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Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study.
Ophthalmology. 2006 Oct; 113(10):1827-31.O

Abstract

PURPOSE

To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG).

DESIGN

Prospective population-based cohort study.

PARTICIPANTS

Participants ages > or =55 years from the Rotterdam Study, The Netherlands.

METHODS

Participants at risk for incident OAG (iOAG) underwent at baseline (1990-1993) and follow-up (1997-1999) the same ophthalmic examination including intraocular pressure (IOP) measurement, visual field testing, and simultaneous stereo optic disc photography. At baseline, diabetes mellitus was defined as the use of antidiabetic medication and/or a random or postload glucose value > or =11.1 mmol/l. The diagnosis of OAG was made with an algorithm based on optic disc measures and visual fields, independent of the IOP.

MAIN OUTCOME MEASURE

Incident OAG.

RESULTS

In total, 3837 participants without OAG at baseline were reexamined. After a mean follow-up time of 6.5 years, iOAG developed in 87 persons. The relative risk of iOAG associated with baseline diabetes was 0.82 (0.33-2.05). After adjustment for age, gender, follow-up time, IOP, IOP-lowering treatment, body mass index, and systemic hypertension, the relative risk of iOAG was 0.65 (0.25-1.64).

CONCLUSIONS

In this prospective population-based study, diabetes mellitus was not a risk factor for OAG.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16884777

Citation

de Voogd, Simone, et al. "Is Diabetes Mellitus a Risk Factor for Open-angle Glaucoma? the Rotterdam Study." Ophthalmology, vol. 113, no. 10, 2006, pp. 1827-31.
de Voogd S, Ikram MK, Wolfs RC, et al. Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study. Ophthalmology. 2006;113(10):1827-31.
de Voogd, S., Ikram, M. K., Wolfs, R. C., Jansonius, N. M., Witteman, J. C., Hofman, A., & de Jong, P. T. (2006). Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study. Ophthalmology, 113(10), 1827-31.
de Voogd S, et al. Is Diabetes Mellitus a Risk Factor for Open-angle Glaucoma? the Rotterdam Study. Ophthalmology. 2006;113(10):1827-31. PubMed PMID: 16884777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study. AU - de Voogd,Simone, AU - Ikram,M Kamran, AU - Wolfs,Roger C W, AU - Jansonius,Nomdo M, AU - Witteman,Jacqueline C M, AU - Hofman,Albert, AU - de Jong,Paulus T V M, Y1 - 2006/08/01/ PY - 2005/09/07/received PY - 2006/03/23/revised PY - 2006/03/27/accepted PY - 2006/8/4/pubmed PY - 2006/10/14/medline PY - 2006/8/4/entrez SP - 1827 EP - 31 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 10 N2 - PURPOSE: To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG). DESIGN: Prospective population-based cohort study. PARTICIPANTS: Participants ages > or =55 years from the Rotterdam Study, The Netherlands. METHODS: Participants at risk for incident OAG (iOAG) underwent at baseline (1990-1993) and follow-up (1997-1999) the same ophthalmic examination including intraocular pressure (IOP) measurement, visual field testing, and simultaneous stereo optic disc photography. At baseline, diabetes mellitus was defined as the use of antidiabetic medication and/or a random or postload glucose value > or =11.1 mmol/l. The diagnosis of OAG was made with an algorithm based on optic disc measures and visual fields, independent of the IOP. MAIN OUTCOME MEASURE: Incident OAG. RESULTS: In total, 3837 participants without OAG at baseline were reexamined. After a mean follow-up time of 6.5 years, iOAG developed in 87 persons. The relative risk of iOAG associated with baseline diabetes was 0.82 (0.33-2.05). After adjustment for age, gender, follow-up time, IOP, IOP-lowering treatment, body mass index, and systemic hypertension, the relative risk of iOAG was 0.65 (0.25-1.64). CONCLUSIONS: In this prospective population-based study, diabetes mellitus was not a risk factor for OAG. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16884777/Is_diabetes_mellitus_a_risk_factor_for_open_angle_glaucoma_The_Rotterdam_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00692-0 DB - PRIME DP - Unbound Medicine ER -