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Anti-centromere antibodies in patients with systemic lupus erythematosus.
Scand J Rheumatol 2006 Jul-Aug; 35(4):290-4SJ

Abstract

BACKGROUND

Anti-centromere autoantibodies (ACA) are frequently detected in systemic sclerosis (SScl), especially in the calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, in which a prevalence of 55% has been reported. The presence of ACA in systemic lupus erythematosus (SLE) is so rare that its detection can raise serious doubts about the validity of the diagnosis.

OBJECTIVE

To determine the frequency of ACA positive subjects from a wide monocentric cohort of SLE patients and analyse the clinical and biological characteristics of this group.

METHODS

Five hundred and sixty consecutive SLE patients were systematically analysed for the presence of ACA and other autoantibodies using indirect immunofluorescence, counter-immunoelectrophoresis, double immunodiffusion, enzyme-linked immunosorbent assay (ELISA), and Western-blot.

RESULTS

ACA were detected in 11 SLE patients (1.9%); all of them were women. The CENP-B-specific ELISA was positive in all patients. The main clinical features of scleroderma (cutaneous sclerosis, sclerodactylia, digital ulcers, or pulmonary fibrosis) were not present in these patients, who did not differ clinically from the whole SLE group.

CONCLUSIONS

ACA can be detected in patients with genuine SLE without concurrent scleroderma. Therefore, the presence of this antibody does not preclude the possibility of the diagnosis of SLE. In addition, SLE patients with ACA do not represent a different clinical subgroup.

Authors+Show Affiliations

Department of Immunology, Hospitales Universitarios Virgen del Rocio, Avenida Manuel Siurot s/n, 41013 Seville, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16882593

Citation

Respaldiza, N, et al. "Anti-centromere Antibodies in Patients With Systemic Lupus Erythematosus." Scandinavian Journal of Rheumatology, vol. 35, no. 4, 2006, pp. 290-4.
Respaldiza N, Wichmann I, Ocaña C, et al. Anti-centromere antibodies in patients with systemic lupus erythematosus. Scand J Rheumatol. 2006;35(4):290-4.
Respaldiza, N., Wichmann, I., Ocaña, C., Garcia-Hernandez, F. J., Castillo, M. J., Magariño, M. I., ... Nuñez-Roldan, A. (2006). Anti-centromere antibodies in patients with systemic lupus erythematosus. Scandinavian Journal of Rheumatology, 35(4), pp. 290-4.
Respaldiza N, et al. Anti-centromere Antibodies in Patients With Systemic Lupus Erythematosus. Scand J Rheumatol. 2006;35(4):290-4. PubMed PMID: 16882593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-centromere antibodies in patients with systemic lupus erythematosus. AU - Respaldiza,N, AU - Wichmann,I, AU - Ocaña,C, AU - Garcia-Hernandez,F J, AU - Castillo,M J, AU - Magariño,M I, AU - Magariño,R, AU - Torres,A, AU - Sanchez-Roman,J, AU - Nuñez-Roldan,A, PY - 2006/8/3/pubmed PY - 2006/10/28/medline PY - 2006/8/3/entrez SP - 290 EP - 4 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 35 IS - 4 N2 - BACKGROUND: Anti-centromere autoantibodies (ACA) are frequently detected in systemic sclerosis (SScl), especially in the calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, in which a prevalence of 55% has been reported. The presence of ACA in systemic lupus erythematosus (SLE) is so rare that its detection can raise serious doubts about the validity of the diagnosis. OBJECTIVE: To determine the frequency of ACA positive subjects from a wide monocentric cohort of SLE patients and analyse the clinical and biological characteristics of this group. METHODS: Five hundred and sixty consecutive SLE patients were systematically analysed for the presence of ACA and other autoantibodies using indirect immunofluorescence, counter-immunoelectrophoresis, double immunodiffusion, enzyme-linked immunosorbent assay (ELISA), and Western-blot. RESULTS: ACA were detected in 11 SLE patients (1.9%); all of them were women. The CENP-B-specific ELISA was positive in all patients. The main clinical features of scleroderma (cutaneous sclerosis, sclerodactylia, digital ulcers, or pulmonary fibrosis) were not present in these patients, who did not differ clinically from the whole SLE group. CONCLUSIONS: ACA can be detected in patients with genuine SLE without concurrent scleroderma. Therefore, the presence of this antibody does not preclude the possibility of the diagnosis of SLE. In addition, SLE patients with ACA do not represent a different clinical subgroup. SN - 0300-9742 UR - https://www.unboundmedicine.com/medline/citation/16882593/Anti_centromere_antibodies_in_patients_with_systemic_lupus_erythematosus_ L2 - http://www.tandfonline.com/doi/full/10.1080/03009740600588376 DB - PRIME DP - Unbound Medicine ER -