Tags

Type your tag names separated by a space and hit enter

Use of mesalazine in diverticular disease.
J Clin Gastroenterol. 2006 Aug; 40 Suppl 3:S155-9.JC

Abstract

Diverticular disease includes a spectrum of conditions sharing the underlying pathology of acquired diverticula of the colon: symptomatic uncomplicated diverticular disease, recurrent symptomatic uncomplicated diverticular disease, and complicated diverticular disease. Goals of therapy in diverticular disease should be to improve symptoms and to prevent recurrent attacks in symptomatic uncomplicated diverticular disease, and to prevent the complications of disease such as diverticulitis. Inflammation seems to play a key role in all forms of the disease. This is the rationale for the use of anti-inflammatory drugs such as mesalazine. Inflammation in such diseases seems to be generated by a heightened production of proinflammatory cytokines, reduced anti-inflammatory cytokines, and enhanced intramucosal synthesis of nitric oxide. The mechanisms of action of mesalazine are not yet well understood. It is an anti-inflammatory drug that inhibits factors of the inflammatory cascade (such as cyclooxygenase) and free radicals, and has an intrinsic antioxidant effect. Some recent studies confirm the efficacy of mesalazine in diverticular disease both in relief of symptoms in symptomatic uncomplicated forms and in prevention of recurrence of symptoms and main complications.

Authors+Show Affiliations

Department of Clinical Sciences, University of Parma, 43100 Parma, Italy. francesco.dimario@unipr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16885700

Citation

Di Mario, Francesco, et al. "Use of Mesalazine in Diverticular Disease." Journal of Clinical Gastroenterology, vol. 40 Suppl 3, 2006, pp. S155-9.
Di Mario F, Comparato G, Fanigliulo L, et al. Use of mesalazine in diverticular disease. J Clin Gastroenterol. 2006;40 Suppl 3:S155-9.
Di Mario, F., Comparato, G., Fanigliulo, L., Aragona, G., Cavallaro, L. G., Cavestro, G. M., & Franzé, A. (2006). Use of mesalazine in diverticular disease. Journal of Clinical Gastroenterology, 40 Suppl 3, S155-9.
Di Mario F, et al. Use of Mesalazine in Diverticular Disease. J Clin Gastroenterol. 2006;40 Suppl 3:S155-9. PubMed PMID: 16885700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of mesalazine in diverticular disease. AU - Di Mario,Francesco, AU - Comparato,Giuseppe, AU - Fanigliulo,Libera, AU - Aragona,Giovanni, AU - Cavallaro,Lucas G, AU - Cavestro,Giulia M, AU - Franzé,Angelo, PY - 2006/8/4/pubmed PY - 2006/12/9/medline PY - 2006/8/4/entrez SP - S155 EP - 9 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 40 Suppl 3 N2 - Diverticular disease includes a spectrum of conditions sharing the underlying pathology of acquired diverticula of the colon: symptomatic uncomplicated diverticular disease, recurrent symptomatic uncomplicated diverticular disease, and complicated diverticular disease. Goals of therapy in diverticular disease should be to improve symptoms and to prevent recurrent attacks in symptomatic uncomplicated diverticular disease, and to prevent the complications of disease such as diverticulitis. Inflammation seems to play a key role in all forms of the disease. This is the rationale for the use of anti-inflammatory drugs such as mesalazine. Inflammation in such diseases seems to be generated by a heightened production of proinflammatory cytokines, reduced anti-inflammatory cytokines, and enhanced intramucosal synthesis of nitric oxide. The mechanisms of action of mesalazine are not yet well understood. It is an anti-inflammatory drug that inhibits factors of the inflammatory cascade (such as cyclooxygenase) and free radicals, and has an intrinsic antioxidant effect. Some recent studies confirm the efficacy of mesalazine in diverticular disease both in relief of symptoms in symptomatic uncomplicated forms and in prevention of recurrence of symptoms and main complications. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/16885700/Use_of_mesalazine_in_diverticular_disease_ L2 - https://doi.org/10.1097/01.mcg.0000225509.98041.4b DB - PRIME DP - Unbound Medicine ER -