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Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester.
Eur J Clin Nutr. 2007 Jan; 61(1):83-90.EJ

Abstract

OBJECTIVE

To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy.

DESIGN

A cross-sectional, observational study.

SUBJECTS

Pregnant women in the first trimester, at 7-15 weeks gestation (n=70), who were not consuming any folate supplements or folate fortified foods.

METHODS

Three-day dietary records were obtained from each subject to assess dietary folate intake. Blood samples were collected for measurement of biomarkers. Biomarkers and nutrient intake were analyzed in two groups defined by their serum folate concentrations: the low folate group (serum folate < 9 ng/ml) and the high folate group (serum folate > or = 9 ng/ml).

RESULT

Mean serum and RBC folate concentrations in all subjects were 10.3 and 519 ng/ml, respectively. These levels were remarkably higher than the reported values from many other countries despite our subjects receiving no folic acids supplements. However, mean folate intake by our subjects from natural foods was 289 microg/day, which is thought to be low according to the Japanese dietary recommendation specified for pregnant women. The intake of spinach and fruits was significantly greater in the high folate group than in the low folate group.

CONCLUSION

Folate intake was thought to be adequate to maintain a desirable level of serum folate concentration in Japanese pregnant women in the first trimester, although the intake of folate from natural food was not high enough to meet the recommended daily intake.

Authors+Show Affiliations

Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan. himawari@nih.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16885932

Citation

Mito, N, et al. "Folate Intakes and Folate Biomarker Profiles of Pregnant Japanese Women in the First Trimester." European Journal of Clinical Nutrition, vol. 61, no. 1, 2007, pp. 83-90.
Mito N, Takimoto H, Umegaki K, et al. Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. Eur J Clin Nutr. 2007;61(1):83-90.
Mito, N., Takimoto, H., Umegaki, K., Ishiwaki, A., Kusama, K., Fukuoka, H., Ohta, S., Abe, S., Yamawaki, M., Ishida, H., & Yoshiike, N. (2007). Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. European Journal of Clinical Nutrition, 61(1), 83-90.
Mito N, et al. Folate Intakes and Folate Biomarker Profiles of Pregnant Japanese Women in the First Trimester. Eur J Clin Nutr. 2007;61(1):83-90. PubMed PMID: 16885932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. AU - Mito,N, AU - Takimoto,H, AU - Umegaki,K, AU - Ishiwaki,A, AU - Kusama,K, AU - Fukuoka,H, AU - Ohta,S, AU - Abe,S, AU - Yamawaki,M, AU - Ishida,H, AU - Yoshiike,N, Y1 - 2006/08/02/ PY - 2006/8/4/pubmed PY - 2007/2/28/medline PY - 2006/8/4/entrez SP - 83 EP - 90 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 1 N2 - OBJECTIVE: To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy. DESIGN: A cross-sectional, observational study. SUBJECTS: Pregnant women in the first trimester, at 7-15 weeks gestation (n=70), who were not consuming any folate supplements or folate fortified foods. METHODS: Three-day dietary records were obtained from each subject to assess dietary folate intake. Blood samples were collected for measurement of biomarkers. Biomarkers and nutrient intake were analyzed in two groups defined by their serum folate concentrations: the low folate group (serum folate < 9 ng/ml) and the high folate group (serum folate > or = 9 ng/ml). RESULT: Mean serum and RBC folate concentrations in all subjects were 10.3 and 519 ng/ml, respectively. These levels were remarkably higher than the reported values from many other countries despite our subjects receiving no folic acids supplements. However, mean folate intake by our subjects from natural foods was 289 microg/day, which is thought to be low according to the Japanese dietary recommendation specified for pregnant women. The intake of spinach and fruits was significantly greater in the high folate group than in the low folate group. CONCLUSION: Folate intake was thought to be adequate to maintain a desirable level of serum folate concentration in Japanese pregnant women in the first trimester, although the intake of folate from natural food was not high enough to meet the recommended daily intake. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16885932/Folate_intakes_and_folate_biomarker_profiles_of_pregnant_Japanese_women_in_the_first_trimester_ L2 - https://doi.org/10.1038/sj.ejcn.1602497 DB - PRIME DP - Unbound Medicine ER -