Tags

Type your tag names separated by a space and hit enter

Marker rhythmometry with macrophage-colony stimulating factor (M-CSF).
Chronobiologia. 1991 Oct-Dec; 18(4):141-52.C

Abstract

In a patient with a debulked müllerian adenocarcinoma involving the ovary, an elevated serum concentration of macrophage-colony stimulating factor (M-CSF) (5.3 ng/ml) was lowered into the range of the age- and gender-matched controls by a 24-hour infusion of 135 mg/m2 of taxol, as was a Ca125 of 1480 U/ml by three such taxol courses given at 3-week intervals (to 14 U/ml). A downward trend of M-CSF in serum with an about-14-hour ultradian modulation during the first chemotherapy course resembles that of the concomitantly assessed Ca125. A decreasing trend modulated by an about-half-weekly component is found in M-CSF of fractionated urines collected at spontaneous voidings around the clock for 5 days. M-CSF may serve as a chronobiologic marker for optimizing, on an individualized basis, 1) the infradian scheduling of chemotherapy courses and 2) the ultradian-circadian within-course time patterns. Timing based on markers of the anticancer effect aims at teh as-yet unattained transfer from rodent to human of cancer cures that were not previously feasible without chronobiologic considerations. This goal can be pursued with M-CSF as well as Ca125 and UGP as possibly complementary chronobiologic markers in a chronotherapy trial with taxol in humans.

Authors+Show Affiliations

University of Minnesota, Minneapolis.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1687728

Citation

Elg, S, et al. "Marker Rhythmometry With Macrophage-colony Stimulating Factor (M-CSF)." Chronobiologia, vol. 18, no. 4, 1991, pp. 141-52.
Elg S, Halberg E, Ramakrishnan S, et al. Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). Chronobiologia. 1991;18(4):141-52.
Elg, S., Halberg, E., Ramakrishnan, S., Cornélissen, G., Haus, E., Nicolau, G., Carson, L., Twiggs, L., Long, H. J., & Halberg, F. (1991). Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). Chronobiologia, 18(4), 141-52.
Elg S, et al. Marker Rhythmometry With Macrophage-colony Stimulating Factor (M-CSF). Chronobiologia. 1991 Oct-Dec;18(4):141-52. PubMed PMID: 1687728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marker rhythmometry with macrophage-colony stimulating factor (M-CSF). AU - Elg,S, AU - Halberg,E, AU - Ramakrishnan,S, AU - Cornélissen,G, AU - Haus,E, AU - Nicolau,G, AU - Carson,L, AU - Twiggs,L, AU - Long,H J,3rd AU - Halberg,F, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 141 EP - 52 JF - Chronobiologia JO - Chronobiologia VL - 18 IS - 4 N2 - In a patient with a debulked müllerian adenocarcinoma involving the ovary, an elevated serum concentration of macrophage-colony stimulating factor (M-CSF) (5.3 ng/ml) was lowered into the range of the age- and gender-matched controls by a 24-hour infusion of 135 mg/m2 of taxol, as was a Ca125 of 1480 U/ml by three such taxol courses given at 3-week intervals (to 14 U/ml). A downward trend of M-CSF in serum with an about-14-hour ultradian modulation during the first chemotherapy course resembles that of the concomitantly assessed Ca125. A decreasing trend modulated by an about-half-weekly component is found in M-CSF of fractionated urines collected at spontaneous voidings around the clock for 5 days. M-CSF may serve as a chronobiologic marker for optimizing, on an individualized basis, 1) the infradian scheduling of chemotherapy courses and 2) the ultradian-circadian within-course time patterns. Timing based on markers of the anticancer effect aims at teh as-yet unattained transfer from rodent to human of cancer cures that were not previously feasible without chronobiologic considerations. This goal can be pursued with M-CSF as well as Ca125 and UGP as possibly complementary chronobiologic markers in a chronotherapy trial with taxol in humans. SN - 0390-0037 UR - https://www.unboundmedicine.com/medline/citation/1687728/Marker_rhythmometry_with_macrophage_colony_stimulating_factor__M_CSF__ L2 - https://antibodies.cancer.gov/detail/CPTC-MUC16-1 DB - PRIME DP - Unbound Medicine ER -