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Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats.
Synapse. 2006 Nov; 60(6):429-36.S

Abstract

The potential of repeated exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) to produce long-lasting changes in synaptic connections in a manner similar to other drugs of abuse was evaluated in Sprague-Dawley rats. For 12 days, rats received two i.p. injections per day (8 h apart) of vehicle, a low dose of Delta(9)-THC (0.5 mg/kg), or escalating doses of Delta(9)-THC (0.5-4.0 mg/kg). Thirty days later, they were evaluated for sensitized locomotor activity (during the night cycle) for 60 min on each of three trials. Using a within-groups design, rats were tested following an injection of vehicle, 0.5 mg/kg Delta(9)-THC or 2.0 mg/kg Delta(9)-THC. The rats showed no evidence of sensitized locomotor activity in any group. Twenty-four hours after the final sensitization test, their brains were removed and then processed for Golgi-Cox staining. Prior exposure to Delta(9)-THC (both the low dose and the escalating doses) increased the length of the dendrites as well as the number of dendritic branches in the shell of the nucleus accumbens and in the medial prefrontal cortex, but not in the hippocampus, striatum, orbital frontal cortex, parietal cortex, or occipital cortex. These results are similar to those evident in brains of rats sensitized to amphetamine, and support previous findings that cannabinoids promote DA activity in the mesolimbic DA system.

Authors+Show Affiliations

Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4. kolb@uleth.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16881072

Citation

Kolb, Bryan, et al. "Chronic Treatment With Delta-9-tetrahydrocannabinol Alters the Structure of Neurons in the Nucleus Accumbens Shell and Medial Prefrontal Cortex of Rats." Synapse (New York, N.Y.), vol. 60, no. 6, 2006, pp. 429-36.
Kolb B, Gorny G, Limebeer CL, et al. Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats. Synapse. 2006;60(6):429-36.
Kolb, B., Gorny, G., Limebeer, C. L., & Parker, L. A. (2006). Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats. Synapse (New York, N.Y.), 60(6), 429-36.
Kolb B, et al. Chronic Treatment With Delta-9-tetrahydrocannabinol Alters the Structure of Neurons in the Nucleus Accumbens Shell and Medial Prefrontal Cortex of Rats. Synapse. 2006;60(6):429-36. PubMed PMID: 16881072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats. AU - Kolb,Bryan, AU - Gorny,Grazyna, AU - Limebeer,Cheryl L, AU - Parker,Linda A, PY - 2006/8/2/pubmed PY - 2006/10/20/medline PY - 2006/8/2/entrez SP - 429 EP - 36 JF - Synapse (New York, N.Y.) JO - Synapse VL - 60 IS - 6 N2 - The potential of repeated exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) to produce long-lasting changes in synaptic connections in a manner similar to other drugs of abuse was evaluated in Sprague-Dawley rats. For 12 days, rats received two i.p. injections per day (8 h apart) of vehicle, a low dose of Delta(9)-THC (0.5 mg/kg), or escalating doses of Delta(9)-THC (0.5-4.0 mg/kg). Thirty days later, they were evaluated for sensitized locomotor activity (during the night cycle) for 60 min on each of three trials. Using a within-groups design, rats were tested following an injection of vehicle, 0.5 mg/kg Delta(9)-THC or 2.0 mg/kg Delta(9)-THC. The rats showed no evidence of sensitized locomotor activity in any group. Twenty-four hours after the final sensitization test, their brains were removed and then processed for Golgi-Cox staining. Prior exposure to Delta(9)-THC (both the low dose and the escalating doses) increased the length of the dendrites as well as the number of dendritic branches in the shell of the nucleus accumbens and in the medial prefrontal cortex, but not in the hippocampus, striatum, orbital frontal cortex, parietal cortex, or occipital cortex. These results are similar to those evident in brains of rats sensitized to amphetamine, and support previous findings that cannabinoids promote DA activity in the mesolimbic DA system. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/16881072/Chronic_treatment_with_Delta_9_tetrahydrocannabinol_alters_the_structure_of_neurons_in_the_nucleus_accumbens_shell_and_medial_prefrontal_cortex_of_rats_ DB - PRIME DP - Unbound Medicine ER -