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The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates.
Anticancer Res 2006 Jul-Aug; 26(4A):2687-99AR

Abstract

BACKGROUND

Solar ultraviolet B (UVB) irradiance and vitamin D are associated with reduced cancer mortality rates. However, the previous ecologic study of UVB and cancer mortality rates in the U.S. (Grant, 2002) did not include other risk factors in the analysis.

MATERIALS AND METHODS

An ecologic study was performed using age-adjusted annual mortality rates for Caucasian Americans for 1950-69 and 1970-94, along with state-averaged values for selected years for alcohol consumption, Hispanic heritage, lung cancer (as a proxy for smoking), poverty, degree of urbanization and UVB in multiple regression analyses.

RESULTS

Models were developed that explained much of the variance in cancer mortality rates, with stronger correlations for the earlier period. Fifteen types of cancer were inversely-associated with UVB. In the earlier period, most of the associations of cancer death rates with alcohol consumption (nine), Hispanic heritage (six), the proxy for smoking (ten), urban residence (seven) and poverty (inverse for eight) agreed well with the literature.

CONCLUSION

These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.

Authors+Show Affiliations

Sunlight, Nutrition and Health Research Center (SUNARC), 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109-2529, USA. wgrant@sunarc.orgNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16886679

Citation

Grant, William B., and Cedric F. Garland. "The Association of Solar Ultraviolet B (UVB) With Reducing Risk of Cancer: Multifactorial Ecologic Analysis of Geographic Variation in Age-adjusted Cancer Mortality Rates." Anticancer Research, vol. 26, no. 4A, 2006, pp. 2687-99.
Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006;26(4A):2687-99.
Grant, W. B., & Garland, C. F. (2006). The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Research, 26(4A), pp. 2687-99.
Grant WB, Garland CF. The Association of Solar Ultraviolet B (UVB) With Reducing Risk of Cancer: Multifactorial Ecologic Analysis of Geographic Variation in Age-adjusted Cancer Mortality Rates. Anticancer Res. 2006;26(4A):2687-99. PubMed PMID: 16886679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. AU - Grant,William B, AU - Garland,Cedric F, PY - 2006/8/5/pubmed PY - 2006/8/23/medline PY - 2006/8/5/entrez SP - 2687 EP - 99 JF - Anticancer research JO - Anticancer Res. VL - 26 IS - 4A N2 - BACKGROUND: Solar ultraviolet B (UVB) irradiance and vitamin D are associated with reduced cancer mortality rates. However, the previous ecologic study of UVB and cancer mortality rates in the U.S. (Grant, 2002) did not include other risk factors in the analysis. MATERIALS AND METHODS: An ecologic study was performed using age-adjusted annual mortality rates for Caucasian Americans for 1950-69 and 1970-94, along with state-averaged values for selected years for alcohol consumption, Hispanic heritage, lung cancer (as a proxy for smoking), poverty, degree of urbanization and UVB in multiple regression analyses. RESULTS: Models were developed that explained much of the variance in cancer mortality rates, with stronger correlations for the earlier period. Fifteen types of cancer were inversely-associated with UVB. In the earlier period, most of the associations of cancer death rates with alcohol consumption (nine), Hispanic heritage (six), the proxy for smoking (ten), urban residence (seven) and poverty (inverse for eight) agreed well with the literature. CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/16886679/The_association_of_solar_ultraviolet_B__UVB__with_reducing_risk_of_cancer:_multifactorial_ecologic_analysis_of_geographic_variation_in_age_adjusted_cancer_mortality_rates_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=16886679 DB - PRIME DP - Unbound Medicine ER -