Tags

Type your tag names separated by a space and hit enter

Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting.
J Med Assoc Thai. 2006 Jul; 89(7):974-8.JM

Abstract

BACKGROUND

PostExposure Prophylaxis (PEP) is widely used after exposures to Human Immunodeficiency Virus (HIV) to reduce the risk of infection in the healthcare setting. Few data are available on the safety and tolerability of Anti Retro Viral drugs (ARV) among Health Care Workers (HCWs) who are prescribed prophylaxis.

OBJECTIVE

To collect information about the safety and compliance of taking ARV for HIV PEP among HCWs.

MATERIAL AND METHOD

Retrospective review on registry data regarding occupational HIV exposures, the PEP regimens used, and the adverse events associated with PEP was performed.

RESULTS

During a five year-period, 820 episodes with occupational blood or body fluid exposures were reported Nurses (27%) were the largest group at risk. The most common type of exposure was percutaneous injuries (82%). Only 125 (15%) HCWs had occupational exposures to HIV, 64 HCWs were prescribed HIV PEP and 32 (50%) HCWs did not complete the PEP regimen as initially prescribed. The commonly prescribed ARV was zidovudine (38%), lamivudine (33%), and indinavir (11%). Overall, 18 (28%) HCWs reported symptoms while on PEP such as nausea (89%), vomiting (55%), and dizziness (39%). None of the HCWs had HIV seroconversion.

CONCLUSIONS

Adverse effects from HIV PEP were very common. Clinicians prescribing HIV PEP need to discuss with HCWs about PEP efficacy and side effects. Education efforts aimed at occupational exposure prevention are still important issues.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. rasal@mahidol.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16881429

Citation

Kiertiburanakul, Sasisopin, et al. "Use of HIV Postexposure Prophylaxis in Healthcare Workers After Occupational Exposure: a Thai University Hospital Setting." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 89, no. 7, 2006, pp. 974-8.
Kiertiburanakul S, Wannaying B, Tonsuttakul S, et al. Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting. J Med Assoc Thai. 2006;89(7):974-8.
Kiertiburanakul, S., Wannaying, B., Tonsuttakul, S., Kehachindawat, P., Apivanich, S., Somsakul, S., & Malathum, K. (2006). Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 89(7), 974-8.
Kiertiburanakul S, et al. Use of HIV Postexposure Prophylaxis in Healthcare Workers After Occupational Exposure: a Thai University Hospital Setting. J Med Assoc Thai. 2006;89(7):974-8. PubMed PMID: 16881429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting. AU - Kiertiburanakul,Sasisopin, AU - Wannaying,Bunchong, AU - Tonsuttakul,Sirirat, AU - Kehachindawat,Pranee, AU - Apivanich,Siriluk, AU - Somsakul,Somporn, AU - Malathum,Kumthorn, PY - 2006/8/3/pubmed PY - 2006/9/13/medline PY - 2006/8/3/entrez SP - 974 EP - 8 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 89 IS - 7 N2 - BACKGROUND: PostExposure Prophylaxis (PEP) is widely used after exposures to Human Immunodeficiency Virus (HIV) to reduce the risk of infection in the healthcare setting. Few data are available on the safety and tolerability of Anti Retro Viral drugs (ARV) among Health Care Workers (HCWs) who are prescribed prophylaxis. OBJECTIVE: To collect information about the safety and compliance of taking ARV for HIV PEP among HCWs. MATERIAL AND METHOD: Retrospective review on registry data regarding occupational HIV exposures, the PEP regimens used, and the adverse events associated with PEP was performed. RESULTS: During a five year-period, 820 episodes with occupational blood or body fluid exposures were reported Nurses (27%) were the largest group at risk. The most common type of exposure was percutaneous injuries (82%). Only 125 (15%) HCWs had occupational exposures to HIV, 64 HCWs were prescribed HIV PEP and 32 (50%) HCWs did not complete the PEP regimen as initially prescribed. The commonly prescribed ARV was zidovudine (38%), lamivudine (33%), and indinavir (11%). Overall, 18 (28%) HCWs reported symptoms while on PEP such as nausea (89%), vomiting (55%), and dizziness (39%). None of the HCWs had HIV seroconversion. CONCLUSIONS: Adverse effects from HIV PEP were very common. Clinicians prescribing HIV PEP need to discuss with HCWs about PEP efficacy and side effects. Education efforts aimed at occupational exposure prevention are still important issues. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/16881429/Use_of_HIV_Postexposure_Prophylaxis_in_healthcare_workers_after_occupational_exposure:_a_Thai_university_hospital_setting_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -