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Cyclopeptides of Linum usitatissimum.
J Pept Sci. 2006 Sep; 12(9):569-74.JP

Abstract

Cyclolinopeptide A (CLA), a cyclic nonapeptide from linseed, possesses strong immunosuppressive and antimalarial activity along with the ability to inhibit cholate uptake into hepatocytes. The structure of the peptide was studied extensively in solution as well as in the solid state. It is postulated that both the Pro-Pro cis-amide bond and an 'edge-to-face' interaction between the aromatic rings of two adjacent Phe residues are important for biological activity. Structure-activity relationship studies of many linear and cyclic analogues of CLA suggest that the Pro-Xxx-Phe sequence and the flexibility of the peptide are important for the immunosuppressive activity.

Authors+Show Affiliations

Faculty of Chemistry, University of Wroclaw, 14 F. Joliot-Curie, 50-383 Wroclaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16878298

Citation

Picur, Bolesław, et al. "Cyclopeptides of Linum Usitatissimum." Journal of Peptide Science : an Official Publication of the European Peptide Society, vol. 12, no. 9, 2006, pp. 569-74.
Picur B, Cebrat M, Zabrocki J, et al. Cyclopeptides of Linum usitatissimum. J Pept Sci. 2006;12(9):569-74.
Picur, B., Cebrat, M., Zabrocki, J., & Siemion, I. Z. (2006). Cyclopeptides of Linum usitatissimum. Journal of Peptide Science : an Official Publication of the European Peptide Society, 12(9), 569-74.
Picur B, et al. Cyclopeptides of Linum Usitatissimum. J Pept Sci. 2006;12(9):569-74. PubMed PMID: 16878298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclopeptides of Linum usitatissimum. AU - Picur,Bolesław, AU - Cebrat,Marek, AU - Zabrocki,Janusz, AU - Siemion,Ignacy Z, PY - 2006/8/1/pubmed PY - 2006/12/9/medline PY - 2006/8/1/entrez SP - 569 EP - 74 JF - Journal of peptide science : an official publication of the European Peptide Society JO - J. Pept. Sci. VL - 12 IS - 9 N2 - Cyclolinopeptide A (CLA), a cyclic nonapeptide from linseed, possesses strong immunosuppressive and antimalarial activity along with the ability to inhibit cholate uptake into hepatocytes. The structure of the peptide was studied extensively in solution as well as in the solid state. It is postulated that both the Pro-Pro cis-amide bond and an 'edge-to-face' interaction between the aromatic rings of two adjacent Phe residues are important for biological activity. Structure-activity relationship studies of many linear and cyclic analogues of CLA suggest that the Pro-Xxx-Phe sequence and the flexibility of the peptide are important for the immunosuppressive activity. SN - 1075-2617 UR - https://www.unboundmedicine.com/medline/citation/16878298/Cyclopeptides_of_Linum_usitatissimum_ L2 - https://www.lens.org/lens/search?q=citation_id:16878298 DB - PRIME DP - Unbound Medicine ER -