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[Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Aug; 23(4):427-30.ZY

Abstract

OBJECTIVE

To assess the association of haplotype of HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection in Han population of north China.

METHODS

Two hundred and seven chronic hepatitis B (HB) patients, two hundred and twelve chronic asymptomatic hepatitis B virus (HBV) carriers (HBV carrier) and one hundred and forty-eight self-limited HBV infection were investigated for HLA-DRB1 and HLA-DQA1 alleles by sequence specific-polymerase chain reaction (PCR-SSP).

RESULTS

The frequency of DRB1*04-DQA1*0301 haplotype was 10.03% in self-limited HBV infection subjects, significantly higher than that in chronic HB patients (3.66%) (P=0.0005)슩the frequency of DRB1*15/*16-DQA1*0102 haplotype was 6.80% in self-limited HBV infection subjects, significantly higher than 1.94% in chronic HB patients (P=0.0012) and 1.65% in asymptomatic HBV carriers (P=0.0004)슩while the frequency of DRB1*04-DQA1*0302 haplotype was 3.10% in chronic HB patients, higher than that in self-limited HBV infection subjects (0.39%) (P=0.0077).

CONCLUSION

Individuals with different haplotypes composed of HLA-DRB1 and HLA-DQA1 might have different outcomes of HBV infection.

Authors+Show Affiliations

Department of Epidemiology & Statistics, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16883532

Citation

Lu, Liang-ping, et al. "[Association of Haplotype Formed On HLA-DRB1 and HLA-DQA1 Alleles With Outcomes of Hepatitis B Virus Infection]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 23, no. 4, 2006, pp. 427-30.
Lu LP, Li XW, Liu Y, et al. [Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006;23(4):427-30.
Lu, L. P., Li, X. W., Liu, Y., Sun, G. C., Chen, Z. H., Zhu, X. L., Hu, Q. Y., & Li, H. (2006). [Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 23(4), 427-30.
Lu LP, et al. [Association of Haplotype Formed On HLA-DRB1 and HLA-DQA1 Alleles With Outcomes of Hepatitis B Virus Infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006;23(4):427-30. PubMed PMID: 16883532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection]. AU - Lu,Liang-ping, AU - Li,Xing-wang, AU - Liu,Ying, AU - Sun,Guo-chang, AU - Chen,Zhi-hai, AU - Zhu,Xi-lin, AU - Hu,Quan-you, AU - Li,Hui, PY - 2006/8/3/pubmed PY - 2009/3/28/medline PY - 2006/8/3/entrez SP - 427 EP - 30 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 23 IS - 4 N2 - OBJECTIVE: To assess the association of haplotype of HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection in Han population of north China. METHODS: Two hundred and seven chronic hepatitis B (HB) patients, two hundred and twelve chronic asymptomatic hepatitis B virus (HBV) carriers (HBV carrier) and one hundred and forty-eight self-limited HBV infection were investigated for HLA-DRB1 and HLA-DQA1 alleles by sequence specific-polymerase chain reaction (PCR-SSP). RESULTS: The frequency of DRB1*04-DQA1*0301 haplotype was 10.03% in self-limited HBV infection subjects, significantly higher than that in chronic HB patients (3.66%) (P=0.0005)슩the frequency of DRB1*15/*16-DQA1*0102 haplotype was 6.80% in self-limited HBV infection subjects, significantly higher than 1.94% in chronic HB patients (P=0.0012) and 1.65% in asymptomatic HBV carriers (P=0.0004)슩while the frequency of DRB1*04-DQA1*0302 haplotype was 3.10% in chronic HB patients, higher than that in self-limited HBV infection subjects (0.39%) (P=0.0077). CONCLUSION: Individuals with different haplotypes composed of HLA-DRB1 and HLA-DQA1 might have different outcomes of HBV infection. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/16883532/[Association_of_haplotype_formed_on_HLA_DRB1_and_HLA_DQA1_alleles_with_outcomes_of_hepatitis_B_virus_infection]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -