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Attention-deficit hyperactivity disorder -- bipolar comorbidity in children and adolescents.
Bipolar Disord. 2006 Aug; 8(4):373-81.BD

Abstract

OBJECTIVE

A substantial portion of juvenile bipolar disorder (BD) has a comorbid attention-deficit hyperactivity disorder (ADHD). The aim of our study was to analyze the cross-sectional and longitudinal implications of such comorbidity in children and adolescents with BD.

METHODS

Ninety-eight refereed patients (mean age 13.7 +/- 3.0 years) with a diagnosis of BD by the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version (K-SADS-PL) were followed for 6 months.

RESULTS

Thirty-seven BD patients (37.8%) presented a lifetime diagnosis of comorbid ADHD. The mean age of onset of ADHD was 3.7 +/- 1.1 years, and the mean age of onset of BD was 10.0 +/- 3.2 years. Bipolar subjects with comorbid ADHD were predominantly male, younger, and had an earlier onset of BD (8.1 +/- 2.8 versus 11.1 +/- 2.9 years). Bipolar-ADHD patients presented more frequently a chronic rather than an episodic course of BD, with an irritable rather than an elated mood. They showed higher rates of oppositional defiant disorder/conduct disorder, lower rates of panic disorder, and less frequently received antidepressant medications. Finally, ADHD comorbidity was associated with a greater psychosocial impairment.

CONCLUSIONS

ADHD comorbidity is frequent in juvenile BD and can influence age of onset, phenomenology, comorbidity, and course of BD. A timely diagnosis should improve our efforts regarding the outcome of these subjects.

Authors+Show Affiliations

IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy. gabriele.masi@inpe.unipi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16879138

Citation

Masi, Gabriele, et al. "Attention-deficit Hyperactivity Disorder -- Bipolar Comorbidity in Children and Adolescents." Bipolar Disorders, vol. 8, no. 4, 2006, pp. 373-81.
Masi G, Perugi G, Toni C, et al. Attention-deficit hyperactivity disorder -- bipolar comorbidity in children and adolescents. Bipolar Disord. 2006;8(4):373-81.
Masi, G., Perugi, G., Toni, C., Millepiedi, S., Mucci, M., Bertini, N., & Pfanner, C. (2006). Attention-deficit hyperactivity disorder -- bipolar comorbidity in children and adolescents. Bipolar Disorders, 8(4), 373-81.
Masi G, et al. Attention-deficit Hyperactivity Disorder -- Bipolar Comorbidity in Children and Adolescents. Bipolar Disord. 2006;8(4):373-81. PubMed PMID: 16879138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attention-deficit hyperactivity disorder -- bipolar comorbidity in children and adolescents. AU - Masi,Gabriele, AU - Perugi,Giulio, AU - Toni,Cristina, AU - Millepiedi,Stefania, AU - Mucci,Maria, AU - Bertini,Nicoletta, AU - Pfanner,Chiara, PY - 2006/8/2/pubmed PY - 2006/10/4/medline PY - 2006/8/2/entrez SP - 373 EP - 81 JF - Bipolar disorders JO - Bipolar Disord VL - 8 IS - 4 N2 - OBJECTIVE: A substantial portion of juvenile bipolar disorder (BD) has a comorbid attention-deficit hyperactivity disorder (ADHD). The aim of our study was to analyze the cross-sectional and longitudinal implications of such comorbidity in children and adolescents with BD. METHODS: Ninety-eight refereed patients (mean age 13.7 +/- 3.0 years) with a diagnosis of BD by the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version (K-SADS-PL) were followed for 6 months. RESULTS: Thirty-seven BD patients (37.8%) presented a lifetime diagnosis of comorbid ADHD. The mean age of onset of ADHD was 3.7 +/- 1.1 years, and the mean age of onset of BD was 10.0 +/- 3.2 years. Bipolar subjects with comorbid ADHD were predominantly male, younger, and had an earlier onset of BD (8.1 +/- 2.8 versus 11.1 +/- 2.9 years). Bipolar-ADHD patients presented more frequently a chronic rather than an episodic course of BD, with an irritable rather than an elated mood. They showed higher rates of oppositional defiant disorder/conduct disorder, lower rates of panic disorder, and less frequently received antidepressant medications. Finally, ADHD comorbidity was associated with a greater psychosocial impairment. CONCLUSIONS: ADHD comorbidity is frequent in juvenile BD and can influence age of onset, phenomenology, comorbidity, and course of BD. A timely diagnosis should improve our efforts regarding the outcome of these subjects. SN - 1398-5647 UR - https://www.unboundmedicine.com/medline/citation/16879138/Attention_deficit_hyperactivity_disorder____bipolar_comorbidity_in_children_and_adolescents_ L2 - https://doi.org/10.1111/j.1399-5618.2006.00342.x DB - PRIME DP - Unbound Medicine ER -