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Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine.
J Agric Food Chem. 2006 Aug 09; 54(16):6075-8.JA

Abstract

In Korea, Orostachys japonicus has been used traditionally as a drug and health food. The aim of this study was to investigate possible inhibitory effects of O. japonicus extracts on the formation of N-nitrosodimethylamines (NDMA). Chloroform extraction was the most effective method for recovering the highest number of phenolic compounds and flavonoids; in these extracts the greatest nitrite-scavenging activity and inhibition of NDMA formation occurred at pH 2.5. The chloroform extract was separated into 10 fractions (J1-J10); fraction J4 inhibited NDMA formation by 90.1 +/- 0.4%. This fraction was then separated into five subfractions (J4-1-J4-5) using a silica gel column. Subfractions J4-2 [(+)-catechin] and J4-4 (3,4-dihdroxybenzoic acid) inhibited NDMA formation by 89.5 +/- 0.9 and 77.6 +/- 0.8%, respectively.

Authors+Show Affiliations

Department of Food Science and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16881719

Citation

Choi, Sun Young, et al. "Inhibitory Effects of Orostachys Japonicus Extracts On the Formation of N-nitrosodimethylamine." Journal of Agricultural and Food Chemistry, vol. 54, no. 16, 2006, pp. 6075-8.
Choi SY, Chung MJ, Seo WD, et al. Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine. J Agric Food Chem. 2006;54(16):6075-8.
Choi, S. Y., Chung, M. J., Seo, W. D., Shin, J. H., Shon, M. Y., & Sung, N. J. (2006). Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine. Journal of Agricultural and Food Chemistry, 54(16), 6075-8.
Choi SY, et al. Inhibitory Effects of Orostachys Japonicus Extracts On the Formation of N-nitrosodimethylamine. J Agric Food Chem. 2006 Aug 9;54(16):6075-8. PubMed PMID: 16881719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine. AU - Choi,Sun Young, AU - Chung,Mi Ja, AU - Seo,Woo Duck, AU - Shin,Jung Hye, AU - Shon,Mi Yae, AU - Sung,Nak Ju, PY - 2006/8/3/pubmed PY - 2006/9/22/medline PY - 2006/8/3/entrez SP - 6075 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 16 N2 - In Korea, Orostachys japonicus has been used traditionally as a drug and health food. The aim of this study was to investigate possible inhibitory effects of O. japonicus extracts on the formation of N-nitrosodimethylamines (NDMA). Chloroform extraction was the most effective method for recovering the highest number of phenolic compounds and flavonoids; in these extracts the greatest nitrite-scavenging activity and inhibition of NDMA formation occurred at pH 2.5. The chloroform extract was separated into 10 fractions (J1-J10); fraction J4 inhibited NDMA formation by 90.1 +/- 0.4%. This fraction was then separated into five subfractions (J4-1-J4-5) using a silica gel column. Subfractions J4-2 [(+)-catechin] and J4-4 (3,4-dihdroxybenzoic acid) inhibited NDMA formation by 89.5 +/- 0.9 and 77.6 +/- 0.8%, respectively. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16881719/Inhibitory_effects_of_Orostachys_japonicus_extracts_on_the_formation_of_N_nitrosodimethylamine_ L2 - https://doi.org/10.1021/jf060845f DB - PRIME DP - Unbound Medicine ER -