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Flow-mediated vasodilatation of the brachial artery and intima-media thickness of carotid artery in never-treated subjects.
Int Angiol 2006; 25(3):274-9IA

Abstract

AIM

Data on the association between brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickness (IMT) are contrasting. The present study investigated the relationship between FMD and IMT and carotid atherosclerosis in never treated subjects.

METHODS

Seventy-seven subjects were investigated: 46 had no coronary heart disease (CHD) risk factors, 21 had only one, and 10 had more than one risk factor. IMT of the common carotid was measured by ultrasonography and FMD was evaluated according to standardized methods.

RESULTS

IMT increased with increasing number of risk factors (0.66+/-0.12, 0.69+/-0.12 and 0.8+/-0.17 mm, respectively, ANOVA P<0.05). FMD decreased with increasing number of risk factors (10.44+/-5.2, 6.52+/-7.11 and 7.35+/-4.42%, respectively, P<0.05). Endothelium-independent vasodilatation was similar in the 3 groups. IMT and FMD did not correlate neither in subjects without risk factors (r=-0.151, P=0.3), nor in those with 1 (r=-0.196, P=0.4) or with 2 or more risk factors (r=-0.387, P=0.2), while in the group as a whole the correlation was borderline significant (r=-0.217, P=0.058). Eleven subjects had carotid atherosclerosis and higher values of IMT, but not reduced FMD. In multiple regression analysis, diabetes and IMT, but not FMD, were associated with carotid atherosclerosis.

CONCLUSIONS

The present findings indicate that, in never treated subjects, FMD is not strictly associated with IMT or atherosclerosis of the carotid arteries.

Authors+Show Affiliations

Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy. irace@unicz.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16878076

Citation

Irace, C, et al. "Flow-mediated Vasodilatation of the Brachial Artery and Intima-media Thickness of Carotid Artery in Never-treated Subjects." International Angiology : a Journal of the International Union of Angiology, vol. 25, no. 3, 2006, pp. 274-9.
Irace C, Fiaschi E, Cortese C, et al. Flow-mediated vasodilatation of the brachial artery and intima-media thickness of carotid artery in never-treated subjects. Int Angiol. 2006;25(3):274-9.
Irace, C., Fiaschi, E., Cortese, C., & Gnasso, A. (2006). Flow-mediated vasodilatation of the brachial artery and intima-media thickness of carotid artery in never-treated subjects. International Angiology : a Journal of the International Union of Angiology, 25(3), pp. 274-9.
Irace C, et al. Flow-mediated Vasodilatation of the Brachial Artery and Intima-media Thickness of Carotid Artery in Never-treated Subjects. Int Angiol. 2006;25(3):274-9. PubMed PMID: 16878076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flow-mediated vasodilatation of the brachial artery and intima-media thickness of carotid artery in never-treated subjects. AU - Irace,C, AU - Fiaschi,E, AU - Cortese,C, AU - Gnasso,A, PY - 2006/8/1/pubmed PY - 2007/6/23/medline PY - 2006/8/1/entrez SP - 274 EP - 9 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 25 IS - 3 N2 - AIM: Data on the association between brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickness (IMT) are contrasting. The present study investigated the relationship between FMD and IMT and carotid atherosclerosis in never treated subjects. METHODS: Seventy-seven subjects were investigated: 46 had no coronary heart disease (CHD) risk factors, 21 had only one, and 10 had more than one risk factor. IMT of the common carotid was measured by ultrasonography and FMD was evaluated according to standardized methods. RESULTS: IMT increased with increasing number of risk factors (0.66+/-0.12, 0.69+/-0.12 and 0.8+/-0.17 mm, respectively, ANOVA P<0.05). FMD decreased with increasing number of risk factors (10.44+/-5.2, 6.52+/-7.11 and 7.35+/-4.42%, respectively, P<0.05). Endothelium-independent vasodilatation was similar in the 3 groups. IMT and FMD did not correlate neither in subjects without risk factors (r=-0.151, P=0.3), nor in those with 1 (r=-0.196, P=0.4) or with 2 or more risk factors (r=-0.387, P=0.2), while in the group as a whole the correlation was borderline significant (r=-0.217, P=0.058). Eleven subjects had carotid atherosclerosis and higher values of IMT, but not reduced FMD. In multiple regression analysis, diabetes and IMT, but not FMD, were associated with carotid atherosclerosis. CONCLUSIONS: The present findings indicate that, in never treated subjects, FMD is not strictly associated with IMT or atherosclerosis of the carotid arteries. SN - 0392-9590 UR - https://www.unboundmedicine.com/medline/citation/16878076/Flow_mediated_vasodilatation_of_the_brachial_artery_and_intima_media_thickness_of_carotid_artery_in_never_treated_subjects_ L2 - http://www.minervamedica.it/index2.t?show=R34Y2006N03A0274 DB - PRIME DP - Unbound Medicine ER -