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Nutritional determinants of plasma total homocysteine distribution in the Canary Islands.
Eur J Clin Nutr. 2007 Jan; 61(1):111-8.EJ

Abstract

OBJECTIVE

We sought to define plasma homocysteine reference values in healthy individuals in the Canary Islands and to determine its relations to folate and vitamin B12 intakes and concentrations.

DESIGN

Cross-sectional study.

SETTING

Population-based representative sample of 557 participants, aged 18-65 years, from the Canary Islands Nutrition Survey (ENCA).

SUBJECTS

All participants completed two 24-h dietary recalls and a general questionnaire collecting socio-demographic and health-related lifestyle information.

INTERVENTIONS

Plasma homocysteine and serum vitamin B12 levels were measured by immunoassay, whereas folate levels through an automated ionic capturing method.

RESULTS

Median plasma homocysteine was 11.9 micromol/l, higher in men (13.1 micromol/l) than in women (10.9 micromol/l) (P<0.001) and positively associated with age in both sexes (P<0.001). The prevalence of hyperhomocysteinaemia (> or = 15 micromol/l), 21.4%, was also greater in men (32.2%) than in women (13.4%). There were significant negative correlations between plasma homocysteine and serum (r=-0.32, P<0.001) and erythrocyte (r=-0.26, P<0.001) folate, as well as serum vitamin B12 (r=-0.28, P<0.001) concentrations. When divided in quartiles of vitamin intakes or concentrations, men with the lowest vitamin B12 and folate serum values had significantly higher plasma homocysteine concentrations than those in the other three quartiles. In women, hyperhomocysteinaemia was higher in the lowest quartiles of folate intake and serum and erythrocyte folate concentrations.

CONCLUSIONS

These data provide further evidence that hyperhomocysteinaemia is a sensitive marker of inadequate folate and vitamin B12 status, allowing for the identification of those with greatest need for nutritional interventions.

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Authors+Show Affiliations

Henríquez P
Department of Clinical Sciences, Health Sciences Faculty, University of Las Palmas of Gran Canaria, Canary Islands, Spain. phenriquez@denf.ulpgc.es
Doreste J
No affiliation info available
Deulofeu R
No affiliation info available
Fiuza MD
No affiliation info available
Serra-Majem L
No affiliation info available

MeSH

AdolescentAdultAge FactorsAgedBiomarkersCross-Sectional StudiesDietErythrocytesFemaleFolic AcidHomocysteineHumansHyperhomocysteinemiaLife StyleMaleMental RecallMiddle AgedNutrition SurveysPrevalenceReference ValuesSex FactorsSpainSurveys and QuestionnairesVitamin B 12

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16885934

Citation

Henríquez, P, et al. "Nutritional Determinants of Plasma Total Homocysteine Distribution in the Canary Islands." European Journal of Clinical Nutrition, vol. 61, no. 1, 2007, pp. 111-8.
Henríquez P, Doreste J, Deulofeu R, et al. Nutritional determinants of plasma total homocysteine distribution in the Canary Islands. Eur J Clin Nutr. 2007;61(1):111-8.
Henríquez, P., Doreste, J., Deulofeu, R., Fiuza, M. D., & Serra-Majem, L. (2007). Nutritional determinants of plasma total homocysteine distribution in the Canary Islands. European Journal of Clinical Nutrition, 61(1), 111-8.
Henríquez P, et al. Nutritional Determinants of Plasma Total Homocysteine Distribution in the Canary Islands. Eur J Clin Nutr. 2007;61(1):111-8. PubMed PMID: 16885934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional determinants of plasma total homocysteine distribution in the Canary Islands. AU - Henríquez,P, AU - Doreste,J, AU - Deulofeu,R, AU - Fiuza,M D, AU - Serra-Majem,L, Y1 - 2006/08/02/ PY - 2006/8/4/pubmed PY - 2007/2/28/medline PY - 2006/8/4/entrez SP - 111 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 1 N2 - OBJECTIVE: We sought to define plasma homocysteine reference values in healthy individuals in the Canary Islands and to determine its relations to folate and vitamin B12 intakes and concentrations. DESIGN: Cross-sectional study. SETTING: Population-based representative sample of 557 participants, aged 18-65 years, from the Canary Islands Nutrition Survey (ENCA). SUBJECTS: All participants completed two 24-h dietary recalls and a general questionnaire collecting socio-demographic and health-related lifestyle information. INTERVENTIONS: Plasma homocysteine and serum vitamin B12 levels were measured by immunoassay, whereas folate levels through an automated ionic capturing method. RESULTS: Median plasma homocysteine was 11.9 micromol/l, higher in men (13.1 micromol/l) than in women (10.9 micromol/l) (P<0.001) and positively associated with age in both sexes (P<0.001). The prevalence of hyperhomocysteinaemia (> or = 15 micromol/l), 21.4%, was also greater in men (32.2%) than in women (13.4%). There were significant negative correlations between plasma homocysteine and serum (r=-0.32, P<0.001) and erythrocyte (r=-0.26, P<0.001) folate, as well as serum vitamin B12 (r=-0.28, P<0.001) concentrations. When divided in quartiles of vitamin intakes or concentrations, men with the lowest vitamin B12 and folate serum values had significantly higher plasma homocysteine concentrations than those in the other three quartiles. In women, hyperhomocysteinaemia was higher in the lowest quartiles of folate intake and serum and erythrocyte folate concentrations. CONCLUSIONS: These data provide further evidence that hyperhomocysteinaemia is a sensitive marker of inadequate folate and vitamin B12 status, allowing for the identification of those with greatest need for nutritional interventions. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16885934/Nutritional_determinants_of_plasma_total_homocysteine_distribution_in_the_Canary_Islands_ L2 - https://doi.org/10.1038/sj.ejcn.1602490 DB - PRIME DP - Unbound Medicine ER -