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Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats.
Drug Alcohol Depend. 2007 Jan 12; 86(2-3):183-90.DA

Abstract

In recent work we have documented lasting adverse neurochemical and behavioural effects in rats given short-term 'binge' dosing with methylenedioxymethamphetamine (MDMA, Ecstasy), methamphetamine (METH) or their combination. Here we investigated whether similar effects persist in rats given 16 weekly injections followed by a 10 week period of abstinence. Female rats received MDMA (8 mg/kg, i.p.), METH (8 mg/kg), or a MDMA/METH combination (4 mg/kg MDMA + 4 mg/kg METH), once a week for 16 weeks, with locomotor activity and body temperature measured on weeks 1, 8 and 16. The MDMA and MDMA/METH groups showed acute drug-induced hyperthermia on week 1 only. MDMA-treated rats demonstrated an acute hyperactivity while METH and MDMA/METH treated rats showed pronounced stereotypy. Seven weeks after drug-treatment concluded, a decrease in social interaction was observed in all chronically drug-treated rats. No group differences were evident on the emergence, object recognition or forced swim tests. Neurochemical analysis revealed modest noradrenaline and serotonin depletion in chronically treated rats that was not evident following a single equivalent administration. These results indicate that although chronic, intermittent exposure to MDMA, METH or their combination, may not lead to significant long-term monoamine depletion, lasting adverse behavioural effects may persist, especially those related to social behaviour.

Authors+Show Affiliations

School of Psychology, University of Sydney, NSW 2006, Australia. kclemens@psy.unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16884865

Citation

Clemens, Kelly J., et al. "Repeated Weekly Exposure to MDMA, Methamphetamine or Their Combination: Long-term Behavioural and Neurochemical Effects in Rats." Drug and Alcohol Dependence, vol. 86, no. 2-3, 2007, pp. 183-90.
Clemens KJ, Cornish JL, Hunt GE, et al. Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats. Drug Alcohol Depend. 2007;86(2-3):183-90.
Clemens, K. J., Cornish, J. L., Hunt, G. E., & McGregor, I. S. (2007). Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats. Drug and Alcohol Dependence, 86(2-3), 183-90.
Clemens KJ, et al. Repeated Weekly Exposure to MDMA, Methamphetamine or Their Combination: Long-term Behavioural and Neurochemical Effects in Rats. Drug Alcohol Depend. 2007 Jan 12;86(2-3):183-90. PubMed PMID: 16884865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats. AU - Clemens,Kelly J, AU - Cornish,Jennifer L, AU - Hunt,Glenn E, AU - McGregor,Iain S, Y1 - 2006/08/01/ PY - 2006/02/06/received PY - 2006/06/01/revised PY - 2006/06/10/accepted PY - 2006/8/4/pubmed PY - 2007/6/22/medline PY - 2006/8/4/entrez SP - 183 EP - 90 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 86 IS - 2-3 N2 - In recent work we have documented lasting adverse neurochemical and behavioural effects in rats given short-term 'binge' dosing with methylenedioxymethamphetamine (MDMA, Ecstasy), methamphetamine (METH) or their combination. Here we investigated whether similar effects persist in rats given 16 weekly injections followed by a 10 week period of abstinence. Female rats received MDMA (8 mg/kg, i.p.), METH (8 mg/kg), or a MDMA/METH combination (4 mg/kg MDMA + 4 mg/kg METH), once a week for 16 weeks, with locomotor activity and body temperature measured on weeks 1, 8 and 16. The MDMA and MDMA/METH groups showed acute drug-induced hyperthermia on week 1 only. MDMA-treated rats demonstrated an acute hyperactivity while METH and MDMA/METH treated rats showed pronounced stereotypy. Seven weeks after drug-treatment concluded, a decrease in social interaction was observed in all chronically drug-treated rats. No group differences were evident on the emergence, object recognition or forced swim tests. Neurochemical analysis revealed modest noradrenaline and serotonin depletion in chronically treated rats that was not evident following a single equivalent administration. These results indicate that although chronic, intermittent exposure to MDMA, METH or their combination, may not lead to significant long-term monoamine depletion, lasting adverse behavioural effects may persist, especially those related to social behaviour. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/16884865/Repeated_weekly_exposure_to_MDMA_methamphetamine_or_their_combination:_long_term_behavioural_and_neurochemical_effects_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(06)00225-0 DB - PRIME DP - Unbound Medicine ER -