[Effects of afobazole on the BDNF content in brain structures of inbred mice with different phenotypes of emotional stress reaction].Eksp Klin Farmakol. 2006 May-Jun; 69(3):3-6.EK
Changes in the BDNF content in brain structures--hippocampus, hypothalamus, striatum, and frontal cortex--were determined in mice of different emotional-stress reaction phenotypes, which were subjected to emotional stress and treated by the selective anxiolytic afobazole. The changes were different in BALB/c and C57BL/6 mice. Afobazole exhibited a significant protector action against a decrease in the brain BDNF level caused by emotional stress in BALB/c mice.