous cerebrovascular events such as stroke. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16876866/Retinal_vascular_abnormalities_in_adult_Chinese_in_rural_and_urban_Beijing:_the_Beijing_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00686-5 DB - PRIME DP - Unbound Medicine ER -