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Adoption of a plant-based diet by patients with recurrent prostate cancer.

Abstract

The Western diet has been associated with prostate cancer incidence as well as risk of disease progression after treatment. Conversely, plant-based diets have been associated with decreased risks. A pilot clinical trial of a 6-month dietary change and stress reduction intervention for asymptomatic, hormonally untreated patients experiencing a consistently rising PSA level, the first sign of recurrence of prostate cancer after surgery or radiation therapy, was conducted to investigate the level of intake of plant-based foods and the relationship between intake and the change in the rate of PSA rise. A pre-post design was employed in which each patient served as his own control. In this multifaceted intervention, patients and their spouses were encouraged to adopt and maintain a plant-based diet. The prestudy rate of PSA rise (from the time of posttreatment recurrence to the start of the study) was ascertained by review of patients' medical records. Dietary assessments were performed and prostate-specific antigen (PSA) levels ascertained at baseline, prior to the start of intervention, and at 3 and 6 months. Changes in numbers of servings of plant-based food groups were calculated and compared with rates of PSA rise over the corresponding time intervals. Median intake of whole grains increased from 1.7 servings/d at baseline to 6.9 and 5.0 servings/d at 3 and 6 months, respectively. Median intake of vegetables increased from 2.8 servings/d at baseline to 5.0 and 4.8 servings/d at 3 and 6 months, respectively. The rate of PSA rise decreased when comparing the prestudy period (0.059) to the period from 0 to 3 months (-0.002, P < .01) and increased slightly, though not significantly, when comparing the period from 0 to 3 months to the period from 3 to 6 months (0.029, P = .4316). These results provide preliminary evidence that adoption of a plant-based diet is possible to achieve as well as to maintain for several months in patients with recurrent prostate cancer. Changes in the rate of rise in PSA, an indicator of disease progression, were in the opposite direction as changes in the intake of plant-based food groups, raising the provocative possibility that PSA may have inversely tracked intake of these foods and suggesting that adoption of a plant-based diet may have therapeutic potential in the management of this condition.

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  • Authors+Show Affiliations

    ,

    School of Medicine, University of California, San Diego, La Jolla, California, USA.

    , , , ,

    Source

    Integrative cancer therapies 5:3 2006 Sep pg 214-23

    MeSH

    Aged
    Aged, 80 and over
    Diet, Vegetarian
    Feeding Behavior
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Patient Compliance
    Prostate-Specific Antigen
    Prostatic Neoplasms
    Treatment Outcome

    Pub Type(s)

    Controlled Clinical Trial
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16880426

    Citation

    Nguyen, Jacquelyn Y., et al. "Adoption of a Plant-based Diet By Patients With Recurrent Prostate Cancer." Integrative Cancer Therapies, vol. 5, no. 3, 2006, pp. 214-23.
    Nguyen JY, Major JM, Knott CJ, et al. Adoption of a plant-based diet by patients with recurrent prostate cancer. Integr Cancer Ther. 2006;5(3):214-23.
    Nguyen, J. Y., Major, J. M., Knott, C. J., Freeman, K. M., Downs, T. M., & Saxe, G. A. (2006). Adoption of a plant-based diet by patients with recurrent prostate cancer. Integrative Cancer Therapies, 5(3), pp. 214-23.
    Nguyen JY, et al. Adoption of a Plant-based Diet By Patients With Recurrent Prostate Cancer. Integr Cancer Ther. 2006;5(3):214-23. PubMed PMID: 16880426.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adoption of a plant-based diet by patients with recurrent prostate cancer. AU - Nguyen,Jacquelyn Y, AU - Major,Jacqueline M, AU - Knott,Cynthia J, AU - Freeman,Karen M, AU - Downs,Tracy M, AU - Saxe,Gordon A, PY - 2006/8/2/pubmed PY - 2006/12/9/medline PY - 2006/8/2/entrez SP - 214 EP - 23 JF - Integrative cancer therapies JO - Integr Cancer Ther VL - 5 IS - 3 N2 - The Western diet has been associated with prostate cancer incidence as well as risk of disease progression after treatment. Conversely, plant-based diets have been associated with decreased risks. A pilot clinical trial of a 6-month dietary change and stress reduction intervention for asymptomatic, hormonally untreated patients experiencing a consistently rising PSA level, the first sign of recurrence of prostate cancer after surgery or radiation therapy, was conducted to investigate the level of intake of plant-based foods and the relationship between intake and the change in the rate of PSA rise. A pre-post design was employed in which each patient served as his own control. In this multifaceted intervention, patients and their spouses were encouraged to adopt and maintain a plant-based diet. The prestudy rate of PSA rise (from the time of posttreatment recurrence to the start of the study) was ascertained by review of patients' medical records. Dietary assessments were performed and prostate-specific antigen (PSA) levels ascertained at baseline, prior to the start of intervention, and at 3 and 6 months. Changes in numbers of servings of plant-based food groups were calculated and compared with rates of PSA rise over the corresponding time intervals. Median intake of whole grains increased from 1.7 servings/d at baseline to 6.9 and 5.0 servings/d at 3 and 6 months, respectively. Median intake of vegetables increased from 2.8 servings/d at baseline to 5.0 and 4.8 servings/d at 3 and 6 months, respectively. The rate of PSA rise decreased when comparing the prestudy period (0.059) to the period from 0 to 3 months (-0.002, P < .01) and increased slightly, though not significantly, when comparing the period from 0 to 3 months to the period from 3 to 6 months (0.029, P = .4316). These results provide preliminary evidence that adoption of a plant-based diet is possible to achieve as well as to maintain for several months in patients with recurrent prostate cancer. Changes in the rate of rise in PSA, an indicator of disease progression, were in the opposite direction as changes in the intake of plant-based food groups, raising the provocative possibility that PSA may have inversely tracked intake of these foods and suggesting that adoption of a plant-based diet may have therapeutic potential in the management of this condition. SN - 1534-7354 UR - https://www.unboundmedicine.com/medline/citation/16880426/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/1534735406292053?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -