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Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.
Anticancer Res. 2006 Jul-Aug; 26(4A):2669-81.AR

Abstract

Colorectal cancer is a major health problem worldwide. Epidemiological studies and work on experimental animals strongly suggest a protective effect of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) against colon neoplasia. 1,25(OH)2D3 is a pleiotropic hormone that has multiple actions in the organism. By binding to the widely expressed high affinity vitamin D receptor (VDR) it regulates the transcription rate of many genes. Other non-genomic effects of 1,25(OH)2D3 also appear to modulate the physiology of numerous cell types. Human normal and cancer colon epithelial cells express VDR and the key enzymes involved in 1,25(OH)2D3 synthesis and degradation and are, thus, responsive to the hormone. 1,25(OH)2D3 inhibits proliferation, induces differentiation and sometimes the apoptosis of human colon cancer cells. A great variety of mechanisms and signaling pathways are involved. Since VDR mediates most, if not all, 1,25(OH)2D3 actions, the control of VDR expression is a crucial aspect of 1,25(OH)2D3 biology. Here, the molecular mechanisms underlying the actions of 1,25(OH)2D3 are reviewed and the repression of the VDR gene by the transcription factor SNAIL in human colon cancer cells is discussed. Understanding these mechanisms may provide the basis for the potential use of this hormone and its non-hypercalcemic derivatives in the prevention and treatment of colon cancer.

Authors+Show Affiliations

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, E-28029 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16886677

Citation

González-Sancho, José Manuel, et al. "Effects of 1alpha,25-dihydroxyvitamin D3 in Human Colon Cancer Cells." Anticancer Research, vol. 26, no. 4A, 2006, pp. 2669-81.
González-Sancho JM, Larriba MJ, Ordóñez-Morán P, et al. Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Anticancer Res. 2006;26(4A):2669-81.
González-Sancho, J. M., Larriba, M. J., Ordóñez-Morán, P., Pálmer, H. G., & Muñoz, A. (2006). Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Anticancer Research, 26(4A), 2669-81.
González-Sancho JM, et al. Effects of 1alpha,25-dihydroxyvitamin D3 in Human Colon Cancer Cells. Anticancer Res. 2006 Jul-Aug;26(4A):2669-81. PubMed PMID: 16886677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. AU - González-Sancho,José Manuel, AU - Larriba,María Jesús, AU - Ordóñez-Morán,Paloma, AU - Pálmer,Héctor G, AU - Muñoz,Alberto, PY - 2006/8/5/pubmed PY - 2006/8/23/medline PY - 2006/8/5/entrez SP - 2669 EP - 81 JF - Anticancer research JO - Anticancer Res VL - 26 IS - 4A N2 - Colorectal cancer is a major health problem worldwide. Epidemiological studies and work on experimental animals strongly suggest a protective effect of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) against colon neoplasia. 1,25(OH)2D3 is a pleiotropic hormone that has multiple actions in the organism. By binding to the widely expressed high affinity vitamin D receptor (VDR) it regulates the transcription rate of many genes. Other non-genomic effects of 1,25(OH)2D3 also appear to modulate the physiology of numerous cell types. Human normal and cancer colon epithelial cells express VDR and the key enzymes involved in 1,25(OH)2D3 synthesis and degradation and are, thus, responsive to the hormone. 1,25(OH)2D3 inhibits proliferation, induces differentiation and sometimes the apoptosis of human colon cancer cells. A great variety of mechanisms and signaling pathways are involved. Since VDR mediates most, if not all, 1,25(OH)2D3 actions, the control of VDR expression is a crucial aspect of 1,25(OH)2D3 biology. Here, the molecular mechanisms underlying the actions of 1,25(OH)2D3 are reviewed and the repression of the VDR gene by the transcription factor SNAIL in human colon cancer cells is discussed. Understanding these mechanisms may provide the basis for the potential use of this hormone and its non-hypercalcemic derivatives in the prevention and treatment of colon cancer. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/16886677/Effects_of_1alpha25_dihydroxyvitamin_D3_in_human_colon_cancer_cells_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=16886677 DB - PRIME DP - Unbound Medicine ER -