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Kettapeptin: isolation, structure elucidation and activity of a new hexadepsipeptide antibiotic from a terrestrial Streptomyces sp.
J Antibiot (Tokyo). 2006 May; 59(5):309-14.JA

Abstract

The ethyl acetate extract of the Streptomyces sp. isolate GW99/1572 exhibited significant biological activity against Gram-positive bacteria and delivered kettapeptin (1), a new hexadepsipeptide antibiotic of the azinothricin type. The structure was elucidated by various 1D and 2D NMR techniques, mass spectrometry and by comparison of the NMR data with those of closely related antibiotics. The absolute configuration of the compound was derived by crystal structure analysis and by comparison with the optical rotation data of related compounds.

Authors+Show Affiliations

Maskey RP
: Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammanstrasse 2, D-37077 Göttingen, Germany.
Fotso S
No affiliation info available
Sevvana M
No affiliation info available
Usón I
No affiliation info available
Grün-Wollny I
No affiliation info available
Laatsch H
No affiliation info available

MeSH

Anti-Infective AgentsAntibiotics, AntineoplasticCell Line, TumorCrystallography, X-RayDepsipeptidesHumansMicrobial Sensitivity TestsModels, MolecularMolecular StructureNuclear Magnetic Resonance, BiomolecularOptical RotationPeptides, CyclicSpectrometry, Mass, Electrospray IonizationSpectrophotometry, InfraredSpectrophotometry, UltravioletStreptomyces

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16883782

Citation

Maskey, Rajendra P., et al. "Kettapeptin: Isolation, Structure Elucidation and Activity of a New Hexadepsipeptide Antibiotic From a Terrestrial Streptomyces Sp." The Journal of Antibiotics, vol. 59, no. 5, 2006, pp. 309-14.
Maskey RP, Fotso S, Sevvana M, et al. Kettapeptin: isolation, structure elucidation and activity of a new hexadepsipeptide antibiotic from a terrestrial Streptomyces sp. J Antibiot (Tokyo). 2006;59(5):309-14.
Maskey, R. P., Fotso, S., Sevvana, M., Usón, I., Grün-Wollny, I., & Laatsch, H. (2006). Kettapeptin: isolation, structure elucidation and activity of a new hexadepsipeptide antibiotic from a terrestrial Streptomyces sp. The Journal of Antibiotics, 59(5), 309-14.
Maskey RP, et al. Kettapeptin: Isolation, Structure Elucidation and Activity of a New Hexadepsipeptide Antibiotic From a Terrestrial Streptomyces Sp. J Antibiot (Tokyo). 2006;59(5):309-14. PubMed PMID: 16883782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kettapeptin: isolation, structure elucidation and activity of a new hexadepsipeptide antibiotic from a terrestrial Streptomyces sp. AU - Maskey,Rajendra P, AU - Fotso,Serge, AU - Sevvana,Madhumati, AU - Usón,Isabel, AU - Grün-Wollny,Iris, AU - Laatsch,Hartmut, PY - 2006/8/4/pubmed PY - 2006/8/31/medline PY - 2006/8/4/entrez SP - 309 EP - 14 JF - The Journal of antibiotics JO - J Antibiot (Tokyo) VL - 59 IS - 5 N2 - The ethyl acetate extract of the Streptomyces sp. isolate GW99/1572 exhibited significant biological activity against Gram-positive bacteria and delivered kettapeptin (1), a new hexadepsipeptide antibiotic of the azinothricin type. The structure was elucidated by various 1D and 2D NMR techniques, mass spectrometry and by comparison of the NMR data with those of closely related antibiotics. The absolute configuration of the compound was derived by crystal structure analysis and by comparison with the optical rotation data of related compounds. SN - 0021-8820 UR - https://www.unboundmedicine.com/medline/citation/16883782/Kettapeptin:_isolation_structure_elucidation_and_activity_of_a_new_hexadepsipeptide_antibiotic_from_a_terrestrial_Streptomyces_sp_ L2 - https://doi.org/10.1038/ja.2006.44 DB - PRIME DP - Unbound Medicine ER -