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Particle method for computer simulation of red blood cell motion in blood flow.
Comput Methods Programs Biomed 2006; 83(2):139-46CM

Abstract

A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape.

Authors+Show Affiliations

Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, Sendai 980-8579, Japan. tsubota@pfsl.mech.tohoku.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16879895

Citation

Tsubota, Ken-ichi, et al. "Particle Method for Computer Simulation of Red Blood Cell Motion in Blood Flow." Computer Methods and Programs in Biomedicine, vol. 83, no. 2, 2006, pp. 139-46.
Tsubota K, Wada S, Yamaguchi T. Particle method for computer simulation of red blood cell motion in blood flow. Comput Methods Programs Biomed. 2006;83(2):139-46.
Tsubota, K., Wada, S., & Yamaguchi, T. (2006). Particle method for computer simulation of red blood cell motion in blood flow. Computer Methods and Programs in Biomedicine, 83(2), pp. 139-46.
Tsubota K, Wada S, Yamaguchi T. Particle Method for Computer Simulation of Red Blood Cell Motion in Blood Flow. Comput Methods Programs Biomed. 2006;83(2):139-46. PubMed PMID: 16879895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Particle method for computer simulation of red blood cell motion in blood flow. AU - Tsubota,Ken-ichi, AU - Wada,Shigeo, AU - Yamaguchi,Takami, Y1 - 2006/07/31/ PY - 2005/12/26/received PY - 2006/05/07/revised PY - 2006/06/24/accepted PY - 2006/8/2/pubmed PY - 2007/1/5/medline PY - 2006/8/2/entrez SP - 139 EP - 46 JF - Computer methods and programs in biomedicine JO - Comput Methods Programs Biomed VL - 83 IS - 2 N2 - A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape. SN - 0169-2607 UR - https://www.unboundmedicine.com/medline/citation/16879895/Particle_method_for_computer_simulation_of_red_blood_cell_motion_in_blood_flow_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-2607(06)00138-6 DB - PRIME DP - Unbound Medicine ER -