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Visual outcomes in children with juvenile idiopathic arthritis-associated uveitis.
Ophthalmology. 2006 Oct; 113(10):1874-7.O

Abstract

PURPOSE

To analyze visual outcomes in children affected by juvenile idiopathic arthritis (JIA)-associated uveitis.

DESIGN

Retrospective interventional case series.

PARTICIPANTS

Eighty-nine children with JIA-associated uveitis.

METHODS

Charts of children with JIA-associated uveitis were reviewed.

MAIN OUTCOME MEASURE

Change in patients' visual acuities (VAs).

RESULTS

Of 269 children with uveitic syndromes referred, 89 (33%) had JIA-associated uveitis. The process was bilateral in 76 children. Seventy-three patients were female, and 84% of patients were Caucasian. Mean age of onset of uveitis was 5.7 years. Mean follow-up was 2.96 years. Antinuclear antibody positivity was detected in 56 patients, 44 of them female. Patients with JIA-associated uveitis developed numerous complications in the course of their disease: of 165 affected eyes, 105 (64%) developed cataracts, 33 (20%) developed increased intraocular pressure, and 76 (46%) developed band keratopathy; posterior synechiae were present in 96 (58%). Of 89 children, 73% were treated with immunomodulators, 40% were treated with nonsteroidal antiinflammatory agents alone or in combination with immunomodulators, and 21% were treated with topical and/or systemic steroids. Of 65 children who required immunomodulation, only one chemotherapeutic agent was used in 30, two agents in 21, and > or =3 in 14. Visual acuities of 65 children (122 eyes) were documented and compared at standard intervals. By mixed-models linear regression, improvement in VA of 0.03 logarithm of the minimum angle of resolution units per year was not found to be statistically significant (standard error, 0.02, P = 0.089).

CONCLUSIONS

Juvenile idiopathic arthritis-associated uveitis is a sight-threatening disease. However, much of the children's vision can be preserved if patients are treated appropriately.

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Publisher Full Text

Authors+Show Affiliations

Kump LI
Massachusetts Eye Research and Surgery Institute, Cambridge, Massachusetts, USA.
Castañeda RA
No affiliation info available
Androudi SN
No affiliation info available
Reed GF
No affiliation info available
Foster CS
No affiliation info available

MeSH

AdolescentAge of OnsetAnti-Inflammatory Agents, Non-SteroidalAntibodies, AntinuclearArthritis, JuvenileChildChild, PreschoolFemaleFollow-Up StudiesGlucocorticoidsHumansImmunologic FactorsInfantMaleRetrospective StudiesUveitis, AnteriorVisual Acuity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16884776

Citation

Kump, Leila I., et al. "Visual Outcomes in Children With Juvenile Idiopathic Arthritis-associated Uveitis." Ophthalmology, vol. 113, no. 10, 2006, pp. 1874-7.
Kump LI, Castañeda RA, Androudi SN, et al. Visual outcomes in children with juvenile idiopathic arthritis-associated uveitis. Ophthalmology. 2006;113(10):1874-7.
Kump, L. I., Castañeda, R. A., Androudi, S. N., Reed, G. F., & Foster, C. S. (2006). Visual outcomes in children with juvenile idiopathic arthritis-associated uveitis. Ophthalmology, 113(10), 1874-7.
Kump LI, et al. Visual Outcomes in Children With Juvenile Idiopathic Arthritis-associated Uveitis. Ophthalmology. 2006;113(10):1874-7. PubMed PMID: 16884776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual outcomes in children with juvenile idiopathic arthritis-associated uveitis. AU - Kump,Leila I, AU - Castañeda,René A Cervantes, AU - Androudi,Sofia N, AU - Reed,George F, AU - Foster,C Stephen, Y1 - 2006/08/01/ PY - 2005/11/01/received PY - 2006/04/19/revised PY - 2006/05/14/accepted PY - 2006/8/4/pubmed PY - 2006/10/14/medline PY - 2006/8/4/entrez SP - 1874 EP - 7 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 10 N2 - PURPOSE: To analyze visual outcomes in children affected by juvenile idiopathic arthritis (JIA)-associated uveitis. DESIGN: Retrospective interventional case series. PARTICIPANTS: Eighty-nine children with JIA-associated uveitis. METHODS: Charts of children with JIA-associated uveitis were reviewed. MAIN OUTCOME MEASURE: Change in patients' visual acuities (VAs). RESULTS: Of 269 children with uveitic syndromes referred, 89 (33%) had JIA-associated uveitis. The process was bilateral in 76 children. Seventy-three patients were female, and 84% of patients were Caucasian. Mean age of onset of uveitis was 5.7 years. Mean follow-up was 2.96 years. Antinuclear antibody positivity was detected in 56 patients, 44 of them female. Patients with JIA-associated uveitis developed numerous complications in the course of their disease: of 165 affected eyes, 105 (64%) developed cataracts, 33 (20%) developed increased intraocular pressure, and 76 (46%) developed band keratopathy; posterior synechiae were present in 96 (58%). Of 89 children, 73% were treated with immunomodulators, 40% were treated with nonsteroidal antiinflammatory agents alone or in combination with immunomodulators, and 21% were treated with topical and/or systemic steroids. Of 65 children who required immunomodulation, only one chemotherapeutic agent was used in 30, two agents in 21, and > or =3 in 14. Visual acuities of 65 children (122 eyes) were documented and compared at standard intervals. By mixed-models linear regression, improvement in VA of 0.03 logarithm of the minimum angle of resolution units per year was not found to be statistically significant (standard error, 0.02, P = 0.089). CONCLUSIONS: Juvenile idiopathic arthritis-associated uveitis is a sight-threatening disease. However, much of the children's vision can be preserved if patients are treated appropriately. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16884776/Visual_outcomes_in_children_with_juvenile_idiopathic_arthritis_associated_uveitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00679-8 DB - PRIME DP - Unbound Medicine ER -