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Mesenchymal stem cells: properties and role in clinical bone marrow transplantation.
Curr Opin Immunol. 2006 Oct; 18(5):586-91.CO

Abstract

Mesenchymal stem cells (MSCs) can be isolated from bone marrow, adipose tissue, cord blood and various fetal tissues. They have the capacity to differentiate into several tissues, including bone, cartilage, tendon, muscle and adipose, and produce growth factors and cytokines that promote hematopoietic cell expansion and differentiation. MSCs also have anti-proliferative, immunomodulatory and anti-inflammatory effects, but only evoke little immune reactivity. In vivo, MSCs prolong skin allograft survival and reverse severe acute graft-versus-host disease. Furthermore, they repair damaged tissue from kidney, heart, liver and gastrointestinal tract. Therefore, in the future, MSCs might have implications for treatment of allograft rejection, graft-versus-host disease, autoimmune inflammatory bowel disease and other disorders in which immunomodulation and tissue repair are required.

Authors+Show Affiliations

Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, F79, SE-141 86 Stockholm, Sweden. katarina.leblanc@ki.seNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16879957

Citation

Le Blanc, Katarina, and Olle Ringdén. "Mesenchymal Stem Cells: Properties and Role in Clinical Bone Marrow Transplantation." Current Opinion in Immunology, vol. 18, no. 5, 2006, pp. 586-91.
Le Blanc K, Ringdén O. Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. Curr Opin Immunol. 2006;18(5):586-91.
Le Blanc, K., & Ringdén, O. (2006). Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. Current Opinion in Immunology, 18(5), 586-91.
Le Blanc K, Ringdén O. Mesenchymal Stem Cells: Properties and Role in Clinical Bone Marrow Transplantation. Curr Opin Immunol. 2006;18(5):586-91. PubMed PMID: 16879957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. AU - Le Blanc,Katarina, AU - Ringdén,Olle, Y1 - 2006/08/01/ PY - 2006/06/07/received PY - 2006/07/17/accepted PY - 2006/8/2/pubmed PY - 2007/2/6/medline PY - 2006/8/2/entrez SP - 586 EP - 91 JF - Current opinion in immunology JO - Curr. Opin. Immunol. VL - 18 IS - 5 N2 - Mesenchymal stem cells (MSCs) can be isolated from bone marrow, adipose tissue, cord blood and various fetal tissues. They have the capacity to differentiate into several tissues, including bone, cartilage, tendon, muscle and adipose, and produce growth factors and cytokines that promote hematopoietic cell expansion and differentiation. MSCs also have anti-proliferative, immunomodulatory and anti-inflammatory effects, but only evoke little immune reactivity. In vivo, MSCs prolong skin allograft survival and reverse severe acute graft-versus-host disease. Furthermore, they repair damaged tissue from kidney, heart, liver and gastrointestinal tract. Therefore, in the future, MSCs might have implications for treatment of allograft rejection, graft-versus-host disease, autoimmune inflammatory bowel disease and other disorders in which immunomodulation and tissue repair are required. SN - 0952-7915 UR - https://www.unboundmedicine.com/medline/citation/16879957/Mesenchymal_stem_cells:_properties_and_role_in_clinical_bone_marrow_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-7915(06)00140-3 DB - PRIME DP - Unbound Medicine ER -