Tags

Type your tag names separated by a space and hit enter

Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together.
Acta Physiol Pharmacol Bulg. 1991; 17(4):17-26.AP

Abstract

In experiments on rats using passive avoidance with punishment reinforcement (step-through) and two-way active avoidance with punishment reinforcement (shuttle-box), we examined the effects on acquisition and retention of different combinations of the nootropic drugs meclofenoxate (Mf), citicholine (CCh), piracetam (Pc), the structural analogues of aniracetam p-P and p-F, standardized extract from ginseng roots (PG) and the psychostimulants caffeine (Caf) and amphetamine (Amph). Favorable effects (more pronounced improvement of learning and/or memory as compared to that caused by the drugs when given alone) were in some cases obtained by the combination Mf+Caf, Pc+Caf, CCh+Caf, p-F+Caf, Mf+CCh, as well as by the combination Mf+PG applied to rats with electroconvulsive shock-induced amnesia. However, in some cases the combined administration of two drugs with favorable effects on memory did not led to summation or potentiation but rather to disappearance of these effects. This was observed under certain experimental conditions with some combinations of Caf and CCh, Mf, Pc and p-P and with some combinations of Amph and Mf. Based on our earlier results and data in the literature, we present some considerations about the role of the neurotransmitter mechanisms of action of the drugs tested as neurochemical correlates of their effects on memory. It is suggested that the unfavorable results obtained in some cases with combinations of nootropics and psychostimulants are due to the possible disturbance of selective acquisition by the psychostimulant drug.

Authors+Show Affiliations

Petkov VD
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Konstantinova E
No affiliation info available
Petkov VV
No affiliation info available
Lazarova M
No affiliation info available
Petkova B
No affiliation info available

MeSH

AmphetamineAnimalsAvoidance LearningCaffeineCarbacholCentral Nervous System StimulantsDrug InteractionsLearningMaleMeclofenoxateMemoryNeurotransmitter AgentsPanaxPiracetamPlants, MedicinalPsychotropic DrugsPunishmentRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1688150

Citation

Petkov, V D., et al. "Modulation of the Effects On Learning and Memory of Nootropic Drugs and Central Stimulants when Applied Together." Acta Physiologica Et Pharmacologica Bulgarica, vol. 17, no. 4, 1991, pp. 17-26.
Petkov VD, Konstantinova E, Petkov VV, et al. Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together. Acta Physiol Pharmacol Bulg. 1991;17(4):17-26.
Petkov, V. D., Konstantinova, E., Petkov, V. V., Lazarova, M., & Petkova, B. (1991). Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together. Acta Physiologica Et Pharmacologica Bulgarica, 17(4), 17-26.
Petkov VD, et al. Modulation of the Effects On Learning and Memory of Nootropic Drugs and Central Stimulants when Applied Together. Acta Physiol Pharmacol Bulg. 1991;17(4):17-26. PubMed PMID: 1688150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together. AU - Petkov,V D, AU - Konstantinova,E, AU - Petkov,V V, AU - Lazarova,M, AU - Petkova,B, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 17 EP - 26 JF - Acta physiologica et pharmacologica Bulgarica JO - Acta Physiol Pharmacol Bulg VL - 17 IS - 4 N2 - In experiments on rats using passive avoidance with punishment reinforcement (step-through) and two-way active avoidance with punishment reinforcement (shuttle-box), we examined the effects on acquisition and retention of different combinations of the nootropic drugs meclofenoxate (Mf), citicholine (CCh), piracetam (Pc), the structural analogues of aniracetam p-P and p-F, standardized extract from ginseng roots (PG) and the psychostimulants caffeine (Caf) and amphetamine (Amph). Favorable effects (more pronounced improvement of learning and/or memory as compared to that caused by the drugs when given alone) were in some cases obtained by the combination Mf+Caf, Pc+Caf, CCh+Caf, p-F+Caf, Mf+CCh, as well as by the combination Mf+PG applied to rats with electroconvulsive shock-induced amnesia. However, in some cases the combined administration of two drugs with favorable effects on memory did not led to summation or potentiation but rather to disappearance of these effects. This was observed under certain experimental conditions with some combinations of Caf and CCh, Mf, Pc and p-P and with some combinations of Amph and Mf. Based on our earlier results and data in the literature, we present some considerations about the role of the neurotransmitter mechanisms of action of the drugs tested as neurochemical correlates of their effects on memory. It is suggested that the unfavorable results obtained in some cases with combinations of nootropics and psychostimulants are due to the possible disturbance of selective acquisition by the psychostimulant drug. SN - 0323-9950 UR - https://www.unboundmedicine.com/medline/citation/1688150/Modulation_of_the_effects_on_learning_and_memory_of_nootropic_drugs_and_central_stimulants_when_applied_together_ DB - PRIME DP - Unbound Medicine ER -