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Effect of Nissen fundoplication on gastric motor and sensory functions.
J Pediatr Gastroenterol Nutr 2006; 43(2):185-9JP

Abstract

OBJECTIVES

Bloating, abdominal pain, and early satiety have been reported in up to 30% of patients after Nissen fundoplication. We hypothesized that these postsurgical complications in children and young adults are linked to either the effects of surgery on gastric sensation, compliance or motor function or to preexisting physiological abnormalities.

METHODS

We prospectively evaluated the effect of Nissen fundoplication on gastric sensory and motor functions in 13 children with gastroesophageal reflux. Gastric barostat and mixed meal gastric emptying studies were performed before surgery in all patients and were repeated after surgery in 8 and 9 children, respectively.

RESULTS

Thirteen patients (median age, 7 years; range, 6 months to 18 years) underwent open Nissen (n = 6) or laparoscopic Nissen fundoplication (n = 7). After fundoplication, patients had significantly higher minimal distending pressure values (10 mm Hg vs 3 mm Hg pre-Nissen, respectively; P < 0.001), reduced gastric compliance (slope values of 8.39 mm Hg vs 9.15 mm Hg, respectively, P < 0.001) and significantly higher pain scores (P < 0.001). Presurgery and postsurgery gastric emptying at 60, 90 and 120 minutes after feeding showed no significant changes.

CONCLUSIONS

After Nissen fundoplication, children with gastroesophageal reflux manifest the following: (1) reduction in gastric compliance, (2) increase in minimal gastric distending pressure, (3) exacerbation of the sensations discomfort with gastric distension and (4) no effect on gastric emptying.

Authors+Show Affiliations

Division of Gastroenterology, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, USA. mousah@pediatrics.ohio-state.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16877982

Citation

Mousa, Hayat, et al. "Effect of Nissen Fundoplication On Gastric Motor and Sensory Functions." Journal of Pediatric Gastroenterology and Nutrition, vol. 43, no. 2, 2006, pp. 185-9.
Mousa H, Caniano DA, Alhajj M, et al. Effect of Nissen fundoplication on gastric motor and sensory functions. J Pediatr Gastroenterol Nutr. 2006;43(2):185-9.
Mousa, H., Caniano, D. A., Alhajj, M., Gibson, L., Di Lorenzo, C., & Binkowitz, L. (2006). Effect of Nissen fundoplication on gastric motor and sensory functions. Journal of Pediatric Gastroenterology and Nutrition, 43(2), pp. 185-9.
Mousa H, et al. Effect of Nissen Fundoplication On Gastric Motor and Sensory Functions. J Pediatr Gastroenterol Nutr. 2006;43(2):185-9. PubMed PMID: 16877982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Nissen fundoplication on gastric motor and sensory functions. AU - Mousa,Hayat, AU - Caniano,Donna A, AU - Alhajj,Maya, AU - Gibson,Laurie, AU - Di Lorenzo,Carlo, AU - Binkowitz,Larry, PY - 2006/8/1/pubmed PY - 2006/10/17/medline PY - 2006/8/1/entrez SP - 185 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 43 IS - 2 N2 - OBJECTIVES: Bloating, abdominal pain, and early satiety have been reported in up to 30% of patients after Nissen fundoplication. We hypothesized that these postsurgical complications in children and young adults are linked to either the effects of surgery on gastric sensation, compliance or motor function or to preexisting physiological abnormalities. METHODS: We prospectively evaluated the effect of Nissen fundoplication on gastric sensory and motor functions in 13 children with gastroesophageal reflux. Gastric barostat and mixed meal gastric emptying studies were performed before surgery in all patients and were repeated after surgery in 8 and 9 children, respectively. RESULTS: Thirteen patients (median age, 7 years; range, 6 months to 18 years) underwent open Nissen (n = 6) or laparoscopic Nissen fundoplication (n = 7). After fundoplication, patients had significantly higher minimal distending pressure values (10 mm Hg vs 3 mm Hg pre-Nissen, respectively; P < 0.001), reduced gastric compliance (slope values of 8.39 mm Hg vs 9.15 mm Hg, respectively, P < 0.001) and significantly higher pain scores (P < 0.001). Presurgery and postsurgery gastric emptying at 60, 90 and 120 minutes after feeding showed no significant changes. CONCLUSIONS: After Nissen fundoplication, children with gastroesophageal reflux manifest the following: (1) reduction in gastric compliance, (2) increase in minimal gastric distending pressure, (3) exacerbation of the sensations discomfort with gastric distension and (4) no effect on gastric emptying. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/16877982/Effect_of_Nissen_fundoplication_on_gastric_motor_and_sensory_functions_ L2 - http://Insights.ovid.com/pubmed?pmid=16877982 DB - PRIME DP - Unbound Medicine ER -