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Human papillomavirus genotypes associated with cervical neoplasia in India.
Int J Gynecol Cancer. 2006 Jul-Aug; 16(4):1591-5.IJ

Abstract

The aim of this study was to determine the prevalence of human papillomavirus (HPV) genotypes in tissue with cervical neoplasias in patients from south and east India. Cross-sectional cervical tissue was obtained from 100 patients from south India and 30 patients from east India who had a biopsy for clinically invasive cervical cancer or cervical intraepithelial neoplasia (CIN) in a tertiary care hospital in India. DNA amplification was done with biotinylated PGMY 09/11 primers, and the line blot assay was used to determine the HPV genotype. HPV DNA was detected in 95% of invasive cancers (113/119) and 91% of CINs (10/11). A single HPV type was found in 100 women (77%), and mixed infections were found in 23 women (18%). HPV 16 (60%) and HPV 18 (14%) were the most frequent types, but 16 other types (26, 31, 33, 35, 42, 45, 51, 52, 53, 56, 58, 61, 62, 64, 81, and 82) were also identified. HPV 16 was present in 63% of patients from south India and in 50% of patients from east India, while HPV 18 was present in 12% and 20%, respectively. There are several high-risk HPV types associated with cervical neoplasias of which types 16 and 18 are the most common.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, India. abraham@cmcvellore.ac.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16884371

Citation

Peedicayil, A, et al. "Human Papillomavirus Genotypes Associated With Cervical Neoplasia in India." International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, vol. 16, no. 4, 2006, pp. 1591-5.
Peedicayil A, Abraham P, Sathish N, et al. Human papillomavirus genotypes associated with cervical neoplasia in India. Int J Gynecol Cancer. 2006;16(4):1591-5.
Peedicayil, A., Abraham, P., Sathish, N., John, S., Shah, K., Sridharan, G., & Gravitt, P. (2006). Human papillomavirus genotypes associated with cervical neoplasia in India. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, 16(4), 1591-5.
Peedicayil A, et al. Human Papillomavirus Genotypes Associated With Cervical Neoplasia in India. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1591-5. PubMed PMID: 16884371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human papillomavirus genotypes associated with cervical neoplasia in India. AU - Peedicayil,A, AU - Abraham,P, AU - Sathish,N, AU - John,S, AU - Shah,K, AU - Sridharan,G, AU - Gravitt,P, PY - 2006/8/4/pubmed PY - 2006/12/9/medline PY - 2006/8/4/entrez SP - 1591 EP - 5 JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society JO - Int J Gynecol Cancer VL - 16 IS - 4 N2 - The aim of this study was to determine the prevalence of human papillomavirus (HPV) genotypes in tissue with cervical neoplasias in patients from south and east India. Cross-sectional cervical tissue was obtained from 100 patients from south India and 30 patients from east India who had a biopsy for clinically invasive cervical cancer or cervical intraepithelial neoplasia (CIN) in a tertiary care hospital in India. DNA amplification was done with biotinylated PGMY 09/11 primers, and the line blot assay was used to determine the HPV genotype. HPV DNA was detected in 95% of invasive cancers (113/119) and 91% of CINs (10/11). A single HPV type was found in 100 women (77%), and mixed infections were found in 23 women (18%). HPV 16 (60%) and HPV 18 (14%) were the most frequent types, but 16 other types (26, 31, 33, 35, 42, 45, 51, 52, 53, 56, 58, 61, 62, 64, 81, and 82) were also identified. HPV 16 was present in 63% of patients from south India and in 50% of patients from east India, while HPV 18 was present in 12% and 20%, respectively. There are several high-risk HPV types associated with cervical neoplasias of which types 16 and 18 are the most common. SN - 1048-891X UR - https://www.unboundmedicine.com/medline/citation/16884371/Human_papillomavirus_genotypes_associated_with_cervical_neoplasia_in_India_ L2 - https://ijgc.bmj.com/lookup/pmidlookup?view=long&pmid=16884371 DB - PRIME DP - Unbound Medicine ER -